When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
High-purity marine omega-3 fatty acids — EPA and DHA — drawn from ultra-pure fish oil plus krill oil, which carries these fats in a phospholipid form the body reads easily. It is tested under a 6S quality process to be free of harmful levels of toxins and heavy metals, and it includes mixed tocopherols (vitamin E) to keep the oil fresh. These are the fats that get built directly into your cell membranes, the thin outer layer where cells sense the world and pass signals.
Why the evidence supports it
Omega-3 status is one of the most consistently studied nutrition markers there is, and most modern diets run measurably low on EPA and DHA. The research ties adequate intake to healthy cell-membrane structure and a normal inflammation response — and it also shows these fats oxidize easily, so the purity and freshness of the source genuinely matter. A marine oil tested for both is what the evidence points to.
What it supports
- Supports healthy cell membrane structure
- Supports a healthy inflammation response already within normal range
- Supports normal heart and brain function as part of a balanced diet
- Provides EPA and DHA that diets often lack
Which function it supports
Ties to the cell's Build function via the cell membrane — omega-3s become part of the membrane itself, which is where cellular signaling and exchange play out.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below — follow either link to see the mechanism in full, then dig into the studies.
What it is made of — and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions — follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (5 profiled ingredients). Structure and function only — not a treatment claim.
The science on the ingredients
Effects of seal oil supplementation on lipid profile biomarkers: A systematic review and meta-analysis of randomized controlled trials.EmergingMeta-analysis2025
A meta-analysis of seal oil supplementation examined effects on lipid-profile biomarkers, concluding further evidence is needed to confirm consistent effects.
Gallo Ruelas M; Queiroz I; Pimentel T; Tavares AH; Defante MLR; Barbosa LM; Eckert I — Prostaglandins, leukotrienes, and essential fatty acids
A systematic review and dose response meta-analysis of Omega-3 supplementation on cognitive functionMeta-analysis2024
A dose-response meta-analysis found that omega-3 supplementation was associated with modest cognitive benefits that varied by dose and baseline cognitive status.
Authors et al. — PMC (systematic review)
Omega-3 fatty acid supplementation in solid organ transplant recipients: A systematic review and meta-analysis of randomized controlled trials.EmergingMeta-analysis2025
A meta-analysis found omega-3 supplementation in solid organ transplant recipients was associated with improved lipid profiles and reduced blood pressure, pending larger trials.
Samankan S; Gharekhani A; Khiali S; Rezagholizadeh A; Agabalazadeha A; Sarbakhsh P; Alizadeh L; Sharifi A — Clinical nutrition ESPEN
Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation.EmergingMeta-analysis2023
Data on omega-3 fatty acid biomarkers suggest habitual dietary omega-3 intake is not associated with increased atrial fibrillation risk.
Qian F; Tintle N; Jensen PN; Lemaitre RN; Imamura F; Feldreich TR; Nomura SO; Guan W — Journal of the American College of Cardiology
Recent advances in DHA-containing phospholipids (PL-DHA): Sources, position-specific effects, metabolic pathways, and biological activities.EmergingExpert review2025
DHA-containing phospholipids exert anti-inflammatory and neuroprotective activity through direct membrane effects and bioactive metabolite generation, informing structure-function relationships in cell biology.
He Y; Liu B; Ma X; Hu X; Yan W; Wang F — Food research international (Ottawa, Ont.)
Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.EmergingExpert review2025
Ginkgo biloba, ginger, ginseng, and curcumin show anti-inflammatory vascular activity but may also increase bleeding risk when combined with antithrombotic therapy.
Dobre MZ; Virgolici B; Doicin IC; Vîrgolici H; Stanescu-Spinu II — International journal of molecular sciences
Impact of wall materials and DHA sources on the release, digestion and absorption of DHA microcapsules: Advancements, challenges and future directions.EmergingExpert review2024
Algal-oil-derived DHA microcapsules show higher lipid digestibility and free fatty acid absorptivity compared with fish-oil-derived DHA sources in digestion models.
Jiang M; Hu Z; Huang Y; Chen XD; Wu P — Food research international (Ottawa, Ont.)
The essential role of docosahexaenoic acid and its derivatives for retinal integrity.EmergingExpert review2023
DHA and its derivatives maintain retinal membrane structure, with PUFA involvement studied across retinal cell integrity and photoreceptor membrane composition.
