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What it is
High-purity marine omega-3 fatty acids -- EPA and DHA -- drawn from ultra-pure fish oil plus krill oil, which carries these fats in a phospholipid form the body reads easily. It is tested under a 6S quality process to be free of harmful levels of toxins and heavy metals, and it includes mixed tocopherols (vitamin E) to keep the oil fresh. These are the fats that get built directly into your cell membranes, the thin outer layer where cells sense the world and pass signals.
Why the evidence supports it
Omega-3 status is one of the most consistently studied nutrition markers there is, and most modern diets run measurably low on EPA and DHA. The research ties adequate intake to healthy cell-membrane structure and a normal inflammation response -- and it also shows these fats oxidize easily, so the purity and freshness of the source genuinely matter. A marine oil tested for both is what the evidence points to.
What it supports
- Supports healthy cell membrane structure
- Supports a healthy inflammation response already within normal range
- Supports normal heart and brain function as part of a balanced diet
- Provides EPA and DHA that diets often lack
Which function it supports
Ties to the cell's Build function via the cell membrane -- omega-3s become part of the membrane itself, which is where cellular signaling and exchange play out.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision 2015Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 2 softgels | Amount | % DV |
|---|---|---|
| Total Calories | 20 | |
| Total Fat | 2 g | 3% |
| Saturated Fat | 0.5 g | 2% |
| Cholesterol | 0 mg | 0% |
| Marine Lipid ConcentrateEPA 300 mg; DHA 200 mg; Other Omega-3 Fatty Acids 100 mg | 2,200 mg | ** |
| Krill oil | 100 mg | ** |
- Servings per container:
- 60
- Other ingredients:
- Capsule (Gelatin, Glycerin, Purified Water, Caramel Color, Vanillin), Mixed Tocopherols (as antioxidant).
Differs from Optimum Omega by the addition of krill oil, and has double the softgels per bottle.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Meta-analysis of DHA and EPA supplementation on cardiovascular outcomes and atrial fibrillation risk
Pharmacology Research & Perspectives · 2026
Selected high-dose purified EPA subgroups had MACE signals -- No broad MACE or atrial-fibrillation benefit for combined moderate-dose EPA+DHA; high doses may increase AF
- Role of EPA to DHA dosing ratio on blood fatty acids and inflammation
Nutrition Reviews · 2025
Changed blood fatty-acid profiles and reduced selected inflammatory markers -- Biomarker effects varied by ratio population and total dose
- DHA Alone, EPA + DHA, EPA + DHA + GLA, and EPA + DHA with or Without Vitamin D During Chemotherapy in Women with Breast Cancer: An Intervention- and Outcome-Stratified Systematic Review
Nutrients · 2026
In review, omega-3 supplementation formulations (DHA alone, EPA+DHA combinations, with or without vitamin D) during breast cancer chemotherapy showed variable intervention outcomes.
- EPA Assessment of Risks from Radon in Homes
U.S. EPA · 2025
EPA's risk assessment identifies indoor radon gas as the second leading cause of lung cancer in the US after smoking, supporting home radon testing as a straightforward reduced-exposure step.
- Microalgal oil as an alternative source of essential nutrients omega-3 DHA and EPA
2024
In a randomized trial of 74 healthy adults, blood phospholipid levels of EPA and DHA were statistically the same after 6 and 14 weeks of supplementation with microalgal oil compared to fish oil, supporting microalgae as an alternative source.
- Monocyte transcriptomic profile following EPA and DHA supplementation in men and women with low-grade chronic inflammation
Atherosclerosis · 2024
In 16 adults with low-grade inflammation given omega-3 EPA or DHA versus placebo, both fatty acids altered monocyte gene expression, but men and women showed distinct patterns, which may help explain inconsistent omega-3 trial results by sex.
Effects of seal oil supplementation on lipid profile biomarkers: A systematic review and meta-analysis of randomized controlled trials.EmergingMeta-analysis2025
A meta-analysis of seal oil supplementation examined effects on lipid-profile biomarkers, concluding further evidence is needed to confirm consistent effects.
Gallo Ruelas M; Queiroz I; Pimentel T; Tavares AH; Defante MLR; Barbosa LM; Eckert I -- Prostaglandins, leukotrienes, and essential fatty acids
A systematic review and dose response meta-analysis of Omega-3 supplementation on cognitive functionMeta-analysis2024
A dose-response meta-analysis found that omega-3 supplementation was associated with modest cognitive benefits that varied by dose and baseline cognitive status.
