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What it is
A vitamin K supplement carrying the whole family -- K1 plus K2 in both its MK-4 and MK-7 forms. Vitamin K is the cofactor the body uses to activate proteins like osteocalcin and matrix-Gla protein, the ones that direct calcium toward bone and away from soft tissue. Carrying all three forms covers both the fast-clearing (K1, MK-4) and the long-circulating (MK-7) members of the family.
Why the evidence supports it
Vitamin K's job is specific and well characterized: it switches on the calcium-handling proteins, and controlled trials of MK-7 show it measurably increases the active, carboxylated form of those proteins over months of use. That mechanism is why the full K family is favored over a single fraction -- the forms clear at different rates and reach different tissues. Full circle, this is the cell's Build function: activating the proteins that guide calcium into the bone matrix rather than soft tissue. One real caution -- vitamin K interacts with blood thinners, so anyone on those needs a doctor's sign-off first.
What it supports
- Supports the body's normal handling of calcium toward bone
- Supports healthy bone metabolism
- Works alongside vitamin D and calcium
- Provides the full K family (K1, MK-4, MK-7)
Which function it supports
Ties to the cell's Build function -- vitamin K activates the proteins that guide calcium into bone rather than soft tissue.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (2 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision label image on the product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 1 veg capsule | Amount | % DV |
|---|---|---|
| Vitamin K1as Phytomenadione | 1000 mcg | 833% |
| Vitamin K2as MK-4 (Menaquinone-4) | 2000 mcg | ** |
| Vitamin K2as MK-7 (Menaquinone-7), from Bacillus licheniformis extract MenaQ7 | 400 mcg | ** |
- Servings per container:
- 30
- Other ingredients:
- Vegetarian capsule (hypromellose and water), bamboo extract.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysisPubMed
2025
Vitamin K2 supplementation increased osteocalcin and decreased undercarboxylated osteocalcin and bone resorption markers in postmenopausal osteoporosis patients.
- Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic reviewPubMed
Journal of bone and mineral metabolism · 2022
In a meta-analysis of nine randomized trials in postmenopausal women with osteoporosis, vitamin K2 supplementation was associated with increased lumbar and forearm bone mineral density, with more adverse reactions but no serious adverse events.
- Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: systematic review and meta-analysis of RCTsSource
Frontiers in Public Health · 2022
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: systematic review and meta-analysis of RCTs, Frontiers in Public Health, 2022
- Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal OsteoporosisPubMed
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2025
In 77 women with postmenopausal osteoporosis randomized to vitamin K2 alone or with rhPTH(1-34), the combination improved bone mineral density and bone metabolism markers more, without more adverse reactions.
- Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trialPubMed
Atherosclerosis · 2025
In 388 men aged 65-74 over 24 months, daily vitamin K2 (720 µg) and D3 (25 µg) significantly lowered markers of vitamin K deficiency but showed no effect on epicardial adipose tissue or systemic inflammation.
- Vitamin K2 in Managing Nocturnal Leg Cramps: A Randomized Clinical TrialPubMed
JAMA internal medicine · 2024
Vitamin K2 (menaquinone-7) 180 µg daily for 8 weeks reduced nocturnal leg cramp frequency, severity and duration versus placebo in community-dwelling adults aged 65 and older in a randomized trial.
Beyond Bone Health: Exploring the "Heart-Brain-Bone" Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)EmergingExpert review2026
This narrative review found that cardiovascular, cognitive, and bone benefits of combined omega-3, vitamin D3, and vitamin K2 remain clinically unproven, with no adequately powered trial showing the combination outperforms its individual components.
Shih-Chin Fang; Meng-Kai Huang; Hsieh-Tsung Ethan Shen; Bo-Xiang Benjamin Zhang; Ting-Hsuan Collette Chao; Chung-Che Wu
Gut dysbiosis and vitamin-dependent immune regulation in degenerative musculoskeletal and bone diseasesEmergingExpert review2026
Dysbiosis may promote degenerative bone diseases through altered vitamin D-menaquinone signaling and pro-inflammatory immune activation affecting bone remodeling.
