Encephalon

In genetically engineered Alzheimer's model mice, a concentrated Ginkgo biloba extract called YY-1224 reduced amyloid-induced memory impairment and brain inflammation markers, but this effect required a working COX-2 gene to occur.

Li ZY; Chung YH; Shin EJ; Dang DK; Jeong JH; Ko SK — Journal of neuroinflammation

A review of phosphatidylserine, a lipid component of HDL particles, describes correlations between its amount in HDL and lab measures of HDL function, without presenting new patient outcome data.

Darabi M; Kontush A — Biochimie

A review of fucoxanthin, a pigment from edible brown seaweed, summarizes laboratory findings on obesity, tumor, diabetes and antioxidant related activity, but reports no original clinical trial results in humans.

Zhang H; Tang Y; Zhang Y; Zhang S; Qu J; Wang X — Evidence-based complementary and alternative medicine : eCAM

In cultured PC12 nerve cells exposed to ethanol, the compound ginkgolide B reduced cell death, oxidative damage and NADPH oxidase activity, but did not change ethanol-metabolizing enzyme activity in the cells.

Zhang C; Tian X; Luo Y; Meng X — Toxicology

In mice deprived of sleep for 72 hours, hippocampal markers of oxidative damage rose alongside memory loss, and both effects were blocked by prior treatment with the antioxidants melatonin, PBN or vitamin E.

Silva RH; Abílio VC; Takatsu AL; Kameda SR; Grassl C; Chehin AB — Neuropharmacology

Using heavy-ion beam irradiation, researchers created fucoxanthin-deficient microalgae strains that instead accumulated biosynthetic intermediates haptoxanthin and phaneroxanthin, helping clarify the fucoxanthin production pathway.

Kubo S; Sano T; Kawachi M; Hase Y; Satoh K; Oono Y; Iwata Y; Endo H; Araie H; Yoneda K; Maeda Y; Suzuki I — Plant & cell physiology

A review describes how circular RNAs, non-coding RNA loops formed by back-splicing, regulate transcription, translation, and stress responses in microalgae and other eukaryotic cells.

Dehghani J; Panahi B; Nolsøe JMJ; Lerouge P; Bardor M; Omidi Y — Biotechnology advances

Alginate-derived oligosaccharides expanded the temperature tolerance range of Phaeodactylum tricornutum by 3.4 degrees C, increased biomass by 50 percent at 24 degrees C, and boosted fucoxanthin yield by 46 percent and EPA levels by 72 percent.

Che X; Fan D; Ding R; Zhang L; Zhu B; Li Y — Bioresource technology

Exposure to the pharmaceutical contaminant diclofenac caused mild physiological effects but altered gene expression and increased nutrient and energy demands in the marine diatom Phaeodactylum tricornutum.

Alezra L; Le Floc'h E; Félix C; Rosain D; Gomez E; Courant F; Fouilland E; Cheloni G — Environmental pollution (Barking, Essex : 1987)

The marine microalga Phaeodactylum tricornutum biodegraded 88.4 percent of tetracycline in solution through cytochrome P450 demethylation and deamination, metallo-beta-lactamase bond cleavage, and FAD-dependent monooxygenase oxygenation pathways.

Wu X; Chen J; Du H; Ye Z; Zhang S; Bao R; Xu Y; Meador JP; Zhang Q; Wang S; Wang Z; Liu X — Bioresource technology

Low-voltage alternating electric fields repelled marine biofouling microalgae with 97.2% efficiency, working by raising intracellular reactive oxygen species and lipid peroxidation in the algal cells.

Zhou Z; Huang X; Sun D; Yu H; Jiang X — Bioelectrochemistry (Amsterdam, Netherlands)

Phaeodactylum tricornutum is being developed as a photosynthetic microbial chassis for sustainable bioproduction of high-value compounds including fucoxanthin and EPA, supported by genetic and non-genetic engineering toolkits.

Wang S; Hao Y; Qiao T; Zhang R; Yu D; Wang H; Liu Y; Sun Y; Xu D; Song X; Pan K — Marine drugs

In the marine diatom Phaeodactylum tricornutum, exposure to the pollutant diethylstilbestrol reduced chlorophyll content and photosynthetic efficiency while triggering increased antioxidant enzyme activity such as superoxide dismutase and catalase.

