FAT

Phosphatidylserine

Fat -- also: brain phospholipid, ps, Phosphatidylserine

One ingredient, seen the whole way through: what it is, how it works, the honest evidence, the form that matters, the systems it touches, and the studies behind it.

By The Holistic Hub Editorial CollectiveFramework content

Ingredient framework; direct source links are available in the studies library when published.

See noteCell

How it works

  • Exchange -- normally confined to the inner leaflet of the cell membrane; its externalization is a recognized 'eat-me' signal for immune clearance of dying cells

  • Sense -- involved in cell-surface signaling complexes, including neuronal synaptic membranes

  • Regulate -- randomized human trials show phosphatidylserine supplementation can blunt the cortisol spike from acute exercise or psychological stress

  • Maintain -- concentrated in neuronal membranes, proposed (though not firmly established) to support synaptic membrane integrity with aging

Form matters

The same nutrient can be made in very different forms -- and a study done on one form does not automatically apply to another. Methylcobalamin is not cyanocobalamin; magnesium glycinate is not magnesium oxide; a whole-food extract is not the synthetic isolate that was studied. Two things decide whether what is in the bottle behaves like the research: the exact form, and independent lab verification (a Certificate of Analysis) that the form and dose on the label are truly what is inside. Without a COA, you are trusting a label, not the science.

The science on Phosphatidylserine

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Balanced by design -- we show supporting and contradicting findings. Search all studies