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What it is
Only about 1 in 8 adults is metabolically healthy -- and that is exactly the problem ageLOC Meta is built for. It is a concentrated anthocyanin blend standardized to 215 mg per serving, drawn from black rice, black currant, and bilberry and built around the two pigments the research pointed to, cyanidin and delphinidin -- the deep purple-red compounds studied for metabolic and antioxidant support. Taken as four softgels daily, it is aimed squarely at the metabolic chemistry of how your body handles a meal.
Why the evidence supports it
Meta is named for metabolic chemistry, and that is the honest center of its evidence -- not a generic antioxidant story. The finished blend has its own signal: subjects who took it before a rich, high-fat meal showed a more favorable metabolic and inflammatory response than placebo. Behind that, its cyanidin and delphinidin -- chosen through LifeGen's gene-expression screening for their metabolic gene modulation, not antioxidant chemistry alone -- reach a striking spread of metabolic systems, and the human evidence is strongest right where the name points: the liver (anthocyanin trials lower ALT and liver-injury markers in people with fatty liver), the gut (they shift the microbiome toward more short-chain-fat production and help tighten the gut barrier), plus fat oxidation and healthy insulin and glucose handling -- with emerging work on the pancreas, on muscle glucose uptake, and on neuroprotection. Its anthocyanins do also switch on NRF2, which is one of these levers and where the everyday antioxidant-and-clearing piece comes in -- but the headline is metabolic breadth, honestly graded: liver and microbiome rest on human trials, while the pancreas and muscle links are still emerging. Kept honest, it supports the cell's Transform function -- how the body handles and clears the energy of a meal -- not weight loss or a blood-sugar treatment.
What it supports
- Supports the body's own antioxidant defenses
- Supports a healthy inflammation response around a meal
- Provides a concentrated spectrum of dietary anthocyanins
- Complements a balanced diet and everyday metabolic habits
Which function it supports
Ties to the cell's Transform function -- supporting metabolic chemistry across the liver, gut and microbiome, fat oxidation, and how the body handles and clears the energy of a meal.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (4 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision 2022-09-30Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 4 softgels | Amount | % DV |
|---|---|---|
| Calories | 15 | |
| Total Fat | 1 g | 1.5% |
| Total Carbohydrates | 1 g | 0% |
| ageLOC Meta Blendstandardized to 215 mg total anthocyanins; Black Rice (Oryza sativa L.) Extract, Black Currant (Ribes nigrum) Fruit Extract, Bilberry (Vaccinium myrtillus) Fruit Extract | 897.2 mg | † |
- Servings per container:
- 30
- Other ingredients:
- Olive Oil, Gelatin, Glycerin, Sunflower Lecithin, Beeswax.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Effects of purple corn anthocyanin on slaughter performance, immune function, the caecal microbiota and the transcriptome in chickensDOI
Poultry Science · 2025
In female chickens fed 360 mg/kg purple corn anthocyanin extract versus a basal diet, plasma immunoglobulins and complement rose and caecal microbiota and immune gene expression shifted, without changes in slaughter performance.
- Physicochemical and functional modifications induced by purple corn flour (Zea mays L.) and their sensory implications for loaf breads.PubMed
Frontiers in nutrition · 2026
Substituting 30 percent of wheat flour with purple corn flour increased bread protein, fiber, and phenolic content including gallic and chlorogenic acids, though it also increased hardness and reduced consumer sensory acceptance versus 15 percent substitution.
- Storage stability of an antioxidant tea prepared from purple corn (Zea mays L.) cob and stevia (Stevia rebaudiana Bert.) and its effects on biomarkers of oxidative stress in healthy humans.PubMed
Food research international (Ottawa, Ont.) · 2025
A purple corn and stevia antioxidant tea retained most of its polyphenol content during storage, and in healthy adults its consumption lowered two oxidative stress biomarkers over several weeks without shifting an overall oxidative stress score.