Zhao DS; Liu XL; Chen YT; Yang H; Farooq MA; Yan X; Zou HX — Aquatic toxicology (Amsterdam, Netherlands)

Intermittent light-dark cycles increased growth, photosynthetic efficiency, and pigment production in the diatom Phaeodactylum tricornutum, upregulating chlorophyll and carotenoid biosynthesis genes under short light intervals.

Zheng J; Yuan J; Wang X; Zhang D; Lin L; Shi N; Feng Y — Microbiology spectrum

The marine diatom Phaeodactylum tricornutum is being engineered as a production platform for fucoxanthin and other bioactive compounds using CRISPR and other genetic tools, advancing sustainable ingredient sourcing.

Wang S; Hu Z — Plant communications

Study of the marine diatom Phaeodactylum tricornutum found propranolol's R-enantiomer caused oxidative damage and energy metabolism disruption while the S-enantiomer did not, highlighting the importance of testing individual drug enantiomers in ecotoxicology assessments.

Arenas M; Feijão E; Duarte IA; Fonseca VF; Aparicio I; Alonso E; Duarte B — Marine pollution bulletin

In UV-exposed mouse skin and H2O2-stimulated skin cells, extracellular vesicles derived from the microalga Phaeodactylum tricornutum were nontoxic and taken up by cells, showing potential for protecting skin from oxidative damage.

Xu R; Lu Y; Cai L; Zhang L — ACS biomaterials science & engineering

Using an orthogonal design, researchers found that glycine supplementation combined with specific light intensity significantly increased fucoxanthin accumulation in the microalga Phaeodactylum tricornutum, with underlying gene regulation mechanisms explored.

Yang H; Gong Y; Liu B; Chen Y; Qin H; Wang H; Liu H — Marine drugs

In the diatom Phaeodactylum tricornutum, increasing UV radiation dose reduced growth and photosynthetic pigment levels including fucoxanthin, while triggering xanthophyll-cycle gene expression changes as part of a cellular photoprotection response.

Cella H; Bonomi-Barufi J; Velasquez Bastolla CL; Nader C; Oliveira CY; Lopes RG; Mattos JJ; Horta Junior PA; Venâncio HC; de Oliveira Rodrigues ER; Maraschin M; Rörig LR; Dias Bainy AC; Marques MRF; Derner RB — Photosynthesis research

Metabolomic and computational analysis of the microalga Phaeodactylum tricornutum identified metabolic pathways, including glyoxylate and dicarboxylate metabolism, that could be optimized to boost fucoxanthin and EPA biosynthesis.

Schmitz C; Sforca ML; Maraschin M — Applied biochemistry and biotechnology

In microalgae exposed to the antioxidant contaminant BHT, growth and pigment production were inhibited while antioxidant enzyme activity rose, and the microalgae's secretion of IAA promoted growth of a BHT-tolerant bacterium in its surrounding microbiome.

Lu X; Liu J; Xiao X; Xue J; Cheng D; Zhang L — World journal of microbiology & biotechnology

Researchers achieved the first heterologous production of the carotenoid neoxanthin in Saccharomyces cerevisiae yeast by engineering the beta-carotene and violaxanthin biosynthesis pathways along with a gene from a marine microalga.

Arenas N; Cataldo VF; Agosin E — Microbial cell factories

In a mouse model of carbon tetrachloride-induced liver fibrosis, fucoxanthin, a marine carotenoid from brown algae, improved liver function and reduced fibrosis and inflammation markers via the Nrf2/HO-1/GPX4 ferroptosis pathway.

Liu Z; Ye J; Xi J; Li Q; Tang Y; Tian Y; Wang D; Yang Z; Ding Y — Food science & nutrition

In the marine diatom Phaeodactylum tricornutum, methyl jasmonic acid treatment triggered RNA editing that regulated fucoxanthin and fatty acid metabolism, offering a strategy to boost production of these commercially valuable bioactive compounds.

Huang S; Liu H; Xu R; Li W; Yang H; Bao X; Hang Y; Gong Y; Zhao Y — Marine drugs