Hossein Shahinfar; Zahra Yazdian; Neda Asgari Avini; Kimia Torabinasab; Sakineh Shab-Bidar -- PMC (systematic review)
Omega-3 fatty acid supplementation in solid organ transplant recipients: A systematic review and meta-analysis of randomized controlled trials.EmergingMeta-analysis2025
A meta-analysis found omega-3 supplementation in solid organ transplant recipients was associated with improved lipid profiles and reduced blood pressure, pending larger trials.
Samankan S; Gharekhani A; Khiali S; Rezagholizadeh A; Agabalazadeha A; Sarbakhsh P; Alizadeh L; Sharifi A -- Clinical nutrition ESPEN
A systematic review and meta-analysis of randomized controlled trials to evaluate plant-based omega-3 polyunsaturated fatty acids in nonalcoholic fatty liver disease patient biomarkers and parameters.EmergingMeta-analysis2024
A systematic review and meta-analysis of six trials with 362 patients found plant-based omega-3 fatty acid supplementation, combined with lifestyle changes, significantly reduced ALT and triglyceride levels in nonalcoholic fatty liver disease.
Moore E; Patanwala I; Jafari A; Davies IG; Kirwan RP; Newson L; Mazidi M; Lane KE -- Nutrition reviews
Bleeding Risk in Patients Receiving Omega-3 Polyunsaturated Fatty Acids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.EmergingMeta-analysis2024
A meta-analysis of over 120,000 patients across 11 trials found no overall increase in bleeding with omega-3 supplements, but high-dose purified EPA was linked to a modest but significant rise in bleeding risk.
Javaid M; Kadhim K; Bawamia B; Cartlidge T; Farag M; Alkhalil M -- Journal of the American Heart Association
Does omega-3 PUFAs supplementation improve metabolic syndrome and related cardiovascular diseases? A systematic review and meta-analysis of randomized controlled trials.EmergingMeta-analysis2024
A meta-analysis of 48 RCTs involving 8,489 subjects found omega-3 PUFA supplementation significantly reduced triglyceride levels, a core lipid-metabolism marker.
Wang Y; Wang Y; Shehzad Q; Su Y; Xu L; Yu L; Zeng W; Fang Z -- Critical reviews in food science and nutrition
Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation.EmergingMeta-analysis2023
Data on omega-3 fatty acid biomarkers suggest habitual dietary omega-3 intake is not associated with increased atrial fibrillation risk.
Qian F; Tintle N; Jensen PN; Lemaitre RN; Imamura F; Feldreich TR; Nomura SO; Guan W -- Journal of the American College of Cardiology
Comparative Effects of Different Nutritional Supplements on Inflammation, Nutritional Status, and Clinical Outcomes in Colorectal Cancer Patients: A Systematic Review and Network Meta-Analysis.EmergingMeta-analysis2023
A network meta-analysis of nutritional supplements found glutamine ranked highest for reducing hospital stay length and wound infection incidence among cancer patients.
Ye J; Hu Y; Chen X; Chang C; Li K -- Nutrients
Efficacy of phospholipid-bound omega-3 versus standard omega-3 in patients with hypertriglyceridemia: a randomized clinical trial.EmergingRandomized controlled trial2026
In a small pilot trial of 44 adults with mildly elevated triglycerides, phospholipid-bound omega-3 did not significantly outperform standard omega-3 for lowering triglycerides or omega-3 index after 12 weeks.
Urina-Triana M; David-Pardo DG; Urina-Triana M; Valencia J; Bernal-Martínez A; Urina-Jassir D; Orozco-Acosta E; Elajami TK -- BMC complementary medicine and therapies
Re-Esterified Triglyceride ω-3 Fatty Acids in Dry Eye Disease With Meibomian Gland Dysfunction: A Randomized Clinical Trial.EmergingRandomized controlled trial2024
In a randomized trial of 132 patients with dry eye from meibomian gland dysfunction, omega-3 fatty acids did not significantly improve symptoms compared to grape-seed oil after 12 weeks, though the study was small.
Eom Y; Jun I; Jeon HS; Lim DH; Lee H; Hwang HS; Chung SH; Chung TY -- JAMA ophthalmology
Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.EmergingExpert review2025
Ginkgo biloba, ginger, ginseng, and curcumin show anti-inflammatory vascular activity but may also increase bleeding risk when combined with antithrombotic therapy.