- Microencapsulation of highly concentrated polyphenolic compounds from purple corn pericarp by spray-drying with various biomacromolecules.PubMed
International journal of biological macromolecules · 2024
Spray-drying purple corn polyphenols with carrier materials like maltodextrin or gum arabic preserved their antioxidant content, offering a stable delivery form for supplements.
- Anthocyanins in metabolites of purple corn.PubMed
Frontiers in plant science · 2023
A review describes the biosynthesis pathway and gene regulation mechanisms controlling anthocyanin accumulation in purple corn, along with how environmental factors influence anthocyanin stability during crop growth.
- Linking Anthocyanin Diversity, Hue, And Genetics In Purple CornDOI
2020
Using a genetically diverse purple corn population, researchers mapped major QTL controlling anthocyanin pigment composition near known loci Pr1 and Aat1, identifying targets for breeding more stable, vividly colored natural food colorants.
The effect of anthocyanins through diet and supplementation on cognitive function in older adults: a multi-centre randomised controlled clinical trialEmergingRandomized controlled trial2026
In a multicentre 24-week RCT in adults aged 60-85 with memory complaints, anthocyanins from diet or supplementation were tested for effects on cognitive performance.
do Rosario V; Chan K; Lorzadeh E; Brodaty H; Anstey KJ; Kent K; Roodenrys S; Bliokas V; Phillipson L; Francois ME; Batterham MJ; Cyriac T; Weston-Green K; Jiang X; George J; Potter J; Charlton KE -- Food & function
Effects of a 24-week intervention with freeze-dried blueberries on brain health in older adults: A randomized double-blind, placebo-controlled trialEmergingRandomized controlled trial2026
In a 24-week RCT in cognitively healthy older adults, freeze-dried blueberries were tested for effects on serum neuronal biomarkers (p-tau181, neurofilament light) and cognition.
Guardino ET; Gabriel O; Mukamal KJ; Djousse L -- Clinical nutrition ESPEN
Aronia melanocarpa extract supplementation affects brain vascular function and cognitive performance: A randomized, double-blind, placebo-controlled, cross-over study in older adults with overweight or obesityEmergingRandomized controlled trial2026
In a randomized crossover trial in older adults at cognitive risk, 40 mg/day anthocyanins from Aronia extract for 6 weeks were tested on cerebral blood flow and cognitive performance.
Ahles S; Plat J; Nijssen KM; Joris PJ -- Clinical nutrition (Edinburgh, Scotland)
Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trialEmergingRandomized controlled trial2026
In a 28-day randomized placebo-controlled trial (n=98), a composite polyphenol supplement lowered fecal microplastic concentration and altered immune markers (not anthocyanin-specific).
Zhao L; Zheng J; Shen Y; Xu X; Liu X; Yu J; Li J; Yang B; Chen L; Wang F; Liu S; Peng X; Du J; Dong R -- Nature communications
Bilberry (Vaccinium myrtillus L.) extract alleviates gestational diabetes mellitus by coordinating TGR5/FXR signaling via a gut microbiota-bile acid axisEmergingAnimal study2026
In an animal model of gestational diabetes, bilberry extract acted through a gut microbiota-bile acid-TGR5/FXR-GLP-1 axis to support the body's own GLP-1 response.
Jiang S; Meng Q; Jiang C; Lv Y; Liu L; Xie R; Ya F; Gao Q -- Food & function
Dietary anthocyanins alleviate age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota-bile acid-hepatic FXR signalingEmergingAnimal study2026
In 18-month-old mice, dietary cyanidin-3-O-glucoside reduced liver fat accumulation and, by transcriptomic analysis, shifted hepatic gene expression through bile-acid FXR signaling, an animal-level nutrigenomic effect on age-related fatty liver.
Chen S; Wan C; Yu C; Shen T; Zhang H; Xiao J; You Y; Shen X; Li J; Ling W; Huang R; Xue H; Chen X -- Hepatology (Baltimore, Md.)