Swinkels D; Baes M — Pharmacology & therapeutics
Protectins: Their biosynthesis, metabolism and structure-functions.EmergingExpert review2022
Forty-three specialized pro-resolving mediators have been characterized for their structure and function, forming the basis of resolution pharmacology as a drug-discovery framework.
Vidar Hansen T; Serhan CN — Biochemical pharmacology
Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints.EmergingCohort study2025
A cohort study compared icosapent ethyl to standard omega-3 fatty acids on atrial fibrillation and major bleeding endpoints in a veterans population.
Patil T; Gregory M; Savona N; Jarmukli N; Leonard CE — Clinical drug investigation
Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife2022
Higher red blood cell omega-3 levels in midlife were associated with more favorable brain MRI markers and cognitive test scores years later.
Zhang Y, et al. — Neurology
EPA and DHA containing phospholipids have contrasting effects on membrane structureEmergingPreclinical study2021
Using X-ray diffraction on model membranes, EPA and DHA phospholipids changed membrane electron density and ordering differently, showing the two omega-3s occupy distinct physical positions in the bilayer.
Sherratt SCR, Juliano RA, Copland C, Bhatt DL, Libby P, Mason RP — Journal of Lipid Research
EPA and DHA differentially modulate membrane elasticity in the presence of cholesterolEmergingPreclinical study2021
In synthetic membrane vesicles, EPA and DHA produced different changes in membrane bending and elasticity when cholesterol was present, indicating the two omega-3 fatty acids are not interchangeable for membrane physical properties.
Jacobs ML, Faizi HA, Peruzzi JA, Vlahovska PM, Kamat NP — Biophysical Journal
Equal bioavailability of omega-3 PUFA from Calanus oil, fish oil and krill oil: A 12-week randomized parallel study.EmergingRandomized controlled trial2023
A randomized controlled trial on Omega-3 EPA/DHA found that at baseline, the three groups showed comparable (mean ± SD) O3I values (CO: 5.13 ± 1.12%, FO: 4.90 ± 0.57%, KO: 4.87 ± 0.77%).
Vosskötter F; Burhop M; Hahn A; Schuchardt JP — Lipids
Eicosapentaenoic acid inhibits cholesterol efflux pathways from cholesterol-loaded human THP-1 macrophages by reducing the hydrolysis of cholesteryl esters mediated by carboxylesterase 1.ContestedClinical trial2025
A clinical trial on Omega-3 EPA/DHA found that the diminished cholesterol efflux was not related to triglyceride accumulation or to variations in apo E secretion.
Nowak M; Dakroub H; Noël B; Rousseau-Ralliard D; Slimene S; Abi-Saleh N; Benardeau M; Vedie B; Cassard AM; Paul JL; Fournier N — Biochimica et biophysica acta. Molecular and cell biology of lipids
Comparative membrane incorporation of omega-3 fish oil triglyceride preparations differing by degree of re-esterification: A sixteen-week randomized intervention trialRandomized controlled trial2023
Different omega-3 triglyceride formulations vary in how efficiently EPA, DPA, and DHA are incorporated into red blood cell membrane phospholipids over 16 weeks.
Minton ST, Almada AL, Evans JL, Laidlaw M, Opheim J — PLoS One
Eicosapentaenoic acid reprograms cerebrovascular metabolism and impairs repair after brain injury, with relevance to chronic traumatic encephalopathy.2026
In a fish-oil diet model, EPA accumulated in the brain but was depleted after repetitive mild brain injury, coinciding with impaired vascular repair and angiogenesis relevant to chronic traumatic encephalopathy.
Karakaya E; Berber B; Eskiocak O; Edwards J; Barker RB; Jamil S; Li W; Abdul Y; Ericsson M; Stein T; McKee A; Ergul A; Beyaz S; Albayram O — Cell reports
Eicosapentaenoic acid attenuates hyperoxia-induced lung injury via p38 MAPK/NF-κB-mediated regulation of glycolytic reprogramming.2026
In cell and animal models of hyperoxia-induced lung injury, eicosapentaenoic acid reduced damage by regulating p38 MAPK/NF-kB signaling and glycolytic reprogramming, building on lung-protective effects seen in COPD and asthma models.
