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What it is
Only about 1 in 8 adults is metabolically healthy — and that is exactly the problem ageLOC Meta is built for. It is a concentrated anthocyanin blend standardized to 215 mg per serving, drawn from black rice, black currant, and bilberry and built around the two pigments the research pointed to, cyanidin and delphinidin — the deep purple-red compounds studied for metabolic and antioxidant support. Taken as four softgels daily, it is aimed squarely at the metabolic chemistry of how your body handles a meal.
Why the evidence supports it
Meta is named for metabolic chemistry, and that is the honest center of its evidence — not a generic antioxidant story. The finished blend has its own signal: subjects who took it before a rich, high-fat meal showed a more favorable metabolic and inflammatory response than placebo. Behind that, its cyanidin and delphinidin — chosen through LifeGen's gene-expression screening for their metabolic gene modulation, not antioxidant chemistry alone — reach a striking spread of metabolic systems, and the human evidence is strongest right where the name points: the liver (anthocyanin trials lower ALT and liver-injury markers in people with fatty liver), the gut (they shift the microbiome toward more short-chain-fat production and help tighten the gut barrier), plus fat oxidation and healthy insulin and glucose handling — with emerging work on the pancreas, on muscle glucose uptake, and on neuroprotection. Its anthocyanins do also switch on NRF2, which is one of these levers and where the everyday antioxidant-and-clearing piece comes in — but the headline is metabolic breadth, honestly graded: liver and microbiome rest on human trials, while the pancreas and muscle links are still emerging. Kept honest, it supports the cell's Transform function — how the body handles and clears the energy of a meal — not weight loss or a blood-sugar treatment.
What it supports
- Supports the body's own antioxidant defenses
- Supports a healthy inflammation response around a meal
- Provides a concentrated spectrum of dietary anthocyanins
- Complements a balanced diet and everyday metabolic habits
Which function it supports
Ties to the cell's Transform function — supporting metabolic chemistry across the liver, gut and microbiome, fat oxidation, and how the body handles and clears the energy of a meal.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below — follow either link to see the mechanism in full, then dig into the studies.
What it is made of — and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions — follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (4 profiled ingredients). Structure and function only — not a treatment claim.
The science on the ingredients
Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysisEstablishedMeta-analysis2023
A systematic review and meta-analysis reported that anthocyanin intake was associated with a lower Firmicutes-to-Bacteroidetes ratio and higher short-chain fatty acids, chiefly acetic acid, largely across rodent gut-health datasets.
Kapoor P; Tiwari A; Sharma S; Tiwari V; Sheoran B; Ali U; Garg M — Scientific reports
Anthocyanin-Rich Blackcurrant Extract Preserves Gastrointestinal Barrier Permeability and Reduces Enterocyte Damage but Has No Effect on Microbial Translocation and Inflammation After Exertional Heat StressEstablishedRandomized controlled trial2022
In a randomized crossover trial in twelve men, 600 mg/day anthocyanin-rich blackcurrant extract was associated with roughly 12% lower intestinal permeability and 40% less enterocyte damage after exertional heat stress.
Lee BJ; Flood TR; Hiles AM; Walker EF; Wheeler LEV; Ashdown KM; Willems MET; Costello R; Greisler LD; Romano PA; Hill GW; Kuennen MR — International journal of sport nutrition and exercise metabolism
The effect of dietary anthocyanins on biochemical, physiological, and subjective exercise recovery: a systematic review and meta-analysisEstablished2023
A systematic review and meta-analysis found dietary anthocyanins improved biochemical, physiological and subjective markers of exercise recovery.
Kimble R; Jones K; Howatson G — Critical reviews in food science and nutrition
Effects of a 24-week intervention with freeze-dried blueberries on brain health in older adults: A randomized double-blind, placebo-controlled trialEmerging2026
In a 24-week RCT in cognitively healthy older adults, freeze-dried blueberries were tested for effects on serum neuronal biomarkers (p-tau181, neurofilament light) and cognition.
Guardino ET; Gabriel O; Mukamal KJ; Djousse L — Clinical nutrition ESPEN
The effect of anthocyanins through diet and supplementation on cognitive function in older adults: a multi-centre randomised controlled clinical trialEmerging2026
In a multicentre 24-week RCT in adults aged 60-85 with memory complaints, anthocyanins from diet or supplementation were tested for effects on cognitive performance.
do Rosario V; Chan K; Lorzadeh E; Brodaty H; Anstey KJ; Kent K; Roodenrys S; Bliokas V; Phillipson L; Francois ME; Batterham MJ; Cyriac T; Weston-Green K; Jiang X; George J; Potter J; Charlton KE — Food & function
Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trialEmerging2026
In a 28-day randomized placebo-controlled trial (n=98), a composite polyphenol supplement lowered fecal microplastic concentration and altered immune markers (not anthocyanin-specific).