Dobre MZ; Virgolici B; Doicin IC; Vîrgolici H; Stanescu-Spinu II -- International journal of molecular sciences
Erythrocyte Membrane Fluidity and Omega-3 Fatty Acid Intake: Current Outlook and Perspectives for a Novel, Nutritionally Modifiable Cardiovascular Risk FactorExpert review2024
Omega-3 fatty acid intake is linked to greater red blood cell membrane fluidity, a structural property of the cell membrane.
Capece U, Gugliandolo S, Morciano C, Avolio A, Splendore A, Di Giuseppe G, Ciccarelli G, Soldovieri L, Brunetti M, Mezza T, Pontecorvi A, Giaccari A, Cinti F -- Nutrients
Recent advances in DHA-containing phospholipids (PL-DHA): Sources, position-specific effects, metabolic pathways, and biological activities.EmergingExpert review2025
DHA-containing phospholipids exert anti-inflammatory and neuroprotective activity through direct membrane effects and bioactive metabolite generation, informing structure-function relationships in cell biology.
He Y; Liu B; Ma X; Hu X; Yan W; Wang F -- Food research international (Ottawa, Ont.)
Dose-response meta-analysis of omega-3 fatty acid intake and blood pressureExpert review2022
A dose-response meta-analysis of 71 trials (4,973 people) found omega-3 intake of 2 to 3 grams per day linked to modest average blood pressure reductions, with a stronger effect in hypertensive, hyperlipidemic, and older subgroups.
Zhang X et al. -- J Am Heart Assoc
Impact of wall materials and DHA sources on the release, digestion and absorption of DHA microcapsules: Advancements, challenges and future directions.EmergingExpert review2024
Algal-oil-derived DHA microcapsules show higher lipid digestibility and free fatty acid absorptivity compared with fish-oil-derived DHA sources in digestion models.
Jiang M; Hu Z; Huang Y; Chen XD; Wu P -- Food research international (Ottawa, Ont.)
The essential role of docosahexaenoic acid and its derivatives for retinal integrity.EmergingExpert review2023
DHA and its derivatives maintain retinal membrane structure, with PUFA involvement studied across retinal cell integrity and photoreceptor membrane composition.
Swinkels D; Baes M -- Pharmacology & therapeutics
Protectins: Their biosynthesis, metabolism and structure-functions.EmergingExpert review2022
Forty-three specialized pro-resolving mediators have been characterized for their structure and function, forming the basis of resolution pharmacology as a drug-discovery framework.
Vidar Hansen T; Serhan CN -- Biochemical pharmacology
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition.EmergingExpert review2022
E-series resolvins E1 through E4 are biosynthesized from EPA through defined enzymatic pathways that regulate inflammation resolution at the cellular level.
Serhan CN; Libreros S; Nshimiyimana R -- Seminars in immunology
Dietary docosahexaenoic acid inhibits neurodegeneration and prevents stroke.EmergingExpert review2021
DHA and its derivative neuroprotectin D1 act on neuronal membranes to block cellular damage pathways associated with ischemic and degenerative neural injury.
Yamagata K -- Journal of neuroscience research
Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints.EmergingCohort study2025
A cohort study compared icosapent ethyl to standard omega-3 fatty acids on atrial fibrillation and major bleeding endpoints in a veterans population.
Patil T; Gregory M; Savona N; Jarmukli N; Leonard CE -- Clinical drug investigation
Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife2022
Higher red blood cell omega-3 levels in midlife were associated with more favorable brain MRI markers and cognitive test scores years later.
Zhang Y, et al. -- Neurology
EPA and DHA containing phospholipids have contrasting effects on membrane structureEmergingPreclinical study2021
Using X-ray diffraction on model membranes, EPA and DHA phospholipids changed membrane electron density and ordering differently, showing the two omega-3s occupy distinct physical positions in the bilayer.
Sherratt SCR, Juliano RA, Copland C, Bhatt DL, Libby P, Mason RP -- Journal of Lipid Research
Dietary supplementations to mitigate the cardiopulmonary effects of air pollution toxicity: A systematic review of clinical trialsEstablishedSystematic review2024
Systematic review of 18 clinical trials found fish oil offered limited protection against air pollution-induced pulmonary dysfunction; vitamin C and E combination protected against pulmonary dysfunction but showed conflicting cardiovascular results.
Mehran Ilaghi; Fatemeh Kafi; Mohadeseh Shafiei; Moein Zangiabadian; Mohammad Javad Nasiri
Maternal characteristics associated with ovalbumin concentrations in breast milkEstablishedRandomized controlled trial2026
In 66 atopic breastfeeding women, gestational diabetes and pregnancy fish oil use were both associated with higher breast milk ovalbumin after eating an egg, while pre-pregnancy body mass index was not.