Chen S; Gan L; Qu S; Yu K; Guo H; Lai R; Cui J; Li Y — International immunopharmacology
Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization.2026
In mice, chronic restraint stress worsened periodontitis by altering oral microbiota and depleting eicosapentaenoic acid, while EPA supplementation reduced periodontitis severity linked to M1 macrophage polarization.
Luo S; Lou F; Yang P; Zhang Y; Yan L; Dong Y; Yang B; Wang H; Liu Y; Pu J; Cannon RD; Xie P; Ji P; Jin X — Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives.2025
Specialized pro-resolving mediators help shut down inflammation and restore tissue homeostasis after acute injury, and disrupted biosynthesis of these mediators is implicated in chronic rheumatic and autoimmune conditions.
Vomero M; Lamberti L; Corberi E; Currado D; Marino A; Berardicurti O; Fava M; Leuti A; Maccarrone M; Giacomelli R; Navarini L — Autoimmunity reviews
Effect of eicosapentaenoic acid on innate immune responses in Atlantic salmon cells infected with infectious salmon anemia virus.2025
In Atlantic salmon cells, higher EPA concentrations combined with viral infection activated ferroptosis-related gene expression and oxygen radical formation pathways, a pattern not seen with EPA or infection alone, suggesting ferroptosis may limit viral replication.
Holmlund I; Ahmadi S; Ruyter B; Østbye TK; Bou M; Gjøen T — Virology journal
Eicosapentaenoic Acid (EPA) Alleviates LPS-Induced Oxidative Stress via the PPARα-NF-κB Axis.2025
In LPS-stimulated macrophages, EPA reduced inflammatory cytokines including IL-1b and oxidative stress, acting through the PPARalpha-NF-kB axis relevant to metabolic endotoxemia linked to obesity and type 2 diabetes.
AlAbduljader H; AlSaeed H; Alrabeea A; Sulaiman A; Haider MJA; Al-Mulla F; Ahmad R; Al-Rashed F — Oxidative medicine and cellular longevity
From Fish Oil to Resolution: A Narrative Review on the Potential of SPM-Enriched Marine Oil for Exercise-Induced Muscle Damage Recovery.2025
A narrative review describes how specialized pro-resolving mediators derived from omega-3 fatty acids may accelerate muscle repair after exercise-induced damage by clearing apoptotic cells and modulating macrophage polarization.
de Souza LC; Moris JM; Gordon PM; Heileson JL; Funderburk LK — Nutrients
Eicosapentaenoic acid enhances intestinal stem cell-mediated colonic epithelial regeneration by activating the LSD1-WNT signaling pathway.2025
In mice with DSS-induced colitis, EPA upregulated GPR120 to induce LSD1 expression, activating WNT signaling to increase intestinal stem cell proliferation and differentiation and reduce inflammatory cytokine levels.
Wang D; Wu N; Li P; Zhang X; Xie W; Li S; Wang D; Kuang Y; Chen S; Liu Y — Journal of advanced research
Balanced by design — we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above — Sense, Exchange, Transform, Build, Maintain, Adapt — needs the same broad base of optimal micronutrient levels running underneath it, all the time. Marine Omega is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal — here is what Marine Omega pairs with for each. Nothing works in isolation; these share the same systems.
For Foundation Nutrition
For Brain & Sleep
For Women's Health
For Mood & Hormones
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational — a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it — go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take the daily serving with a meal that contains some fat to help absorption. If you notice any fishy aftertaste, taking it with food or keeping it refrigerated usually helps.
Where to get it
We are lining up the best way to get this one to you. In the meantime, reach out and we will point you the right way — or browse the full shop to see every product.
See the full shopThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Marine Omega delivers high-purity marine omega-3 fatty acids (EPA and DHA) from fish. These are the fats built directly into your cell membranes, the thin outer layer where cells sense the world and pass signals. It is a simple upgrade for the many people whose diets run low on omega-3s.
Common questions
What does Marine Omega support?+
It supports healthy cell membrane structure, a healthy inflammation response already within normal range, and normal heart and brain function as part of a balanced diet, while providing EPA and DHA that diets often lack.
How do I take it?+
Take the daily serving with a meal that contains some fat to help absorption. If you notice any fishy aftertaste, taking it with food or keeping it refrigerated usually helps.
What makes it different?+
It is a marine source tested for purity and freshness, rather than a cheaper oil that can oxidize. Clean, well-sourced omega-3s feed the membrane where signaling and exchange happen.