Determination of glycemic index and load of commercially available non-pigmented and pigmented rice varieties in the PhilippinesEmergingPrimary research (design unspecified)2026
In healthy Filipino adults, black rice had a significantly lower glycemic index (49) than red (69) and white rice (71), though glycemic load was similar across all three varieties.
Cecile Leah T Bayaga; Cecile Klaudine C Cabigas; Isa-Terese D Santos; Marietoni B Pico; Elisa Marie M Andaya; Rosaly V Manaois; Riza G Abilgos-Ramos
Metabolomic Based Insight Reveals a few Metabolites at Various Germination Stages of Black Rice, Demonstrating Potential Efficacy Against Dementia and Other Neurodegenerative Conditions.2026
Metabolomic analysis of germinating black rice identified phenolic metabolites that inhibited acetylcholinesterase activity in vitro, a mechanism relevant to neurotransmitter regulation studied in neurodegenerative research.
Hazra A; Hoda M; Jethwa M; Saha A; Das S -- Applied biochemistry and biotechnology
Comparative transcriptomics of anthocyanin accumulation in the pericarp of pigmented purple corn.2026
Transcriptomic analysis of purple corn identified Pl1, Lc1, P1, and Wrky33 as key regulatory genes controlling anthocyanin pigment accumulation in the corn pericarp tissue layer.
Holly AA; Michael PN; John JA -- TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
A biodegradable colorimetric sensing anthocyanin/starch film as an Indicator tag for real-time freshness indication in multiplex liquid systems.2026
Adding black rice anthocyanin pigment to starch film created a pH-responsive color-changing packaging material with reduced water vapor permeability, useful for real-time food freshness indication.
Wu N; He Y; Song W; Ren L; He Q; Zhang Q -- International journal of biological macromolecules
Development of modified starch/sodium alginate films incorporating black rice extract: Application and efficacy evaluation on coated peanut snacks.2026
A starch-alginate film loaded with black rice anthocyanin extract improved mechanical strength, thermal stability, and barrier properties, slowing lipid oxidation and improving anthocyanin retention on coated peanut snacks.
Zhou Y; Sun H; Liu S; Nagassa M; Deng Y; Kong L; Li H; Zhang R; He S -- International journal of biological macromolecules
Physicochemical and functional modifications induced by purple corn flour (Zea mays L.) and their sensory implications for loaf breads.2026
Substituting 30 percent of wheat flour with purple corn flour increased bread protein, fiber, and phenolic content including gallic and chlorogenic acids, though it also increased hardness and reduced consumer sensory acceptance versus 15 percent substitution.
Lemos IDML; de Sousa TR; Martins CPC; de Oliveira LO; Rosado CP; Sarandy GS; Pinho-Júnior JDS; Stephan MP; Teodoro AJ -- Frontiers in nutrition
Cyanidin-3-O-Glucoside Mitigates Hepatotoxicity Induced by 2-Amino-3-Methylimidazo[4,5-f]Quinoline via Endogenous and Exogenous Apoptotic Signaling Pathways: Evidence From In Vivo and In Silico Studies.EmergingAnimal study2026
In mice given the food-carcinogen IQ, cyanidin-3-O-glucoside from purple corn reduced liver injury markers ALT and AST, restored antioxidant defenses, and blocked mitochondrial and endoplasmic-reticulum apoptotic signaling pathways.
Wang S, Pan F, Xu X, et al -- Molecular nutrition & food research
Deciphering Pigmented Rice Varieties as Sustainable and Unexplored Valuable Sources of Bioactive Components With Health-Related Properties and Technological Applications-A Systematic ReviewEstablishedSystematic review2026
This systematic review found pigmented rice varieties contain bioactive compounds like anthocyanins and resistant starch with anti-inflammatory, antioxidant, and antidiabetic effects shown in vitro, in vivo, and in limited human studies.