Sophie A Hughes; Jessica R Metcalfe; Sharon L Perrella; Donna T Geddes; Debra J Palmer
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Omega-3/Omega-6 Fatty Acid Panel (EPA, DHA, DPA, Arachidonic Acid, Linoleic Acid, Ratios)solid evidence
via EPA (Omega-3) · 102 studies, 42 in people
The only thing that reliably raises the omega-3 index, because the index measures them.
What people often notice when this marker sits outside the usual range
Higher: Very high intakes: easier bruising, longer bleeding from small cuts, and a fishy aftertaste or reflux.
Lower: Dry, rough or bumpy skin on the backs of the arms; dry eyes; dry, brittle hair.
- Triglyceridessolid evidence
via EPA (Omega-3) · 24 studies, 19 in people
What people often notice when this marker sits outside the usual range
Higher: High triglycerides are usually silent and travel with the insulin-resistant pattern -- central weight gain, energy crashes after carb-heavy meals, a low HDL.
Lower: Low triglycerides are generally not a concern and often reflect good metabolic health.
- Triglyceridessolid evidence
via EPA (Omega-3) · 24 studies, 19 in people
What people often notice when this marker sits outside the usual range
Higher: A non-fasting draw or recent alcohol inflates the number -- confirm a true fasting sample before acting on a borderline value.
Lower: Low triglycerides are generally not a concern and often reflect good metabolic health and insulin sensitivity.
- Triglyceride : HDL Ratio (calculated -- a derived value)solid evidence
via EPA (Omega-3) · 24 studies, 19 in people
What people often notice when this marker sits outside the usual range
Lower: A low ratio suggests good insulin sensitivity -- the favourable direction.
via EPA (Omega-3) · 24 studies, 19 in people
What people often notice when this marker sits outside the usual range
Higher: The TyG index is a calculated insulin-resistance marker built from fasting triglycerides and fasting glucose -- a derived number, not a felt symptom.
Lower: A lower TyG index (within a population) is the favourable direction -- the validating studies read it as higher-versus-lower, not against a fixed line.
- Sperm Motility (Total & Progressive)emerging evidence
via DHA (Omega-3) · 355 studies, 205 in people
What people often notice when this marker sits outside the usual range
Lower: Silent. Found only on semen analysis.
- Omega-3 Fatty Acids (Gut/Microbiome)emerging evidence
via EPA (Omega-3) · 223 studies, 86 in people
What people often notice when this marker sits outside the usual range
Lower: An intervention entry. In the gut context the claim is that omega-3s support barrier function and shift the microbiome toward SCFA-producing genera.
- LDL-C (LDL Cholesterol)mixed evidence
via EPA (Omega-3) · 24 studies, 19 in people
What people often notice when this marker sits outside the usual range
Higher: A high LDL-C is an ESTIMATE that a lot of cholesterol cargo is riding in your LDL particles.
Lower: A low LDL-C is generally favourable, but on its own it is a start, not an answer -- pair it with ApoB to know the real particle burden.
- Non-HDL Cholesterolmixed evidence
via EPA (Omega-3) · 24 studies, 19 in people
What people often notice when this marker sits outside the usual range
Lower: A low non-HDL is favourable and, unlike calculated LDL-C, stays reliable even when triglycerides are high.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Marine Omega is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Marine Omega pairs with for each. Nothing works in isolation; these share the same systems.
For Foundation Nutrition
For Brain & Sleep
For Women's Health
For Mood & Hormones
Ready-made stacks it is part of
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take the daily serving with a meal that contains some fat to help absorption. If you notice any fishy aftertaste, taking it with food or keeping it refrigerated usually helps.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get Marine OmegaThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Marine Omega delivers high-purity marine omega-3 fatty acids (EPA and DHA) from fish. These are the fats built directly into your cell membranes, the thin outer layer where cells sense the world and pass signals. It is a simple upgrade for the many people whose diets run low on omega-3s.
FAQ
What does Marine Omega support?
It supports healthy cell membrane structure, a healthy inflammation response already within normal range, and normal heart and brain function as part of a balanced diet, while providing EPA and DHA that diets often lack.
How do I take it?
Take the daily serving with a meal that contains some fat to help absorption. If you notice any fishy aftertaste, taking it with food or keeping it refrigerated usually helps.
What makes it different?
It is a marine source tested for purity and freshness, rather than a cheaper oil that can oxidize. Clean, well-sourced omega-3s feed the membrane where signaling and exchange happen.