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$144.00 save $29.00 -- applied automatically through this link
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What it is
Only about 1 in 8 adults is metabolically healthy -- and that is exactly the problem ageLOC Meta is built for. It is a concentrated anthocyanin blend standardized to 215 mg per serving, drawn from black rice, black currant, and bilberry and built around the two pigments the research pointed to, cyanidin and delphinidin -- the deep purple-red compounds studied for metabolic and antioxidant support. Taken as four softgels daily, it is aimed squarely at the metabolic chemistry of how your body handles a meal.
Why the evidence supports it
Meta is named for metabolic chemistry, and that is the honest center of its evidence -- not a generic antioxidant story. The finished blend has its own signal: subjects who took it before a rich, high-fat meal showed a more favorable metabolic and inflammatory response than placebo. Behind that, its cyanidin and delphinidin -- chosen through LifeGen's gene-expression screening for their metabolic gene modulation, not antioxidant chemistry alone -- reach a striking spread of metabolic systems, and the human evidence is strongest right where the name points: the liver (anthocyanin trials lower ALT and liver-injury markers in people with fatty liver), the gut (they shift the microbiome toward more short-chain-fat production and help tighten the gut barrier), plus fat oxidation and healthy insulin and glucose handling -- with emerging work on the pancreas, on muscle glucose uptake, and on neuroprotection. Its anthocyanins do also switch on NRF2, which is one of these levers and where the everyday antioxidant-and-clearing piece comes in -- but the headline is metabolic breadth, honestly graded: liver and microbiome rest on human trials, while the pancreas and muscle links are still emerging. Kept honest, it supports the cell's Transform function -- how the body handles and clears the energy of a meal -- not weight loss or a blood-sugar treatment.
What it supports
- Supports the body's own antioxidant defenses
- Supports a healthy inflammation response around a meal
- Provides a concentrated spectrum of dietary anthocyanins
- Complements a balanced diet and everyday metabolic habits
Which function it supports
Ties to the cell's Transform function -- supporting metabolic chemistry across the liver, gut and microbiome, fat oxidation, and how the body handles and clears the energy of a meal.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (4 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision 2022-09-30Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 4 softgels | Amount | % DV |
|---|---|---|
| Calories | 15 | |
| Total Fat | 1 g | 1.5% |
| Total Carbohydrates | 1 g | 0% |
| ageLOC Meta Blendstandardized to 215 mg total anthocyanins; Black Rice (Oryza sativa L.) Extract, Black Currant (Ribes nigrum) Fruit Extract, Bilberry (Vaccinium myrtillus) Fruit Extract | 897.2 mg | † |
- Servings per container:
- 30
- Other ingredients:
- Olive Oil, Gelatin, Glycerin, Sunflower Lecithin, Beeswax.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Physicochemical and functional modifications induced by purple corn flour (Zea mays L.) and their sensory implications for loaf breads.
Frontiers in nutrition · 2026
Substituting 30 percent of wheat flour with purple corn flour increased bread protein, fiber, and phenolic content including gallic and chlorogenic acids, though it also increased hardness and reduced consumer sensory acceptance versus 15 percent substitution.
- Storage stability of an antioxidant tea prepared from purple corn (Zea mays L.) cob and stevia (Stevia rebaudiana Bert.) and its effects on biomarkers of oxidative stress in healthy humans.
Food research international (Ottawa, Ont.) · 2025
A purple corn and stevia antioxidant tea retained most of its polyphenol content during storage, and in healthy adults its consumption lowered two oxidative stress biomarkers over several weeks without shifting an overall oxidative stress score.
- Microencapsulation of highly concentrated polyphenolic compounds from purple corn pericarp by spray-drying with various biomacromolecules.
International journal of biological macromolecules · 2024
Spray-drying purple corn polyphenols with carrier materials like maltodextrin or gum arabic preserved their antioxidant content, offering a stable delivery form for supplements.
- Anthocyanins in metabolites of purple corn.
Frontiers in plant science · 2023
A review describes the biosynthesis pathway and gene regulation mechanisms controlling anthocyanin accumulation in purple corn, along with how environmental factors influence anthocyanin stability during crop growth.
- Linking Anthocyanin Diversity, Hue, And Genetics In Purple Corn
2020
Using a genetically diverse purple corn population, researchers mapped major QTL controlling anthocyanin pigment composition near known loci Pr1 and Aat1, identifying targets for breeding more stable, vividly colored natural food colorants.
- Gwas and Genomic Selection For Increased Anthocyanin Content in Purple Corn
2020
A GWAS of the same purple corn landrace identified a highly significant locus near Aat1 governing anthocyanin acylation, and genomic prediction models achieved 71% accuracy for selecting higher total anthocyanin content in breeding programs.