Nicola Stefanelli
Sex-Specific Effects of Menaquinone-7 (MK-7) Supplementation on Body Composition and Adiposity MarkersEmergingPrimary research (design unspecified)2026
In 243 adults with low vitamin K status over 1 year, menaquinone-7 supplementation (180 mcg/day) produced modest BMI reduction (-0.66%) and fat mass decreases, with significantly greater improvements in women than men.
Bittner R; de Vries F; Machuron F; Maresz K; Gåserød O; Schurgers L -- Nutrients
Integrative approaches to perimenopause.2026
A review of perimenopause found that supplements including calcium, vitamin D, magnesium, and vitamin K2 are used to support bone health, alongside lifestyle and hormone-based approaches for symptom management.
Kennard A; Saunders KT -- The American journal of medicine
Development and application of a simple, high-throughput magnetic bead-assisted liquid chromatography-tandem mass spectrometry method for the quantification of vitamin K1 and vitamin K2 (menaquinone-4 and menaquinone-7) in human serumEmergingPreprint2026
A novel high-throughput magnetic bead LC-MS/MS method quantified vitamin K1, MK-4, and MK-7 in human serum with linear ranges 0.2--10 ng/mL and coefficients of variation 2--4% in 245 healthy volunteers.
Yinglan Zhu; Yu Zhou; Jing Du; Yanan Wang; Lingli Yan; Yangxiao Zhou; Jun Xia
Menaquinone depletion resensitises bedaquiline-resistant tuberculosis.2026
In drug-resistant tuberculosis models, inhibiting MenG, an enzyme in the bacterial menaquinone biosynthesis pathway, restored bacterial susceptibility to bedaquiline, achieving a 99.8% reduction in bacterial burden when combined.
Wetzel J; Dallow J; Davis E; Pearson WH; Daems S; Govaerts M; Hereijgers J; Sprangers J; Truebody B; Maes V; van Hasselt V; Leemans A; Pujari V; Vos A; Viturro CMM; Gómez JE; Peeters M; Gerber M; Chhabra N; Wouters A; Everaerts M; Painter H; Fathima R; Willcocks SJ; Davies C; Raeymaekers V; Clark TG; Draghia-Akli R; Fletcher H; Van Loock M; Hibberd ML; Mostowy S; Crick DC; Pym AS; Samby K; Jackson P; Trabanco AA; Larrouy-Maumus G; Steyn AJC; Stoops B; Dhar N; Aguilar-Pérez C; Lamprecht DA; Wall RJ; Koul A -- bioRxiv : the preprint server for biology
2-Pentadecyl-2-oxazoline alleviates anxiety-like behaviour and modulates the microbiota-gut-brain axis in obese miceEmergingPrimary research (design unspecified)2026
In high-fat diet-induced obese mice, the compound 2-pentadecyl-2-oxazoline reduced anxiety-like behavior and hippocampal neuroinflammation without changing body weight, while enriching butyrate- and menaquinone-producing gut bacteria.
Nicola Opallo; Adriano Lama; Stefania Melini; Lorena Coretti; Federica Comella; Filomena Del Piano; Nicole Pia Navatti; Alessia D'Andrea; Carmen De Caro; Francesca Lembo; Maria Carmela Ferrante; Rosaria Meli; Giuseppina Mattace Raso; Claudio Pirozzi
Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.2026
In C. elegans, low-dose vitamin K2 at 5 micromolar extended lifespan and improved stress resistance by maintaining mitochondrial morphology through the JNK-1/SIR-2.1/DAF-16 signaling axis, while higher doses were toxic.