Zhao L; Zheng J; Shen Y; Xu X; Liu X; Yu J; Li J; Yang B; Chen L; Wang F; Liu S; Peng X; Du J; Dong R — Nature communications
Malvidin-3-glucoside induces insulin secretion by activating the PLC/IP<sub>3</sub> pathway and enhancing Ca<sup>2+</sup> influx in INS-1 pancreatic β-cellsEmerging2025
In INS-1 beta-cells, malvidin-3-glucoside enhanced insulin secretion via the PLC/IP3 pathway and calcium influx without reducing cell viability.
Channuwong P; Yuan Y; Yao S; Bauermann FV; Cheng H; Suantawee T; Adisakwattana S — Scientific reports
Cyanidin-3-O-Glucoside Alleviates Alcoholic Liver Injury via Modulating Gut Microbiota and Metabolites in MiceEmerging2024
In mice, cyanidin-3-O-glucoside (the dominant anthocyanin in black rice) reduced alcohol-induced liver injury by modulating the gut microbiota and metabolites.
Zhu L; Cao F; Hu Z; Zhou Y; Guo T; Yan S; Xie Q; Xia X; Yuan H; Li G; Luo F; Lin Q — Nutrients
Effects of protocatechuic acid on antioxidant capacity, mitochondrial biogenesis and skeletal muscle fiber transformationEmerging2023
The anthocyanin metabolite protocatechuic acid supported skeletal-muscle mitochondrial biogenesis and a shift toward oxidative (type I) muscle fibers.
Yang L; Chen X; Chen D; Yu B; He J; Luo Y; Zheng P; Chen H; Yan H; Huang Z — The Journal of nutritional biochemistry
Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trialEmerging2023
In a randomized trial in untrained adults, 18 days of blueberry supplementation raised post-exercise anti-inflammatory oxylipins after eccentric exercise.
Nieman DC; Sakaguchi CA; Omar AM; Davis KL; Shaffner CE; Strauch RC; Lila MA; Zhang Q — Scientific reports
Cyanidin-3-rutinoside stimulated insulin secretion through activation of L-type voltage-dependent Ca2+ channels and the PLC-IP3 pathway in pancreatic β-cellsEmerging2022
In cultured rat beta-cells, cyanidin-3-rutinoside, a blackcurrant anthocyanin, was associated with increased insulin secretion through L-type calcium channels and the PLC-IP3 pathway.
Kongthitilerd P; Thilavech T; Marnpae M; Rong W; Yao S; Adisakwattana S; Cheng H; Suantawee T — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cyanidin-3-O-Glucoside Ameliorates Palmitic-Acid-Induced Pancreatic Beta Cell Dysfunction by Modulating CHOP-Mediated Endoplasmic Reticulum Stress PathwaysEmerging2022
In isolated mouse islets and beta-cell cultures, cyanidin-3-O-glucoside was associated with improved insulin-secreting function and less cell death, an effect linked to dampened CHOP-driven endoplasmic reticulum stress.
Chen Y; Li X; Su L; Hu Q; Li W; He J; Zhao L — Nutrients
Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in miceEmerging2022
In high-fat-diet mice, short-term cyanidin- and delphinidin-rich extract was associated with reversal of metabolic endotoxemia and reduced hepatic TLR2, TLR4 and NF-kB inflammatory signaling, though liver fat itself was not lowered.
Cremonini E; Iglesias DE; Matsukuma KE; Hester SN; Wood SM; Bartlett M; Fraga CG; Oteiza PI — Food & function
Cyanidin and delphinidin restore colon physiology in high fat diet-fed mice: Involvement of TLR-4 and redox-regulated signalingEmerging2022
In high-fat-diet mice and Caco-2 cells, a cyanidin- and delphinidin-rich extract was associated with restored colonic tight-junction structure and lower TLR-4 and oxidative signaling, supporting gut-barrier integrity against LPS.
Iglesias DE; Cremonini E; Hester SN; Wood SM; Bartlett M; Fraga CG; Oteiza PI — Free radical biology & medicine
Cyanidin-3-O-glucoside impacts fecal discharge of polystyrene microplastics in mice: Potential role of microbiota-derived metabolitesEmerging2022
In mice, cyanidin-3-O-glucoside increased fecal excretion of polystyrene microplastics, an effect linked to microbiota-derived metabolites.
