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$77.00 save $16.00 -- applied automatically through this link
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
A purified bovine whey extract concentrated for its low-molecular-weight molecules -- cytokines, interferon, lactoferrin, and other 'transfer factors' that act as messengers in the immune system. It is ultra-filtered to remove the large milk proteins and antibodies, leaving the small signaling molecules that support the normal, everyday communication between immune cells. It is about supporting healthy signaling, not doing your immune system's job for it.
Why the evidence supports it
The concept is grounded in how the immune system actually coordinates -- through low-molecular-weight messenger molecules like interleukins and interferon, exactly the fraction this extract concentrates. The honest framing is the strength: the goal is supporting normal immune-cell communication, not supercharging anything, and the manufacturer is upfront that the benefits have been explored in preliminary animal and clinical studies rather than large human trials. So this is a modest, mechanism-led support with an early evidence base. It ties to the cell's Maintain function -- the ordinary signaling immune cells use to stay coordinated, which is communication support only, not a treatment for any condition.
What it supports
- Supports healthy communication between immune cells
- Supports the immune system's normal everyday signaling
- Supports healthy immune-cell coordination as part of a balanced routine
- Complements a foundation of good sleep, nutrition, and minerals
Which function it supports
Ties to the cell's Maintain function via immune-cell signaling -- supporting the normal communication immune cells use to stay coordinated. This is communication support only, not a treatment for any condition.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (1 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Transcribed from the manufacturer’s official Product Information Page, exactly as printed.
| Amount per 1 capsule | Amount | % DV |
|---|---|---|
| Ai/E10 Whey Extractpurified bovine whey extract | 100 mg | ** |
- Other ingredients:
- Dicalcium Phosphate, Gelatin Capsule, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide.
Single-ingredient by label: 100 mg purified bovine whey extract (low-molecular-weight fraction under 100,000 KDa, including lactoferrin, granulocytes, cytokines, disaccharides and transfer factors).
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Effect of 5-Aminolevulinic Acid Photodynamic Therapy with Transfer Factor Capsules in the Treatment of Multiple Plantar WartsPubMed
BioMed research international · 2022
In 61 patients with multiple plantar warts, photodynamic therapy given with an immune modulator had higher 3-month success (87% vs 39%) and lower recurrence (20% vs 53%) than cryotherapy given with the same modulator.
- Effect of transfer factor on myelosuppression and related morbidity induced by chemotherapy in acute leukaemiasPubMed
British journal of haematology · 1993
Transfer factor given after chemotherapy in 22 acute leukaemia patients was associated with faster neutrophil and platelet recovery and fewer infections and bleeds, without accelerating leukaemic regrowth.
- Interferon-alpha and transfer factor in the treatment of multiple sclerosis: a double-blind, placebo-controlled trial. AUSTIMS Research GroupPubMed
Journal of neurology, neurosurgery, and psychiatry · 1989
In a three-year double-blind placebo-controlled trial of 182 multiple sclerosis patients, injected interferon-alpha or transfer factor did not slow disability progression versus placebo, and interferon-alpha caused more adverse reactions and withdrawals; funding not stated.
- Transfer factor in Hodgkin's disease: a randomized clinical and immunological studyPubMed
European journal of cancer & clinical oncology · 1988
In a randomized study of 47 Hodgkin's disease patients, transfer factor from healthy donor blood enhanced skin test reactivity versus placebo but did not show benefit in preventing infections; funding not stated.
- [Transfer factor as adjuvant immunotherapy in invasive cervix cancer. Report of a double-blind study]PubMed
1983
In a double-blind randomized trial of 60 patients with invasive cervical cancer after surgery and radiation, transfer factor immunotherapy was linked to fewer recurrences than placebo (5 of 31 vs 11 of 28).
- Randomized trial of transfer factor treatment of human wartsPubMed
Clinical and experimental immunology · 1975
In a randomized double-blind trial of 30 patients with warts, dialysed leukocyte transfer factor did not show a causal link to wart regression; funding was not stated.
Effect of 5-Aminolevulinic Acid Photodynamic Therapy with Transfer Factor Capsules in the Treatment of Multiple Plantar WartsEstablishedRandomized controlled trial2022
In 61 patients with multiple plantar warts, photodynamic therapy given with an immune modulator had higher 3-month success (87% vs 39%) and lower recurrence (20% vs 53%) than cryotherapy given with the same modulator.