Guo SY; Li YQ; Piao H; Zheng WF; Li SQ; Liu ZY; Lv JT; Kong Y; Li QF; Wang YZ; Li SZ; Zhao CL; Li S -- Aging cell
Vitamin K2 Supplementation Reduces Cardiometabolic Risk Factors in Young Adults with Overweight and Obesity-A Randomized Placebo-Controlled TrialEmergingPrimary research (design unspecified)2026
In a randomized placebo-controlled trial, 12 weeks of vitamin K2 supplementation lowered total and LDL cholesterol in young adults with overweight or obesity, without affecting body composition or glucose metabolism.
Xochitl Citlalli Olivares-Ochoa; Iris Monserrat Llamas-Covarrubias; Sergio Sánchez-Enríquez; Andres López-Quintero; Yahatziri Salinas-Varela; Miriam Partida-Pérez; Monserrat Macías-Carballo; Edgar Alfonso Rivera-Leon
Vitamin K2 and D3 Supplementation in Patients With Severe Coronary Artery Calcification: The DANCODE TrialEmergingPrimary research (design unspecified)2026
In the DANCODE trial of 398 patients with severe coronary artery calcification, 24 months of vitamin K2 plus D3 supplementation reduced coronary calcium score progression versus placebo, without increasing noncalcified plaque volume.
Hasific S; Øvrehus KA; Mejldal A; Hosbond S; Lambrechtsen J; Kumarathurai P; Dey D; Ravn EJ; Rasmussen LM; Gerke O; Mickley H; Diederichsen A -- Circulation
VKORC1L1-mediated vitamin K recycling counters ferroptosis to promote endothelial repairEmergingPrimary research (design unspecified)2026
In human coronary endothelial cells and mice, menaquinone-7 reduced ferroptosis and inflammation and accelerated vessel repair after injury, effects that depended on the enzyme VKORC1L1 rather than coagulation-linked VKORC1.
Elena Repges; Adem Aksoy; Katrin J Czogalla-Nitsche; Andreas Zietzer; Cornelius Müller; Johannes Oldenburg; Sebastian Zimmer; Georg Nickenig; Vedat Tiyerili; Muntadher Al Zaidi
High-level production of vitamin K2 in Escherichia coli via modular molecular engineeringEmergingPrimary research (design unspecified)2026
Using modular metabolic engineering and enzyme mutation of EcMenA in Escherichia coli, researchers boosted menaquinone-7 (vitamin K2) production to a maximum titer of 2.18 g/L in bioreactor fermentation.
Zelin Lu; Zhongshi Huang; Zhengyin Wu; Zhengwen Zhu; Yibo Zhu; Xiaonuo Teng; Huyang Chen; Jingwen Zhou; Fuqiang Ma; Xinglong Wang
Quantitative analysis of phylloquinone (vitamin K1) and menaquinone (vitamin K2) in serum of Russians by liquid chromatography-tandem mass spectrometryEmergingPrimary research (design unspecified)2026
A validated HPLC-MS/MS method measured vitamin K1 and MK-4 in serum from 20 healthy Russian adults, detecting K1 in only four individuals and MK-4 below 0.22 μg/L in all samples.
Mikhail Vokuev; Anastasia Frolova; Stepan Makarkin; Daria Prosuntsova; Timur Baygildiev; Lidia Nefedova; Oleg Klychnikov; Igor Rodin -- Clinical Chemistry and Laboratory Medicine (CCLM)
Menaquinone-7 in Atherosclerosis: Integrated Modulation of Endothelial Dysfunction, Oxidative Stress, and Vascular InflammationEmergingPrimary research (design unspecified)2026
This review describes how menaquinone-7 may reduce vascular calcification via matrix Gla protein activation while also modulating endothelial function, oxidative stress, and inflammation, though direct human vascular evidence remains limited.
Hayat Hassen; Tomasz Tarko; Magdalena Franczyk-Żarów -- Applied Sciences
Vitamin K and vascular calcification: from biological plausibility to clinical realismEmergingPrimary research (design unspecified)2026
This review found that vitamin K1 showed more consistent, though still mixed, evidence for slowing calcification progression in chronic kidney disease than vitamin K2, with neither reducing cardiovascular events or mortality.
