Encephalon

A review describes how circular RNAs, non-coding RNA loops formed by back-splicing, regulate transcription, translation, and stress responses in microalgae and other eukaryotic cells.

Dehghani J; Panahi B; Nolsøe JMJ; Lerouge P; Bardor M; Omidi Y -- Biotechnology advances

In the marine diatom Phaeodactylum tricornutum, exposure to the pollutant diethylstilbestrol reduced chlorophyll content and photosynthetic efficiency while triggering increased antioxidant enzyme activity such as superoxide dismutase and catalase.

Zhao DS; Liu XL; Chen YT; Yang H; Farooq MA; Yan X; Zou HX -- Aquatic toxicology (Amsterdam, Netherlands)

Using heavy-ion beam irradiation, researchers created fucoxanthin-deficient microalgae strains that instead accumulated biosynthetic intermediates haptoxanthin and phaneroxanthin, helping clarify the fucoxanthin production pathway.

Kubo S; Sano T; Kawachi M; Hase Y; Satoh K; Oono Y; Iwata Y; Endo H; Araie H; Yoneda K; Maeda Y; Suzuki I -- Plant & cell physiology

Low-voltage alternating electric fields repelled marine biofouling microalgae with 97.2% efficiency, working by raising intracellular reactive oxygen species and lipid peroxidation in the algal cells.

Zhou Z; Huang X; Sun D; Yu H; Jiang X -- Bioelectrochemistry (Amsterdam, Netherlands)

Exposure to the pharmaceutical contaminant diclofenac caused mild physiological effects but altered gene expression and increased nutrient and energy demands in the marine diatom Phaeodactylum tricornutum.

Alezra L; Le Floc'h E; Félix C; Rosain D; Gomez E; Courant F; Fouilland E; Cheloni G -- Environmental pollution (Barking, Essex : 1987)

Phaeodactylum tricornutum is being developed as a photosynthetic microbial chassis for sustainable bioproduction of high-value compounds including fucoxanthin and EPA, supported by genetic and non-genetic engineering toolkits.

Wang S; Hao Y; Qiao T; Zhang R; Yu D; Wang H; Liu Y; Sun Y; Xu D; Song X; Pan K -- Marine drugs

Intermittent light-dark cycles increased growth, photosynthetic efficiency, and pigment production in the diatom Phaeodactylum tricornutum, upregulating chlorophyll and carotenoid biosynthesis genes under short light intervals.

Zheng J; Yuan J; Wang X; Zhang D; Lin L; Shi N; Feng Y -- Microbiology spectrum

The marine microalga Phaeodactylum tricornutum biodegraded 88.4 percent of tetracycline in solution through cytochrome P450 demethylation and deamination, metallo-beta-lactamase bond cleavage, and FAD-dependent monooxygenase oxygenation pathways.

Wu X; Chen J; Du H; Ye Z; Zhang S; Bao R; Xu Y; Meador JP; Zhang Q; Wang S; Wang Z; Liu X -- Bioresource technology

Alginate-derived oligosaccharides expanded the temperature tolerance range of Phaeodactylum tricornutum by 3.4 degrees C, increased biomass by 50 percent at 24 degrees C, and boosted fucoxanthin yield by 46 percent and EPA levels by 72 percent.

Che X; Fan D; Ding R; Zhang L; Zhu B; Li Y -- Bioresource technology

Multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine improved sprint performance, visual reaction time, and perceived mental fatigue in professional football players.

Krzysztof Mizera; Dominik Mazurek; Alejandro Martínez-Rodríguez; Anna Kęska

In humans, Mental health is threatened every day by the stressors of life: frenetic work rhythms, stressful conditions can generate anxiety, depression, cognition, and sleep problems

Kenny Hawkins; Justine Davis; Cristal Abreu Matias; Gabriel Wilson; Ryan Lowery; Paola Misiano; Giovanna Petrangolini; Jacob Wilson

Among 81 professional male footballers in three groups of 27, taurine with caffeine and phosphatidylserine raised locomotor performance and reduced fatigue-related sprint decline to 18 percent against 34 percent on placebo.

Krzysztof Mizera; Elżbieta Mizgała-Izworska; Justyna Mizera; Jan Mackiewicz

Dysregulated lipid metabolism and adverse lipid profiles are associated with late-life depression through peripheral inflammation and altered brain phospholipid metabolism, though omega-3 evidence remains inconsistent.