Wu C; Qiu X; He C; Ci C -- BioMed research international
The role of coenzyme Q10 in exercise tolerance and muscle strengthEstablishedExpert review2025
CoQ10 role in exercise tolerance and muscle strength was reviewed supporting the importance of mitochondrial electron transport for skeletal muscle energy production during physical activity.
Bian Z et al. -- Arch Physiol Biochem
Expanding the role of alpha lipoic acid for psychiatric and neurological healthEmergingExpert review2025
The role of alpha-lipoic acid in psychiatric and neurological health was reviewed supporting the potential of lipoic acid to modulate mitochondrial redox balance in brain cellular function.
Garg I et al. -- J Asian Nat Prod Res
Alpha-lipoic Acid: An Antioxidant with Anti-aging Properties for Disease TherapyEstablishedExpert review2025
Alpha-lipoic acid antioxidant and anti-aging properties were reviewed supporting the role of lipoic acid as a mitochondrial cofactor that modulates cellular redox balance across organ systems.
Shanaida M et al. -- Curr Med Chem
Mitochondria as therapeutic targets in assisted reproductionEmergingExpert review2024
Mitochondrial function including CoQ10-dependent electron transport was reviewed as a therapeutic target in assisted reproduction supporting the role of mitochondrial energy in oocyte quality.
Yildirim RM et al. -- Hum Reprod
Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An OverviewEstablishedExpert review2024
Coenzyme Q10 supplementation was associated with support for mitochondrial electron transport function in post-viral fatigue contexts supporting the role of ubiquinone in cellular energy production.
Mantle D et al. -- Int J Mol Sci
The role of CoQ10 in embryonic developmentEmergingExpert review2024
CoQ10 role in embryonic development was reviewed supporting the importance of mitochondrial energy production and redox balance during early cell division and tissue formation.
He X et al. -- J Assist Reprod Genet
A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesisEstablishedExpert review2024
Lipoic acid biosynthesis was identified as a hub for mitochondrial metabolism regulation supporting the essential role of endogenous lipoate in coordinating fatty acid oxidation and energy transformation.
Dieckmann CL et al. -- IUBMB Life
Astragalus polysaccharide: a review of its immunomodulatory effectEmergingExpert review2022
This review found astragalus polysaccharide promotes macrophage phagocytosis, natural killer cell cytotoxicity, and dendritic cell maturation, positioning it as an immune-cell-communication component relevant to the transfer-factor-class formula lineage.
Li CX; Liu Y; Zhang YZ; Li JC; Lai J -- Archives of Pharmacal Research
Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional SupplementationEstablishedExpert review2022
The role of nutritional supplementation including alpha-lipoic acid in supporting mitochondrial function was reviewed for neurodegenerative contexts supporting mitochondrial cofactor strategies.
Mantle D et al. -- Int J Mol Sci
Is mitochondrial bioenergetics and coenzyme Q10 the target of a virus causing COVID-19?EmergingExpert review2020
Mitochondrial bioenergetics and CoQ10 were proposed as targets affected by viral infection supporting the role of ubiquinone in maintaining cellular energy during immune challenge.
Gvozdjakova A et al. -- Bratisl Lek Listy
Alpha-Lipoic Acid An Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: A Mechanistic PerspectiveEstablishedExpert review2022
Alpha-lipoic acid mechanistic perspectives in neurodegenerative disorders were reviewed supporting the role of this organosulfur molecule in modulating mitochondrial redox signaling and cellular energy.
Khan H et al. -- Neurochem Res
Transfer Factor: Myths and FactsEmergingExpert review2020
In a review, transfer factor was linked to cell-mediated immunity through induction of interferon gamma and migration inhibitory factor, and inhibition of NF-kB and TNF-alpha, though clinical results across conditions were inconsistent.
Macias AE; Guaní-Guerra E -- Archives of medical research
Mitochondrial regulation of ferroptosisEstablishedExpert review2021
Mitochondrial CoQ10 was identified as a lipid-soluble antioxidant that modulates ferroptotic cell death signaling supporting the role of ubiquinone in membrane integrity maintenance.
Gan B -- J Cell Biol
Postulated Adjuvant Therapeutic Strategies for COVID-19EmergingExpert review2020
In a review, twelve agents including zinc, selenium, vitamin C, vitamin D and immune transfer factor were postulated to act on immune regulation, viral entry, replication, inflammation, oxidative stress, clotting and endothelial mechanisms in COVID-19.