Vincent Brandenburg; Hermann Salmhofer; Turgay Saritas; Thilo Krüger; Nikolaus Keil -- Oxford University Press (OUP)
Associations between dietary vitamin K1 and K2 intake and incident dementia: findings from the Danish Diet, Cancer, and Health cohortEmergingPrimary research (design unspecified)2026
Higher dietary vitamin K1 intake was associated with lower dementia risk, whereas higher vitamin K2 intake was associated with higher risk.
Negar Ghasemifard; Marc Sim; Pratik Pokharel; Chengfeng Li; Allan Linneberg; Anne Ahrendt Bjerregaard; Anja Olsen; Christina C Dahm; Simone Radavelli-Bagatini; Simon M Laws; Joshua R Lewis; Jonathan M Hodgson; Nicola P Bondonno
Molar incisor hypomineralisation in relation to fat-soluble vitamin status and intestinal permeability in children with celiac diseaseEmergingPrimary research (design unspecified)2026
In a pilot case-control study of children with celiac disease, molar-incisor hypomineralization occurred in 77% of affected children and was linked to lower serum vitamin K2 and vitamin D levels.
Lucian-Ioan Cristun; Raluca-Nicoleta Vasilescu; Niculina Mang; Iulius Jugănaru; Otilia Mărginean; Andrei-Ioan Munteanu; Delia-Maria Nicoară; Andrei Păun; Alexandra-Diana Cheleș; Laura Cristina Rusu
Beneficial Effects of Purified Cytoplasm of Pollen Associated with Vitamin D and Vitamin K2 on Menopausal Symptoms and Bone HealthEmergingPrimary research (design unspecified)2026
In a retrospective study of 22 symptomatic menopausal women, three months of a pollen cytoplasm, vitamin D and vitamin K2 combination was associated with lower serum CTX and better quality-of-life scores than in 23 untreated controls.
Anna Capozzi; Anna Fagotti; Davide Sacco; Anna Pasi; Rossella Mellino; Stefano Lello
Unusually High Enrichment of Bioactive Components for Healthy Aging and Longevity in Natto, a Fermented Soybean FoodEmergingPreprint2026
A 50g serving of natto provides 429% of effective vitamin K2 dose, 200% probiotic dose, 625% spermidine, and 73% isoflavone by clinical trial measures.
Shin Murakami
Differences in Nutrition and Sensory Quality Between Cooked Soybeans, Fermented Natto, and Post-Ripening NattoEmergingPrimary research (design unspecified)2026
Natto fermentation increased water-soluble protein, free amino acids, vitamin K2, nattokinase activity, and bioavailable isoflavones while reducing fat and sugars.
Yuguang He; Yuanyuan Jiang; Da Li; Xue Ou; Xinyu Miao; Mubai Sun; Honghong Niu; Mei Hua; Ying Su; Jinghui Wang; Zhuo Liu
Effects of Menaquinone-7 on Bone Turnover Markers, Femoral Mechanical Resistance, and Histology in Young Ovariectomized RatsEmergingPrimary research (design unspecified)2026
High-dose menaquinone-7 improved femoral mechanical resistance in ovariectomized rats and reduced undercarboxylated osteocalcin, indicating vitamin K-dependent bone engagement.
Alexandru Jecan; Gheorghe Tomoaia; Luciana-Mădălina Gherman; Vasile Rus; Raluca Maria Pop; Cătălin Popa; Răzvan Marian Melinte; Diana Jecan-Toader; Dragoș Apostu; Luca Simionescu; Vlad Blănaru; Daniel Oltean-Dan
Fermentation regulation and identification of short-chain and long-chain menaquinones (vitamin K2) from Elizabethkingia meningosepticaEmergingPrimary research (design unspecified)2026
Elizabethkingia meningoseptica achieved maximum menaquinone yields at pH 8 and 32°C, with one strain synthesizing four different MK congeners simultaneously.
