$45.00
Your discount applies with code HOLISTICLOVE.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
A broad-spectrum digestive enzyme blend -- proteases, amylase, and lipase -- taken with food. These are the same categories of enzyme the pancreas releases to break protein, starch, and fat into absorbable pieces, so the blend lends a hand to the digestion already underway during a meal.
Why the evidence supports it
Supplemental digestive enzymes have a reasonable evidence base for easing the sense of heaviness and bloating after meals, and the mechanism is direct: proteases, amylase, and lipase break the meal into the smaller pieces the gut can actually take up. That ties straight to the cell's Exchange function -- better-broken-down food means the nutrients cells need can be absorbed. The framing stays honest: this supports normal digestion and comfort, it is not a treatment for a diagnosed digestive condition.
What it supports
- Supports comfortable digestion after meals
- Provides protein-, starch-, and fat-digesting enzymes
- Supports normal nutrient absorption
- A sensible option for post-meal heaviness or bloating
Which function it supports
Ties to the cell's Exchange function -- better-digested food means the nutrients cells need can actually be taken in.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (1 profiled ingredients). Structure and function only -- not a treatment claim.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- A Randomized, Placebo-controlled Trial of Digestive Enzymes in Children with Autism Spectrum Disorders
Clinical Psychopharmacology and Neuroscience · 2015
In a small randomized placebo-controlled trial, a digestive-enzyme supplement was associated with improvements in some gastrointestinal and behavioral measures; single small RCT, structure/function support for digestion.
- A Randomized, Placebo-controlled Trial of Digestive Enzymes in Children with Autism Spectrum Disorders.
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2015
In a 3 month trial of 101 children with autism spectrum disorder, those given digestive enzymes showed more improvement in behavior, emotional response and gut symptoms than those given placebo.
- Detergent protease exposure and respiratory disease: case-referent analysis of a retrospective cohort
Occupational and environmental medicine · 2009
Detergent protease exposure showed clear monotonic dose-response relationship with occupational respiratory disease in European detergent factory workers.
- The role of protease activation of inflammation in allergic respiratory diseases
The Journal of allergy and clinical immunology · 2004
A review explains that proteases from mites and moulds growing in damp, water-damaged buildings can activate airway receptors that trigger inflammation, potentially contributing to rhinitis, asthma and nasal polyps.
- Protease-activated receptor 1 as an endogenous model of peptidergic Gαq-Gα12-biased G protein signaling
2026
In primary human platelets and cell assays, thrombin activated a receptor's Gaq and Ga12 signaling together, while a related protease triggered only Ga12 signaling, showing distinct outcomes depending on which protein cleaves it.
- Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach
2021
In a computer modelling study, andrographolide from Andrographis paniculata docked into the SARS-CoV-2 main protease binding site and passed drug-likeness and absorption predictions; nothing was tested in cells or people.
Do workplace-based mindfulness meditation programs improve physiological indices of stress? A systematic review and meta-analysisEstablishedMeta-analysis2018
A systematic review and meta-analysis of nine workplace studies found mindfulness-based programs reduced diurnal cortisol slopes and salivary alpha-amylase, and improved heart-rate-variability coherence, but did not change blood pressure.
Heckenberg RA; Eddy P; Kent S; Wright BJ -- Journal of psychosomatic research
Effectiveness of Mindfulness-Based Stress Reduction on Salivary Cortisol and α-amylase Level, Anxiety and Depression in Students: A Randomized and Parallel-Group Clinical TrialEstablishedRandomized controlled trial2025
In 30 students randomized to mindfulness-based stress reduction or control, the training improved general health and salivary alpha-amylase measures more than control, but did not significantly change students' cortisol levels.
Hassanvandi S; Mohammadzadegan R; Saadat SH; Hatef B; Shahyad S -- Applied psychophysiology and biofeedback
The Effects of Hand Massage on Stress and Agitation Among People with Dementia in a Hospital Setting: A Pilot StudyEmergingRandomized controlled trial2018
In 40 agitated hospitalised patients with dementia, seven hand massages over three weeks did not significantly change agitation scores; salivary stress markers rose in week one, then fell, significantly so for alpha-amylase at week two.
Corinne Schaub; Armin von Gunten; Diane Morin; Pascal Wild; Patrick Gomez; Julius Popp -- Applied Psychophysiology and Biofeedback
The short-term impact of music interventions on stress: Results of a multinational cluster-randomized trial using salivary cortisol and alpha-amylase assessments in care home residents with dementia.Randomized controlled trial2025
A multinational cluster-randomized trial found music therapy sessions produced significant pre-to-post reductions in salivary cortisol, alpha-amylase, and subjective stress in dementia care home residents.