Ferreira AO; Polonini HC; Dijkers ECF -- Journal of personalized medicine
Immunological outcomes of bovine colostrum supplementation in trained and physically active people: a systematic review and meta-analysisEstablishedExpert review2020
Pooling 10 randomized controlled trials in 239 athletes and physically active adults, this meta-analysis found bovine colostrum supplementation had no or only a low impact on serum and salivary immunoglobulin and immune-cell markers.
Glowka N; Durkalec-Michalski K; Wozniewicz M -- Nutrients
Transfer Factor as an Option for Managing the COVID-19 PandemicEmergingExpert review2020
This review argued that transfer factor, an immunomodulator described as devoid of toxicity, should be tested against COVID-19 because no treatment or vaccine was expected for months.
Viza D; Pizza G; De Vinci C; Brandi G; Ablashi D -- Folia biologica
Energy Metabolism Impairment in MigraineEstablishedExpert review2019
Energy metabolism impairment involving mitochondrial dysfunction was reviewed in the context of neurological conditions with CoQ10 discussed as a mitochondrial energy supporter.
Cevoli S et al. -- Curr Med Chem
Transfer factors or dialyzable leukocyte extracts as immunomodulating peptides: a conceptual review on broad spectrum of therapeutic areas, immunologic and clinical responses, trends and perspectivesEmergingExpert review2019
This conceptual review characterized dialyzable leukocyte extracts as heterogeneous peptide mixtures under 10 kilodaltons that modulate helper T cell, natural killer cell, and cytokine activity as immune messengers.
Tulina D; Chan MKS; Michele WBF; Pan SY -- International Journal of Immunology and Immunotherapy
The Paradox of Coenzyme Q(10) in AgingEstablishedExpert review2019
The paradox of declining CoQ10 levels with aging was reviewed supporting the relationship between reduced ubiquinone status and diminished mitochondrial energy production over the lifespan.
Diaz-Casado ME et al. -- Nutrients
Lipoic acid metabolism and mitochondrial redox regulationEstablishedExpert review2018
Lipoic acid metabolism and its role in mitochondrial redox regulation were characterized supporting the function of lipoate as an enzyme cofactor in oxidative energy transformation.
Solmonson A et al. -- J Biol Chem
Mitochondrial Coenzyme Q(10) Delivery Improves Energy Production in Rat Cardiac Myoblasts and Duchenne Muscular Dystrophy Model Rat CardiomyocytesEstablishedPrimary research (design unspecified)2025
Mitochondrial CoQ10 delivery was associated with improved energy production in cardiac myoblasts supporting the role of ubiquinone supplementation in enhancing cellular ATP generation.
Sato I et al. -- Biol Pharm Bull
Alpha-lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal beta-Oxidation and Reducing Lipophagy in Chicken HepatocyteEmergingPrimary research (design unspecified)2025
Alpha-lipoic acid was associated with promoted peroxisomal beta-oxidation and modulated lipid metabolism supporting the role of lipoic acid in hepatic fatty acid transformation.
Zhao Y et al. -- Adv Sci (Weinh)
High-resolution in situ structures of mammalian respiratory supercomplexesEstablishedPrimary research (design unspecified)2024
High-resolution structures of mitochondrial respiratory supercomplexes revealed the physical arrangement of CoQ10 binding sites supporting the structural basis for electron transfer efficiency.
Zheng W et al. -- Nature
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- White Blood Cell Count & Differentialemerging evidence
via aiE10 · 11 studies, 1 in people
What people often notice when this marker sits outside the usual range
Higher: Usually an active infection -- fever, feeling unwell, a specific site that hurts.
Lower: Frequent or lingering infections; mouth ulcers; slow recovery.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. aiE10 is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what aiE10 pairs with for each. Nothing works in isolation; these share the same systems.
For Immune
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take the labeled serving with water, on the schedule on the label. Consistency day to day matters more than timing. Follow the label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get aiE10The studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
aiE10 is designed to support the normal, everyday signaling between your immune cells -- the ordinary communication your immune system uses to stay coordinated. It is about supporting healthy communication, not about doing your immune system's job for it. It fits people who want grounded, everyday immune-signaling support.
FAQ
What does aiE10 support?
It supports healthy communication between immune cells, the immune system's normal everyday signaling, and healthy immune-cell coordination as part of a balanced routine, and it complements a foundation of good sleep, nutrition, and minerals.
How do I take it?
Take the labeled serving with water, on the schedule on the label. Consistency day to day matters more than timing. Follow the label.
What makes it different?
The framing is modest and honest -- it works with your immune cells' normal signaling rather than promising to supercharge anything. That restraint is the whole point.