Hongfei Wei; Liping You; Tianjiao Shen; Jiamei Gao; Xiao-Dan Liang; Honghan Zhao; Jingru Sun; Zhiping Wu; Xiaohong Li; Chengshi Ding
Gene III® L-Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized miceEmergingPreprint2026
Ergothioneine combined with vitamin K2, D3, and magnesium L-threonate preserved trabecular bone area and lowered oxidative and inflammatory markers in ovariectomized mice.
Wei Liu; Yongxian Tang; Wei Ding; Juan Cao; Cong Guo; Guohua Xiao
Enhanced Osteogenic Differentiation of Primary Human Osteoporotic Osteoblasts on a Roughened Titanium Surface by Vitamin K2 and Vitamin D3 Compared to the Differentiation Behaviour of Primary Healthy Human OsteoblastsEmergingPrimary research (design unspecified)2026
In cultured osteoporotic osteoblasts, vitamin K2 more strongly enhanced mineralization on roughened titanium than vitamin D3 alone, suggesting K2 has a greater metabolic role than previously recognized.
Katharina Tscheu; Katharina Schultz; Christoph V Suschek; Uwe Maus
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Vitamin D (25-Hydroxyvitamin D)emerging evidence
via Vitamin K · 10 studies, 6 in people
Directs the calcium that vitamin D makes available into bone rather than soft tissue.
What people often notice when this marker sits outside the usual range
Higher: Excess comes from supplements, essentially never from sun.
Lower: Fatigue -- our library holds an explicit study of 25(OH)D and fatigue severity in adults.
- Bone Health: DEXA / T-score, CTX, P1NPemerging evidence
via Vitamin K · 4 studies, 2 in people
Carboxylates osteocalcin, which is a plausible and specific mechanism.
What people often notice when this marker sits outside the usual range
Higher: A high T-score is favourable; very high values occasionally reflect degenerative change in the spine artificially inflating the reading.
Lower: Bone loss is SILENT until a fracture.
- Vitamin D, Calcium, and Parathyroid Hormone (PTH)emerging evidence
via Vitamin K · 4 studies, 2 in people
Carboxylates osteocalcin and matrix Gla protein -- a specific, plausible mechanism.
What people often notice when this marker sits outside the usual range
Lower: CALCIUM LOW: tingling around the mouth and in fingers, muscle cramps and twitching, irritability.
- Calciumemerging evidence
via Vitamin K · 1 studies, 0 in people
Carboxylates osteocalcin and matrix Gla protein -- the proteins that put calcium into bone and keep it out of arteries.
What people often notice when this marker sits outside the usual range
Higher: "Bones, stones, groans and psychic moans" -- the old teaching phrase, and still the best summary: bone pain, kidney stones, abdominal pain and constipation, low mood and confusion.
Lower: Tingling around the mouth and in the fingers and toes.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Purely-K is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Purely-K pairs with for each. Nothing works in isolation; these share the same systems.
For Bone & Cartilage
For Foundation Nutrition
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take with a meal that contains some fat, since vitamin K is fat-soluble. It pairs naturally with vitamin D at the same meal. If you take a blood thinner such as warfarin, do not start this without your doctor's guidance. Follow the label.
Use code HOLISTICLOVE at checkout.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get Purely-KThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Purely-K carries the whole vitamin K family -- K1 plus K2 in both MK-4 and MK-7 forms. Vitamin K is part of how the body activates the proteins that direct calcium where it belongs, toward bone. It fits people who want the full K family working alongside their vitamin D and calcium.
FAQ
What does Purely-K support?
It supports the body's normal handling of calcium toward bone and healthy bone metabolism, works alongside vitamin D and calcium, and provides the full K family (K1, MK-4, MK-7).
How do I take it?
Take with a meal that contains some fat, since vitamin K is fat-soluble. It pairs naturally with vitamin D at the same meal. If you take a blood thinner such as warfarin, do not start this without your doctor's guidance.
What makes it different?
It carries the full K family rather than a single fraction. Vitamin K is a quiet nutrient that works alongside vitamin D and calcium, and most people rarely think about it.