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When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
A purified bovine whey extract concentrated for its low-molecular-weight molecules -- cytokines, interferon, lactoferrin, and other 'transfer factors' that act as messengers in the immune system. It is ultra-filtered to remove the large milk proteins and antibodies, leaving the small signaling molecules that support the normal, everyday communication between immune cells. It is about supporting healthy signaling, not doing your immune system's job for it.
Why the evidence supports it
The concept is grounded in how the immune system actually coordinates -- through low-molecular-weight messenger molecules like interleukins and interferon, exactly the fraction this extract concentrates. The honest framing is the strength: the goal is supporting normal immune-cell communication, not supercharging anything, and the manufacturer is upfront that the benefits have been explored in preliminary animal and clinical studies rather than large human trials. So this is a modest, mechanism-led support with an early evidence base. It ties to the cell's Maintain function -- the ordinary signaling immune cells use to stay coordinated, which is communication support only, not a treatment for any condition.
What it supports
- Supports healthy communication between immune cells
- Supports the immune system's normal everyday signaling
- Supports healthy immune-cell coordination as part of a balanced routine
- Complements a foundation of good sleep, nutrition, and minerals
Which function it supports
Ties to the cell's Maintain function via immune-cell signaling -- supporting the normal communication immune cells use to stay coordinated. This is communication support only, not a treatment for any condition.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (1 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Transcribed from the manufacturer’s official Product Information Page, exactly as printed.
| Amount per 1 capsule | Amount | % DV |
|---|---|---|
| Ai/E10 Whey Extractpurified bovine whey extract | 100 mg | ** |
- Other ingredients:
- Dicalcium Phosphate, Gelatin Capsule, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide.
Single-ingredient by label: 100 mg purified bovine whey extract (low-molecular-weight fraction under 100,000 KDa, including lactoferrin, granulocytes, cytokines, disaccharides and transfer factors).
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Transfer Factor: Myths and Facts
Archives of medical research · 2020
In a review, transfer factor was linked to cell-mediated immunity through induction of interferon gamma and migration inhibitory factor, and inhibition of NF-kB and TNF-alpha, though clinical results across conditions were inconsistent.
- Transfer factor: an overlooked potential for the prevention and treatment of infectious diseases
Folia biologica · 2013
In a review, transfer factor was linked to reduced herpesvirus recurrence and was proposed as an adjunct approach for tuberculosis and HIV infection by supporting cell-mediated immunity.
- A review on transfer factor: an immune modulator
Drug Invention Today · 2013
This review summarized transfer factor as a low-molecular-weight leukocyte extract that stimulates helper T cells, natural killer cells, and macrophages, framing it within the broader cell-mediated immunity literature.
- Indications, usage, and dosage of the transfer factor
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) · 2007
In a review of clinical and animal studies, transfer factor was associated with increased IFN-gamma and RANTES expression and decreased osteopontin expression, and was used across conditions including herpes, tuberculosis, and dermatitis in protocol-based studies.
- Transfer factor--current status and future prospects
Biotherapy (Dordrecht, Netherlands) · 1996
In cell culture, dialyzable leukocyte extract fractions contained two opposing antigen-specific activities, an inducer factor that conferred antigen reactivity and a suppressor factor that blocked it in immune leukocyte cultures.
- Transfer factor: past, present and future
Annual Review of Pharmacology and Toxicology · 1989
This foundational review described transfer factor as a T-lymphocyte-derived peptide able to transmit antigen-specific and non-specific cell-mediated immune reactivity between individuals, though its precise mechanism was still undetermined.
Modulation of the immune system and the response against pathogens with bovine colostrum concentrates.2002
A review of colostrum research concluded that bovine colostrum concentrate survives digestion intact enough to act in the lower gut, and has shown some benefit against specific infections in animal and human studies, though prevention results were limited.
Solomons NW -- European journal of clinical nutrition
Effects of RRR-alpha-tocopherol on leukocyte expression of HSP72 in response to exhaustive treadmill exercise.2002
In 9 men, 8 days of vitamin E supplementation before exhaustive treadmill exercise slightly lowered a stress-protein response in white blood cells 3 hours afterward, but the difference disappeared by 24 and 48 hours.