Chen W; Tu P; Ye X; Tang Q; Yu T; Zheng X — Toxicology and applied pharmacology
Cyanidin-3-O-Glucoside Supplementation Ameliorates Metabolic Insulin Resistance via Restoration of Nitric Oxide-Mediated Endothelial Insulin TransportEmerging2022
Cyanidin-3-O-glucoside supplementation improved metabolic insulin resistance by restoring nitric-oxide-mediated endothelial insulin transport to peripheral tissue.
Geng X; Ji J; Liu Y; Li X; Chen Y; Su L; Zhao L — Molecular nutrition & food research
Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in miceEmerging2022
In mice, dietary cyanidin-3-O-glucoside increased fecal discharge of ingested microplastics and modulated the gut microbiota, reducing microplastic-associated toxicity.
Chen W; Zhu R; Ye X; Sun Y; Tang Q; Liu Y; Yan F; Yu T; Zheng X; Tu P — Food & function
Dietary anthocyanins alleviate age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota-bile acid-hepatic FXR signalingEmergingAnimal study2026
In 18-month-old mice, dietary cyanidin-3-O-glucoside reduced liver fat accumulation and, by transcriptomic analysis, shifted hepatic gene expression through bile-acid FXR signaling, an animal-level nutrigenomic effect on age-related fatty liver.
Chen S; Wan C; Yu C; Shen T; Zhang H; Xiao J; You Y; Shen X; Li J; Ling W; Huang R; Xue H; Chen X — Hepatology (Baltimore, Md.)
Chokeberry reduces inflammation in human preadipocytesEmergingPreclinical study2024
In human primary preadipocytes, chokeberry anthocyanin extract lowered palmitate- and LPS-induced IL-6 gene expression and altered its epigenetic marks, showing anthocyanins can down-modulate an inflammatory gene in human fat-cell precursors.
Brunelle DC; Larson KJ; Bundy A; Roemmich JN; Warne D; Redvers N — Journal of functional foods
Antidiabetic Effects of Anthocyanins on Pancreatic β-Cell Function: A Systematic Review of In Vitro Studies.EmergingSystematic review2026
A systematic review on anthocyanins found that while effective in vitro concentrations were higher than typical circulating levels.
Kumkum R; Pathiranage TR; McNeill BA; Rivera LR; Aston-Mourney K — International journal of molecular sciences
The Effect of Anthocyanins on Cognition: A Systematic Review and Meta-analysis of Randomized Clinical Trial Studies in Cognitively Impaired and Healthy AdultsMeta-analysis2024
A meta-analysis of randomized trials found anthocyanin supplementation was associated with improvements across several cognitive domains including memory and executive function.
Authors et al. — Current Nutrition Reports
Effect of New Zealand Blackcurrant Supplementation on Sports Performance: A Systematic Review.EmergingSystematic review2026
A systematic review on anthocyanins found that NZBC supplementation may provide modest benefits for sports performance and metabolic outcomes.
Gholamian S; Ebrahimi S; Razmdideh A; Shariatzadeh M; Moeini ER — Current developments in nutrition
Hepato-Renal Axis: A Systematic Review of Anthocyanin Protective Mechanisms of Preclinical Evidence.EmergingSystematic review2026
A systematic review on anthocyanins found that anthocyanin administration decreased ALT, AST, BUN, and creatinine, enhanced antioxidant enzymes, and reduced histopathological injury via Nrf2/HO-1 activation and NF-κB suppression.
Fatima A; Sultan MT; Noman AM; Shahid B; Haroon M; Raza H — Molecular nutrition & food research
Anthocyanins on cognitionEmergingMeta-analysis2025
Selected cognitive domains improved -- Different sources tests and small studies (Anthocyanins evidence)
Lorzadeh E et al. — Current Nutrition Reports
Balanced by design — we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above — Sense, Exchange, Transform, Build, Maintain, Adapt — needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC Meta is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal — here is what ageLOC Meta pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational — a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it — go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take four softgels daily, often with a larger meal. Follow the current label for timing and serving size.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC MetaThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC Meta is a concentrated anthocyanin blend from black rice, black currant, and bilberry. Anthocyanins are the deep purple-red plant pigments studied for antioxidant support, and this formula is aimed at supporting the body's healthy response around a meal. It fits people who want antioxidant support tied to their meals.
Common questions
What does ageLOC Meta support?+
It supports the body's own antioxidant defenses and a healthy inflammation response around a meal, provides a concentrated spectrum of dietary anthocyanins, and complements a balanced diet and everyday metabolic habits.
How do I take it?+
Take four softgels daily, often with a larger meal. Follow the current label for timing and serving size.
What makes it different?+
There is a small study on the actual finished formula looking at how the body handles the oxidative load of a rich meal. It is framed as antioxidant support around meals, not weight loss or blood-sugar treatment.