Ingredient framework; direct source links are available in the studies library when published.
How it works
Adapt -- plant lignans converted by gut bacteria to enterolignans (enterolactone, enterodiol) that weakly bind estrogen receptors and influence estrogen-metabolite balance
Maintain -- contributes to a healthier 2-hydroxyestrone : 16-alpha-hydroxyestrone ratio, with metabolism modified by COMT and CYP1B1 genotype
Exchange -- conversion of secoisolariciresinol to the active enterolignans depends entirely on specific gut bacteria, so an individual's microbiome composition -- not just how much flax lignan is consumed -- determines how much active enterolactone/enterodiol is actually produced
Sense -- enterolignans have a molecular shape similar enough to estradiol to weakly occupy estrogen receptors, allowing them to act as partial agonists/antagonists depending on the body's own estrogen level at the time -- weaker than estradiol when estrogen is high, mildly estrogenic when estrogen is low
Form matters
The same nutrient can be made in very different forms -- and a study done on one form does not automatically apply to another. Methylcobalamin is not cyanocobalamin; magnesium glycinate is not magnesium oxide; a whole-food extract is not the synthetic isolate that was studied. Two things decide whether what is in the bottle behaves like the research: the exact form, and independent lab verification (a Certificate of Analysis) that the form and dose on the label are truly what is inside. Without a COA, you are trusting a label, not the science.
Works well with
The science on Flax lignans
Powered by CellWell.lifeBalanced by design -- we show supporting and contradicting findings. Search all studies