Niess AM; Fehrenbach E; Schlotz E; Sommer M; Angres C; Tschositsch K -- International journal of sports medicine
Modulation of human humoral immune response through orally administered bovine colostrum.2001
In 18 healthy adults given an oral typhoid vaccine alongside bovine colostrum or placebo for 7 days, antibody responses did not differ significantly between groups, though colostrum recipients trended toward a greater rise in one antibody type.
He F; Tuomola E; Arvilommi H; Salminen S -- FEMS immunology and medical microbiology
Enhancement of neutrophil function by ultrafiltered bovine whey.2001
In lab tests on calf neutrophils and in periparturient dairy cows, an ultrafiltered bovine whey product increased several measures of neutrophil activity, including a key bacteria-killing mechanism, without changing overall white blood cell counts in vivo.
Roth JA; Frank DE; Weighner P; Weighner M -- Journal of dairy science
Is atherosclerosis an infectious disease?2001
A review of evidence on infection and heart disease found several bacteria and viruses, especially Chlamydia pneumoniae, were linked to atherosclerosis, but concluded prescribing antibiotics to prevent heart disease was not yet supported.
Mawhorter SD; Lauer MA -- Cleveland Clinic journal of medicine
Detection of cytokines in bovine colostrum.2000
Testing whey from cows at different lactation stages found colostrum contained significantly higher levels of several immune-signaling cytokines than later milk, with cytokine mRNA also detected directly in colostrum cells.
Hagiwara K; Kataoka S; Yamanaka H; Kirisawa R; Iwai H -- Veterinary immunology and immunopathology
Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS.1996
In 24 AIDS patients with Cryptosporidium-related diarrhea, bovine colostrum immunoglobulin in powder form reduced stool weight and frequency, while the same substance in capsule form and patients without the parasite showed no improvement.
Greenberg PD; Cello JP -- Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
Nonspecific antibacterial factors in milk from cows immunized with human oral bacterial pathogens.1992
In dairy cows immunized against oral bacteria, milk collected after calving showed rising lactoperoxidase and iron-binding activity but falling lysozyme, and purified milk proteins stopped growth of the targeted bacteria in lab tests.
Takahashi N; Eisenhuth G; Lee I; Schachtele C; Laible N; Binion S -- Journal of dairy science
Vaccination of cows with clostridial antigens and passive transfer of clostridial antibodies from bovine colostrum to lambs.1985
In cows vaccinated against clostridial bacteria, colostrum antibody levels rose with repeated vaccine courses, and feeding this colostrum to 12 newborn lambs gave them high antitoxin levels that protected them through 24 weeks of age.
Clarkson MJ; Faull WB; Kerry JB -- The Veterinary record
Development of immunity to porcine rotavirus in piglets protected from disease by bovine colostrum.1981
In piglets fed rotavirus-neutralizing bovine colostrum and exposed to the virus, the animals stayed healthy and later developed protective immunity, while piglets not given colostrum developed diarrhea and died within 6 days of infection.
Bridger JC; Brown JF -- Infection and immunity
Use of polyvalent cow colostrum in the prevention of enteric infections in calves and piglets.1978
In calves and piglets, colostrum from cows vaccinated against E. coli and gastroenteritis virus protected the young animals against enteric infection, with maternal antibody persisting in the piglet gut for about 6 hours after feeding.
Mensík J; Salajka E; Stĕpánek J; Ulmann L; Procházka Z; Dressler J -- Annales de recherches veterinaires. Annals of veterinary research
Adjuvant therapy of malignant melanomaEstablishedSystematic review2002
In a systematic review, early randomized trials of adjuvant agents including BCG, levamisole, transfer factor and vitamin A for high-risk melanoma were largely negative, while interferon showed benefit in phase III trials.
Molife R; Hancock BW -- Critical reviews in oncology/hematology
Alpha-lipoic Acid: An Antioxidant with Anti-aging Properties for Disease TherapyEstablishedExpert review2025
Alpha-lipoic acid antioxidant and anti-aging properties were reviewed supporting the role of lipoic acid as a mitochondrial cofactor that modulates cellular redox balance across organ systems.
Shanaida M et al. -- Curr Med Chem
Expanding the role of alpha lipoic acid for psychiatric and neurological healthEmergingExpert review2025
The role of alpha-lipoic acid in psychiatric and neurological health was reviewed supporting the potential of lipoic acid to modulate mitochondrial redox balance in brain cellular function.