Yao Gao; Han-Ni Li; Ze-Kun Li; Jian-Zhen Hu; Xin-Zhe Du; Xin Yan; Sha Liu

A combined Bacopa, phosphatidylserine, and choline formulation attenuated stress-induced neuroinflammation and neurotoxicity in microglial and neuronal cell models.

Chiara Sasia; Giacomina Videtta; Nicoletta Galeotti -- Biomedicines

A review found that L-serine, a precursor of phosphatidylserine, supports one-carbon metabolism, glutathione and heme synthesis, and neurotransmission pathways linked to synaptic plasticity and cognitive function.

Kustrimovic N; Rabattoni V; Riva D; Motta Z; Sacchi S; Pollegioni L -- Molecular aspects of medicine

In human red blood cells, polyphenol-rich tomato extracts protected against mercury-induced damage, preserving membrane phospholipid asymmetry and reducing the procoagulant phenotype from oxidative stress.

Claudia Moriello; Nicola Alessio; Rosario Finamore; Chiara De Rosa; Chiara Schiraldi; Caterina Manna; Stefania D'Angelo; Pasquale Perrone

In human neuroblastoma cells, the fungicide trifloxystrobin induced mitochondrial dysfunction and apoptosis, marked by phosphatidylserine exposure, through activation of the OMA1-DELE1-HRI integrated stress response pathway.

Chaabani H; Ayed I; Rjiba K; Abid S; Eyer J; Arnoult D -- Environmental pollution (Barking, Essex : 1987)

Neuraminidase-induced ADAM17 activation shed glypican-1 through ANO6 scramblase externalisation of phosphatidylserine, proposed as a mechanism of impaired endothelial glycocalyx function.

Augenreich MA; Ferreira-Santos L; Power G; Ramirez-Perez FI; Gonzalez-Vallejo JD; Williams MB; Imkaew N; Cho MJ; Wheeler AA; Manrique-Acevedo C; Martinez-Lemus LA; Padilla J -- American journal of physiology. Cell physiology

In a myocardial infarction model, a nanodecoy using arginine-modified phosphatidylserine lipids and platelet membrane targeting delivered an immunosuppressive oligonucleotide to cardiac macrophages, suppressing cGAS-STING signaling and pro-inflammatory cytokines.

Wang P; Li R; Ni J; Li D; Ting MH; Ma K; Fu G; Ge J; Zhao S; Zhang W; Zhang N; Liu X -- Journal of controlled release : official journal of the Controlled Release Society

In models of alcohol-related liver disease, liver sinusoidal endothelial cells took up oxidatively damaged red blood cells, and ethanol primed red cells for clearance by exposing phosphatidylserine.

Siyuan Li; Chaowen Zheng; Xiaowei Zha; Johannes Mueller; Anne Dropmann; Seddik Hammad; Steven Dooley; Sebastian Mueller

Phosphatidylserine externalization, normally a transient apoptotic signal, becomes chronically dysregulated on cancer cell and tumor-vessel surfaces, creating an immunosuppressive interface implicated in tumor immune evasion.

Yoo M; Kim KH -- International journal of molecular sciences

Haloperidol showed antifungal activity, alone and combined with conventional antifungals, against both fluconazole-susceptible and fluconazole-resistant Candida strains, representing a drug-repurposing approach to candidiasis.

Carvalho de Oliveira L; de Almeida Moreira LE; Pessoa Farias Cabral V; Sampaio Rodrigues D; Castelo Branco Silveira MJ; Lima Ferreira T; Medeiros de Oliveira AC; Coêlho Cavalcanti B; Lima Magalhães I; de Oliveira Ferreira JR; de Moares Filho MO; de Andrade Neto JB; Gurgel do Amaral Valente Sá L; Nobre Júnior HV; Rocha da Silva C -- Microbial pathogenesis

Over one year of aging, semen quality in Oravka roosters declined with reduced sperm motility, membrane and acrosome integrity, and increased phosphatidylserine externalization alongside other oxidative and immune changes.

Tvrdá E; Benko F; Ďuračka M; Kováčik A; Jančo I; Árvay J; Kačániová M; Vozaf J; Baláži A; Chrenek P -- Poultry science

Review describes how cancer-associated metabolic reprogramming, including changes in energy metabolism, redox balance, and calcium signaling, alters flippase and scramblase activity, externalizing phosphatidylserine on the outer cell membrane.

Kim KH; Yoo BC -- International journal of molecular sciences