Rasing NL; Janus SIM; Vink AC; Frischen UAS; Neuser J; Wake JD; Skoluda N; Sveinsdottir V; Geretsegger M; Langeland E; Kreutz G; Gold C; Nater UM; Zuidema SU -- Psychoneuroendocrinology
Effects of Mulberry Leaf and Corn Silk Extracts Against Alpha-Amylase and Alpha-Glucosidase In Vitro and on Postprandial Glucose in Prediabetic Individuals: A Randomized Crossover TrialEstablishedRandomized controlled trial2025
Mulberry leaf and corn silk extracts inhibited digestive enzymes in vitro, but in a small crossover trial of prediabetic adults the glucose-lowering effect appeared only in an overweight subgroup, not across all participants.
Sun Y et al. -- Nutrients
SimSAARlabim study - The role magic tricks play in reducing pain and stress in childrenEstablishedRandomized controlled trial2024
In 50 children aged 6-11 receiving routine vaccination, adding a magician's magic tricks did not significantly change heart rate, pain scores, or salivary cortisol, IgA and amylase stress markers compared to no tricks.
Teichfischer J; Weber R; Kaiser E; Poryo M; Weise JJ; Nisius A; Meyer S -- Vaccine
Neuromodulatory Interventions in Experimental Acute Pancreatitis: A Systematic Review of Rodent StudiesEmergingExpert review2026
In a systematic review of nine rodent studies, serotonergic blockers lowered serum amylase and lipase by 37 to 65 percent, but all interventions were given before or just after induction and bias risk was mostly unclear.
Maxim Rantsev; Alexey Sarapultsev; Valeriy Chereshnev
The biological functions of monoacylglycerol lipase (MAGL) in cancerEmergingExpert review2026
In a review, MAGL hydrolyzes 2-arachidonoylglycerol to produce arachidonic acid and free fatty acids that drive pro-inflammatory lipid mediators supporting tumor progression.
Faris Almutairi
Recent advances in neurodegenerative diseases therapeutics: The inhibition of monoacylglycerol lipase strategyEmergingExpert review2026
In a review, MAGL inhibition reduced neuroinflammation and neurodegeneration in preclinical models of Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis.
Delia Maciel Mendoza-Camacho; Hugo Alejandro Espinoza-Gutiérrez; Juan Manuel Viveros-Paredes; Mario Eduardo Flores-Soto; Aldo Rafael Tejeda-Martínez
The Role of Monoacylglycerol Lipase (MAGL) in Substance Use: A Systematic Review of Preclinical StudiesEmergingExpert review2026
In a systematic review of preclinical studies, MAGL inhibition consistently reduced withdrawal across cannabis, opioid, and nicotine models but showed variable effects on reward.
Bertina Jebanesan; Khadija Brouillette; Caleb J Browne; Isabelle Boileau; Laura M Best
Physical activity, cathepsin B, and cognitive healthEmergingExpert review2025
A review found physical activity raises plasma cathepsin B, a muscle-released protease linked to hippocampal neurogenesis and synaptic plasticity, but evidence for its role in human cognitive benefits is mixed.
Yu Q; Zhang Z; Herold F; Ludyga S; Kuang J; Chen Y; Liu Z; Erickson KI; Goodpaster BH; Cheval B; Pindus DM; Kramer AF; Hillman CH; Liu-Ambrose T; Kelley KW; Moon HY; Chen A; Zou L -- Trends in molecular medicine
Music-based interventions at workplaces: a scoping reviewEmergingExpert review2025
A scoping review found 25 of 30 workplace studies reported music-based interventions improved mood, reduced anxiety and stress, and lowered physiological markers like heart rate and salivary amylase, though 5 studies found no effect.
Israel Paul Nyarubeli; Bente E Moen; Viggo Krüger; Brynjulf Stige
Therapeutic Potentials of Medicinal Leech in Chinese MedicineEmergingExpert review2024
In a review of Chinese medicine practice, leech-derived proteins are grouped into direct anticoagulants such as hirudin, heparin and histamine, and protease inhibitors like decorsin and hementin, with hirudin the strongest thrombin inhibitor described.
Wu S; Zhou Y; Wang Y; Zhang Z -- The American journal of Chinese medicine
An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)EmergingExpert review2021
In a review of 2018-present patents, MAGL inhibitor development accelerated, with reversible inhibitors remaining an unmet pharmaceutical need despite growing structural diversity.
Bononi G; Poli G; Rizzolio F; Tuccinardi T; Macchia M; Minutolo F; Granchi C -- Expert opinion on therapeutic patents
Possible Beneficial Actions of Caffeine in SARS-CoV-2EmergingExpert review2021
A review discussed caffeine inhibiting 3-chymotrypsin-like protease activity as a possible mechanism against SARS-CoV-2, with in vitro and in vivo validation still required.