Garg I et al. -- J Asian Nat Prod Res
Transfer factor: past, present and futureLineageExpert review1989
This foundational review described transfer factor as a T-lymphocyte-derived peptide able to transmit antigen-specific and non-specific cell-mediated immune reactivity between individuals, though its precise mechanism was still undetermined.
Fudenberg HH -- Annual Review of Pharmacology and Toxicology
The role of coenzyme Q10 in exercise tolerance and muscle strengthEstablishedExpert review2025
CoQ10 role in exercise tolerance and muscle strength was reviewed supporting the importance of mitochondrial electron transport for skeletal muscle energy production during physical activity.
Bian Z et al. -- Arch Physiol Biochem
Mitochondria as therapeutic targets in assisted reproductionEmergingExpert review2024
Mitochondrial function including CoQ10-dependent electron transport was reviewed as a therapeutic target in assisted reproduction supporting the role of mitochondrial energy in oocyte quality.
Yildirim RM et al. -- Hum Reprod
Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An OverviewEstablishedExpert review2024
Coenzyme Q10 supplementation was associated with support for mitochondrial electron transport function in post-viral fatigue contexts supporting the role of ubiquinone in cellular energy production.
Mantle D et al. -- Int J Mol Sci
The role of CoQ10 in embryonic developmentEmergingExpert review2024
CoQ10 role in embryonic development was reviewed supporting the importance of mitochondrial energy production and redox balance during early cell division and tissue formation.
He X et al. -- J Assist Reprod Genet
A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesisEstablishedExpert review2024
Lipoic acid biosynthesis was identified as a hub for mitochondrial metabolism regulation supporting the essential role of endogenous lipoate in coordinating fatty acid oxidation and energy transformation.
Dieckmann CL et al. -- IUBMB Life
Astragalus polysaccharide: a review of its immunomodulatory effectEmergingExpert review2022
This review found astragalus polysaccharide promotes macrophage phagocytosis, natural killer cell cytotoxicity, and dendritic cell maturation, positioning it as an immune-cell-communication component relevant to the transfer-factor-class formula lineage.
Li CX; Liu Y; Zhang YZ; Li JC; Lai J -- Archives of Pharmacal Research
Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional SupplementationEstablishedExpert review2022
The role of nutritional supplementation including alpha-lipoic acid in supporting mitochondrial function was reviewed for neurodegenerative contexts supporting mitochondrial cofactor strategies.
Mantle D et al. -- Int J Mol Sci
Is mitochondrial bioenergetics and coenzyme Q10 the target of a virus causing COVID-19?EmergingExpert review2020
Mitochondrial bioenergetics and CoQ10 were proposed as targets affected by viral infection supporting the role of ubiquinone in maintaining cellular energy during immune challenge.
Gvozdjakova A et al. -- Bratisl Lek Listy
Alpha-Lipoic Acid An Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: A Mechanistic PerspectiveEstablishedExpert review2022
Alpha-lipoic acid mechanistic perspectives in neurodegenerative disorders were reviewed supporting the role of this organosulfur molecule in modulating mitochondrial redox signaling and cellular energy.
Khan H et al. -- Neurochem Res
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- White Blood Cell Count & Differentialemerging evidence
via aiE10 · 11 studies, 1 in people
What people often notice when this marker sits outside the usual range
Higher: Usually an active infection -- fever, feeling unwell, a specific site that hurts.
Lower: Frequent or lingering infections; mouth ulcers; slow recovery.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. aiE10 is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what aiE10 pairs with for each. Nothing works in isolation; these share the same systems.
For Immune
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take the labeled serving with water, on the schedule the brand suggests. Consistency day to day matters more than timing. Follow the label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get aiE10The studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
aiE10 is designed to support the normal, everyday signaling between your immune cells -- the ordinary communication your immune system uses to stay coordinated. It is about supporting healthy communication, not about doing your immune system's job for it. It fits people who want grounded, everyday immune-signaling support.
FAQ
What does aiE10 support?
It supports healthy communication between immune cells, the immune system's normal everyday signaling, and healthy immune-cell coordination as part of a balanced routine, and it complements a foundation of good sleep, nutrition, and minerals.
How do I take it?
Take the labeled serving with water, on the schedule the brand suggests. Consistency day to day matters more than timing. Follow the label.
What makes it different?
The framing is modest and honest -- it works with your immune cells' normal signaling rather than promising to supercharge anything. That restraint is the whole point.