The effect of dietary anthocyanins on biochemical, physiological, and subjective exercise recovery: a systematic review and meta-analysisEstablishedMeta-analysis2023
A systematic review and meta-analysis found dietary anthocyanins improved biochemical, physiological and subjective markers of exercise recovery.
Kimble R; Jones K; Howatson G -- Critical reviews in food science and nutrition
Anthocyanins as Adjuvant Treatment for Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-AnalysisEmergingMeta-analysis2024
A systematic review and meta-analysis of RCTs reported anthocyanin supplementation improved liver transaminases and lipid measures in patients with fatty liver.
Khan NN; Zurayyir EJ; Almuslem MY; Alshamrani R; Alamri RA; Sulaimani GHT; Sulimani MHT; Albalawi MSF; Alzehair Alqahani RM; Alanazi EM; Aljawi HH; Alsuliman JA -- Cureus
Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysisEstablishedMeta-analysis2023
A systematic review and meta-analysis reported that anthocyanin intake was associated with a lower Firmicutes-to-Bacteroidetes ratio and higher short-chain fatty acids, chiefly acetic acid, largely across rodent gut-health datasets.
Kapoor P; Tiwari A; Sharma S; Tiwari V; Sheoran B; Ali U; Garg M -- Scientific reports
Efficacy and Safety of Anthocyanin-Rich Extract in Patients with Ulcerative Colitis: A Randomized Controlled TrialEstablishedRandomized controlled trial2024
In a randomized placebo-controlled trial in ulcerative colitis patients that ended early and underpowered, bilberry anthocyanin extract did not beat placebo on clinical response but was associated with a significant drop in fecal calprotectin.
Biedermann L; Doulberis M; Schreiner P; Nielsen OH; The FO; Brand S; Burk S; Hruz P; Juillerat P; Krieger-Grübel C; Leu K; Leventhal GE; Misselwitz B; Scharl S; Schoepfer A; Seibold F; Herfarth H; Rogler G -- Nutrients
Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trialEmergingRandomized controlled trial2026
In a 28-day randomized placebo-controlled trial (n=98), a composite polyphenol supplement lowered fecal microplastic concentration and altered immune markers (not anthocyanin-specific).
Zhao L; Zheng J; Shen Y; Xu X; Liu X; Yu J; Li J; Yang B; Chen L; Wang F; Liu S; Peng X; Du J; Dong R -- Nature communications
Effects of a 24-week intervention with freeze-dried blueberries on brain health in older adults: A randomized double-blind, placebo-controlled trialEmergingRandomized controlled trial2026
In a 24-week RCT in cognitively healthy older adults, freeze-dried blueberries were tested for effects on serum neuronal biomarkers (p-tau181, neurofilament light) and cognition.
Guardino ET; Gabriel O; Mukamal KJ; Djousse L -- Clinical nutrition ESPEN
Aronia melanocarpa extract supplementation affects brain vascular function and cognitive performance: A randomized, double-blind, placebo-controlled, cross-over study in older adults with overweight or obesityEmergingRandomized controlled trial2026
In a randomized crossover trial in older adults at cognitive risk, 40 mg/day anthocyanins from Aronia extract for 6 weeks were tested on cerebral blood flow and cognitive performance.
Ahles S; Plat J; Nijssen KM; Joris PJ -- Clinical nutrition (Edinburgh, Scotland)
The effect of anthocyanins through diet and supplementation on cognitive function in older adults: a multi-centre randomised controlled clinical trialEmergingRandomized controlled trial2026
In a multicentre 24-week RCT in adults aged 60-85 with memory complaints, anthocyanins from diet or supplementation were tested for effects on cognitive performance.
do Rosario V; Chan K; Lorzadeh E; Brodaty H; Anstey KJ; Kent K; Roodenrys S; Bliokas V; Phillipson L; Francois ME; Batterham MJ; Cyriac T; Weston-Green K; Jiang X; George J; Potter J; Charlton KE -- Food & function
Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trialEmergingRandomized controlled trial2024
In a randomized crossover trial in overweight, hypertriglyceridemic adults, 1.5 g/day anthocyanin-rich camu-camu for 12 weeks reduced liver fat versus placebo.
Agrinier AL; Morissette A; Daoust L; Gignac T; Marois J; Varin TV; Pilon G; Larose É; Gagnon C; Desjardins Y; Anhê FF; Carreau AM; Vohl MC; Marette A -- Cell reports. Medicine
Blackcurrants shape gut microbiota profile and reduce risk of postmenopausal osteoporosis via the gut-bone axis: Evidence from a pilot randomized controlled trialEmergingRandomized controlled trial2024
In a pilot randomized trial in 40 peri- and postmenopausal women, blackcurrant supplementation was associated with dose-dependent shifts in gut microbiota, including increased Ruminococcus, alongside reduced bone loss.