Romero-Martínez BS; Montaño LM; Solís-Chagoyán H; Sommer B; Ramírez-Salinas GL; Pérez-Figueroa GE; Flores-Soto E -- International journal of molecular sciences
Endocannabinoid Metabolism and Traumatic Brain InjuryEmergingExpert review2021
In a review, monoacylglycerol lipase inhibition enhances 2-AG signaling, reducing neuroinflammation and improving cognitive outcomes after traumatic brain injury.
Zhu D; Gao F; Chen C -- Cells
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase InhibitorsEmergingExpert review2021
A 2021 review evaluates FAAH and MAGL inhibitors that have reached human clinical trials for modulating brain endocannabinoid signaling, discussing safety caveats versus direct CB1 agonism by THC and future research directions.
van Egmond N; Straub VM; van der Stelt M -- Annual review of pharmacology and toxicology
Collagen in Wound HealingEmergingExpert review2021
A review of collagen's role across the inflammatory, proliferative and remodelling phases of skin repair, and of collagen-based dressings used as adjuncts; wounds stall when protease activity and inflammation stay high. Molecular review, not a modality study.
Shomita S. Mathew‐Steiner; Sashwati Roy; Chandan K. Sen -- Bioengineering
Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative ReviewEmergingExpert review2021
A review found MAGL and DAGL inhibition lowered body weight in animal models and FAAH inhibition tended to increase it, while human genetic association studies of these enzymes mostly found no link to obesity.
Justin Matheson; Xin Ming Matthew Zhou; Zoe Bourgault; Bernard Le Foll -- Pharmaceuticals
Stress System Activation in Children and Adolescents With Autism Spectrum DisorderEmergingExpert review2021
In a review of children and adolescents with autism spectrum disorder, atypical HPA axis and autonomic nervous system function was observed, including altered cortisol and alpha-amylase circadian rhythms.
Makris G; Agorastos A; Chrousos GP; Pervanidou P -- Frontiers in neuroscience
Dopamine D1 receptor signaling and endocannabinoid cooperate to fuel striatal plasticity: An Editorial Highlight for "Cyclic AMP-dependent protein kinase and D1 dopamine receptors regulate diacylglycerol lipase-α and synaptic 2-arachidonoyl glycerol signaling" on page 334EmergingExpert review2020
In a commentary, dopamine D1 receptor activation increases 2-arachidonoylglycerol synthesis via cAMP-dependent protein kinase phosphorylation of diacylglycerol lipase-alpha.
Socodato R -- Journal of neurochemistry
Monoacylglycerol lipase (MAGL) as a promising therapeutic targetEmergingExpert review2018
In a review, MAGL functions as a metabolic hub regulating not only 2-arachidonoylglycerol levels but also other monoacylglycerols and pro-inflammatory lipid mediators.
Gil-Ordóñez A; Martín-Fontecha M; Ortega-Gutiérrez S; López-Rodríguez ML -- Biochemical pharmacology
Cosolvent-induced spontaneous refolding of lipaseEmerging2026
Incubating soluble Burkholderia lipase with cosolvents raised activity to 1003 U/mL in 25 percent glycerol, 754 in 15 percent DMSO and 501 in 4 M TMAO, with simulations showing glycerol displaced hydration shell water.
Cheng Cheng; Yongqin Su; Lupeng Cui; Yumeng Qiu; Jialing Wang; Tianyue Jiang; Bingfang He
Isolation and antioxidant activity of peptides from Chinese hairy tofu.2024
Pancreatin-hydrolyzed hairy tofu peptides showed the highest antioxidant activity among seven proteases tested, with four purified peptides significantly reducing malondialdehyde content in H2O2-stressed 293T cells at concentrations below 50 micrograms per mL.
Wu LP; Wu YX; Ke XT; Wang P; Zhang S; Zhu YT; Lu Y; Shu YJ; Jiang SY; Li CJ; Hu XQ -- Journal of peptide science : an official publication of the European Peptide Society
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Digest-It-All is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Digest-It-All pairs with for each. Nothing works in isolation; these share the same systems.
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take with the first few bites of a meal, especially larger or richer meals, with water. Follow the brand's serving size.
Use code HOLISTICLOVE at checkout.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get Digest-It-AllThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Digest-It-All is a broad-spectrum digestive enzyme blend -- proteases, amylase, and lipase -- taken with food to help your body break meals down. It is aimed at comfortable digestion and getting more out of what you eat. It fits people who feel heavy or bloated after meals.
FAQ
What does Digest-It-All support?
It supports comfortable digestion after meals, provides protein-, starch-, and fat-digesting enzymes, supports normal nutrient absorption, and is a sensible option for post-meal heaviness or bloating.
How do I take it?
Take with the first few bites of a meal, especially larger or richer meals, with water. Follow the brand's serving size.
What makes it different?
Digestive enzymes are a reasonable, low-risk thing to try. Taken with the meal, it lends a hand to the breakdown your body already does. It supports normal digestion and comfort, not a diagnosed condition.