Adolfo Pinheiro de Oliveira; Thatyane Mariano Rodrigues de Albuquerque; Evandro Leite de Souza
Tart cherry intake and serum uric acid: Meta-analysis of randomized controlled trials and evidence from network pharmacologyEstablishedMeta-analysis2026
A meta-analysis of four randomized trials found tart cherry intake produced modest serum uric acid reduction, with network analysis suggesting anthocyanins target inflammatory and metabolic pathways.
Zhang Z; Feng Z; Yan W; Wu T; Xia J; Yu J; Yang J; Wang Y; Sun G -- Asia Pacific journal of clinical nutrition
A randomised, double-blind, placebo-controlled trial to assess the postprandial dose-dependent effects of wild blueberries on metabolic and cognitive outcomes following a high-carbohydrate breakfastEstablishedRandomized controlled trial2026
In healthy adults, wild blueberry drinks lowered postprandial blood glucose and insulin and raised satiety hormones GLP-1, PYY, and GIP in a dose-dependent manner, most notably at 450 mg anthocyanins.
Lucy R Ellis; Dominic O'Connor; Haseena Khan; Louise Dye; Christine Boesch
Maqui as a Chilean Functional Food: Antioxidant Bioactivity, Nutritional Value, and Health ApplicationsEmergingExpert review2026
Maqui berry's delphinidin-rich anthocyanins modulate Nrf2-HO-1 and NF-κB pathways with cardiometabolic and nephroprotective effects on glycemic control, lipid metabolism, and endothelial function.
Caterina Tiscornia; Enrique Lorca; Carolina Estremadoyro; Valeria Aicardi; Fabián Vásquez
Dietary Polyphenols in Type 2 Diabetes: A Metabolite-Centric Review of Human EvidenceEmergingExpert review2026
Anthocyanins show the most consistent modest glycemic benefit in type 2 diabetes, while polyphenols generally function as meal-timed dietary adjuncts rather than primary agents.
Celia María Curieses Andrés; José Manuel Pérez de la Lastra; Elena Bustamante Munguira; Celia Andrés Juan; Eduardo Pérez Lebeña
Harnessing Anthocyanins to Mitigate Inflammation, Dysbiosis, and Aging in the Gastrointestinal TractEmergingExpert review2026
Anthocyanins suppressed pro-inflammatory cytokines, reduced lipopolysaccharide load, restored beneficial microbiota, and promoted short-chain fatty acid production in inflammatory bowel disease models.
Livia Resende Lopes; Adriel Aparecido de Souza; Tanila Wood Dos Santos; Raquel de Cássia Dos Santos
Anthocyanin-mediated epigenetic modifications: a new perspective in health promoting and disease preventionEmergingExpert review2026
Anthocyanins modulated DNA methylation, microRNA expression, and histone acetylation in cancer cells, inhibiting histone deacetylases and enhancing p53 acetylation to promote apoptosis.
Dongbao Cai; Yuxi Li; Dawei Sun; Yulin Zhang; Weibin Bai; Xusheng Li
The Role of Anthocyanins in Cardiovascular Health: A ReviewEmergingExpert review2026
Anthocyanin supplementation regulated blood pressure, improved lipid profiles, and enhanced endothelial function via NF-κB suppression, increased nitric oxide bioavailability, and gut microbiota modulation.
Sangeeta Yadav; Alka Sharma; Sonam Bishnoi; Mukesh Gaur; Devyani Tomar; Akash Kumar
Anthocyanins from fruit and vegetable waste: biosynthesis, extraction, and gut health benefitsEmergingExpert review2026
Waste-derived anthocyanins exhibited prebiotic-like activity, enhanced intestinal barrier integrity, and promoted short-chain fatty acid production through green extraction and encapsulation technologies.