Nosal BM; Thornton SN; Darooghegi Mofrad M; Sakaki JR; Mahoney KJ; Macdonald Z; Daddi L; Tran TDB; Weinstock G; Zhou Y; Lee EC; Chun OK -- The Journal of nutritional biochemistry
Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trialEmergingRandomized controlled trial2023
In a randomized trial in untrained adults, 18 days of blueberry supplementation raised post-exercise anti-inflammatory oxylipins after eccentric exercise.
Nieman DC; Sakaguchi CA; Omar AM; Davis KL; Shaffner CE; Strauch RC; Lila MA; Zhang Q -- Scientific reports
Cyanidin-3-O-glucoside as a Nutrigenomic Factor in Type 2 Diabetes and Its Prominent Impact on HealthEmergingExpert review2023
This review describes cyanidin-3-O-glucoside as a nutrigenomic anthocyanin that influences gene expression tied to inflammation and glucose metabolism in cell and animal studies, framing it as a dietary modulator of metabolic gene pathways.
Bartel I; Koszarska M; Strzałkowska N; Tzvetkov NT; Wang D; Horbańczuk JO; Wierzbicka A; Atanasov AG; Jóźwik A -- International journal of molecular sciences
Anthocyanins from blueberry and blackberry ameliorate metabolic syndrome by Prevotella histicola and acetic acidEmergingPrimary research (design unspecified)2025
In high-fat-diet mice, blueberry and blackberry anthocyanins were associated with a remodeled gut microbiota and higher acetic acid, and fecal-transplant experiments suggested these microbial changes helped mediate the metabolic benefit.
Du L; Ding X; Zhang W; Huang L; Lü H; Jian T; Li J; Gai Y; Meng X; Niu G; Chen J; Li W -- NPJ science of food
Effects of protocatechuic acid on antioxidant capacity, mitochondrial biogenesis and skeletal muscle fiber transformationEmerging2023
The anthocyanin metabolite protocatechuic acid supported skeletal-muscle mitochondrial biogenesis and a shift toward oxidative (type I) muscle fibers.
Yang L; Chen X; Chen D; Yu B; He J; Luo Y; Zheng P; Chen H; Yan H; Huang Z -- The Journal of nutritional biochemistry
Bilberry (Vaccinium myrtillus L.) extract alleviates gestational diabetes mellitus by coordinating TGR5/FXR signaling via a gut microbiota-bile acid axisEmergingAnimal study2026
In an animal model of gestational diabetes, bilberry extract acted through a gut microbiota-bile acid-TGR5/FXR-GLP-1 axis to support the body's own GLP-1 response.
Jiang S; Meng Q; Jiang C; Lv Y; Liu L; Xie R; Ya F; Gao Q -- Food & function
Dietary anthocyanins alleviate age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota-bile acid-hepatic FXR signalingEmergingAnimal study2026
In 18-month-old mice, dietary cyanidin-3-O-glucoside reduced liver fat accumulation and, by transcriptomic analysis, shifted hepatic gene expression through bile-acid FXR signaling, an animal-level nutrigenomic effect on age-related fatty liver.
Chen S; Wan C; Yu C; Shen T; Zhang H; Xiao J; You Y; Shen X; Li J; Ling W; Huang R; Xue H; Chen X -- Hepatology (Baltimore, Md.)
Delphinidin attenuates cognitive deficits and pathology of Alzheimer's disease by preventing microglial senescence via AMPK/SIRT1 pathwayEmergingAnimal study2025
In an Alzheimer's disease mouse model, delphinidin reduced amyloid-beta-associated microglial senescence and neuroinflammation via the AMPK/SIRT1 pathway.
Liu Y; Hong T; Lv M; Guo X; Zhang P; Yan A; Wei W -- Alzheimer's research & therapy
Chokeberry reduces inflammation in human preadipocytesEmergingPreclinical study2024
In human primary preadipocytes, chokeberry anthocyanin extract lowered palmitate- and LPS-induced IL-6 gene expression and altered its epigenetic marks, showing anthocyanins can down-modulate an inflammatory gene in human fat-cell precursors.
Brunelle DC; Larson KJ; Bundy A; Roemmich JN; Warne D; Redvers N -- Journal of functional foods
Black rice bran extract exerts hepatoprotection via attenuating inflammation and apoptosis in obese-insulin-resistant ratsEmergingAnimal study2024
In obese, insulin-resistant rats, black rice bran extract (a cyanidin-3-glucoside-rich source) reduced hepatic inflammation and apoptosis, protecting the liver.
Laorodphun P; Panya A; Swe MT; Arjinajarn P -- Heliyon
Cyanidin-3-O-Glucoside Alleviates Alcoholic Liver Injury via Modulating Gut Microbiota and Metabolites in MiceEmergingAnimal study2024
In mice, cyanidin-3-O-glucoside (the dominant anthocyanin in black rice) reduced alcohol-induced liver injury by modulating the gut microbiota and metabolites.
Zhu L; Cao F; Hu Z; Zhou Y; Guo T; Yan S; Xie Q; Xia X; Yuan H; Li G; Luo F; Lin Q -- Nutrients
Cyanidin-3-O-glucoside enhances GLP-1 secretion via PPARβ/δ-β-catenin-TCF-4 pathway in type 2 diabetes mellitusEmergingCell-culture study2025
In cultured intestinal L-cells, cyanidin-3-O-glucoside raised GLP-1 secretion via the PPARbeta/delta-beta-catenin-TCF-4 pathway, promoting insulin release in co-cultured beta-cells.
Ye X; Chen W; Yan F; Zheng X; Tu P -- NPJ science of food
Malvidin-3-glucoside induces insulin secretion by activating the PLC/IP<sub>3</sub> pathway and enhancing Ca<sup>2+</sup> influx in INS-1 pancreatic β-cellsEmergingCell-culture study2025
In INS-1 beta-cells, malvidin-3-glucoside enhanced insulin secretion via the PLC/IP3 pathway and calcium influx without reducing cell viability.
Channuwong P; Yuan Y; Yao S; Bauermann FV; Cheng H; Suantawee T; Adisakwattana S -- Scientific reports
Beneficial effects of a high-anthocyanin diet versus a Westernized diet on colorectal cancer risk: a systematic review.EmergingSystematic review2026
A systematic review of 16 studies found anthocyanin-rich diets reduced oxidative stress, cancer cell growth signals, and colorectal tumor markers compared to a Western diet, which was linked to increased inflammation and tumor burden.
Vásquez A; Zúñiga P; Torres K; Quest AFG; Simón L -- Frontiers in immunology
Impact of anthocyanin-rich black rice consumption on cognitive function, inflammation and microvascular function in older adults: a crossover intervention trial.EmergingRandomized controlled trial2026
An eight-day crossover trial found anthocyanin-rich black rice intake significantly improved verbal memory in older adults.
Mekhora C; Lamport DJ; Spencer JPE -- Food & function
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Lipid Panel (Total Cholesterol, LDL, Non-HDL, Cholesterol/HDL Ratio, Triglycerides)emerging evidence
via Anthocyanins · 9 studies, 5 in people
What people often notice when this marker sits outside the usual range
Higher: The symptoms that actually travel with raised triglycerides belong to the metabolic pattern behind them -- the post-meal crash, central weight, rising blood pressure, fatty liver.
Lower: Very low total cholesterol alongside low albumin and unintended weight loss points at absorption or liver capacity, not at good health.
- Triglyceridesemerging evidence
via Anthocyanins · 9 studies, 5 in people
What people often notice when this marker sits outside the usual range
Higher: High triglycerides are usually silent and travel with the insulin-resistant pattern -- central weight gain, energy crashes after carb-heavy meals, a low HDL.
Lower: Low triglycerides are generally not a concern and often reflect good metabolic health.
- Triglyceridesemerging evidence
via Anthocyanins · 9 studies, 5 in people
What people often notice when this marker sits outside the usual range
Higher: A non-fasting draw or recent alcohol inflates the number -- confirm a true fasting sample before acting on a borderline value.
Lower: Low triglycerides are generally not a concern and often reflect good metabolic health and insulin sensitivity.
- Glucose (Fasting)emerging evidence
via Anthocyanins · 11 studies, 3 in people
Reviewed alongside curcumin and resveratrol for prevention and management of metabolic dysfunction; slow carbohydrate absorption and improve insulin sensitivity.
What people often notice when this marker sits outside the usual range
Higher: Waking at 3am, often with a racing heart -- 'why do i wake up at 3am every night'.
Lower: Shakiness, sweating, sudden anxiety and difficulty concentrating that resolve within minutes of eating.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC Meta is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC Meta pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take four softgels daily, often with a larger meal. Follow the current label for timing and serving size.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC MetaThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC Meta is a concentrated anthocyanin blend from black rice, black currant, and bilberry. Anthocyanins are the deep purple-red plant pigments studied for antioxidant support, and this formula is aimed at supporting the body's healthy response around a meal. It fits people who want antioxidant support tied to their meals.
FAQ
What does ageLOC Meta support?
It supports the body's own antioxidant defenses and a healthy inflammation response around a meal, provides a concentrated spectrum of dietary anthocyanins, and complements a balanced diet and everyday metabolic habits.
How do I take it?
Take four softgels daily, often with a larger meal. Follow the current label for timing and serving size.
What makes it different?
There is a study on the actual finished formula looking at how the body handles the oxidative load of a rich meal. It is framed as antioxidant support around meals, not weight loss or blood-sugar treatment.