Hudda Ayub; Husnat Ahmad; Syeda Hijab Zehra; Khadija Ramzan; Muhammad Adnan Arif; Naima Tariq; Maria Teresa Capucchio; Robert Mugabi; Aanchal Sharma; Gulzar Ahmad Nayik
Natural Bioactive Compounds in Polycystic Ovary Syndrome: Properties, Molecular Mechanisms, and Therapeutic PotentialEmergingExpert review2026
This review found that phytochemicals such as genistein and saffron petal anthocyanins reduced luteinizing hormone, testosterone, and inflammatory markers like TNF-α and IL-6 in PCOS models and trials.
Rosa Linares; Gabriela Rosas; Elizabeth Vieyra; Andrea Chaparro; Julieta-Azucena Espinoza; Deyra de Los Angeles Ramírez; Carlos-Camilo Silva; Patricia Rosas; Víctor-Manuel Macías; Leticia Morales-Ledesma
Anthocyanins from Rosaceae fruits: diversity, bioactivity, and potential as natural colorantsEmergingExpert review2026
Thirty-seven anthocyanin compounds from Rosaceae fruits demonstrated antioxidant, anti-inflammatory, and antidiabetic bioactivity across cell and animal studies.
Muhammad Habibul Ikhsan; Selvi Apriliana Putri; Herlandita Rona Anggraeni; Rika Septiyanti; Ari Hardianto; Jalifah Latip; Tati Herlina
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Lipid Panel (Total Cholesterol, LDL, Non-HDL, Cholesterol/HDL Ratio, Triglycerides)emerging evidence
via Anthocyanins · 9 studies, 5 in people
What people often notice when this marker sits outside the usual range
Higher: The symptoms that actually travel with raised triglycerides belong to the metabolic pattern behind them -- the post-meal crash, central weight, rising blood pressure, fatty liver.
Lower: Very low total cholesterol alongside low albumin and unintended weight loss points at absorption or liver capacity, not at good health.
- Triglyceridesemerging evidence
via Anthocyanins · 9 studies, 5 in people
What people often notice when this marker sits outside the usual range
Higher: High triglycerides are usually silent and travel with the insulin-resistant pattern -- central weight gain, energy crashes after carb-heavy meals, a low HDL.
Lower: Low triglycerides are generally not a concern and often reflect good metabolic health.
- Triglyceridesemerging evidence
via Anthocyanins · 9 studies, 5 in people
What people often notice when this marker sits outside the usual range
Higher: A non-fasting draw or recent alcohol inflates the number -- confirm a true fasting sample before acting on a borderline value.
Lower: Low triglycerides are generally not a concern and often reflect good metabolic health and insulin sensitivity.
- Glucose (Fasting)emerging evidence
via Anthocyanins · 11 studies, 3 in people
Reviewed alongside curcumin and resveratrol for prevention and management of metabolic dysfunction; slow carbohydrate absorption and improve insulin sensitivity.
What people often notice when this marker sits outside the usual range
Higher: Waking at 3am, often with a racing heart -- 'why do i wake up at 3am every night'.
Lower: Shakiness, sweating, sudden anxiety and difficulty concentrating that resolve within minutes of eating.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC Meta is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC Meta pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take four softgels daily, often with a larger meal. Follow the current label for timing and serving size.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC MetaThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC Meta is a concentrated anthocyanin blend from black rice, black currant, and bilberry. Anthocyanins are the deep purple-red plant pigments studied for antioxidant support, and this formula is aimed at supporting the body's healthy response around a meal. It fits people who want antioxidant support tied to their meals.
FAQ
What does ageLOC Meta support?
It supports the body's own antioxidant defenses and a healthy inflammation response around a meal, provides a concentrated spectrum of dietary anthocyanins, and complements a balanced diet and everyday metabolic habits.
How do I take it?
Take four softgels daily, often with a larger meal. Follow the current label for timing and serving size.
What makes it different?
There is a study on the actual finished formula looking at how the body handles the oxidative load of a rich meal. It is framed as antioxidant support around meals, not weight loss or blood-sugar treatment.