$60.00
Your discount applies with code HOLISTICLOVE.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
A blend of proteolytic (protein-digesting) enzymes taken between meals rather than with food, so they act systemically instead of on a meal. Used this way, proteolytic enzymes support the body's normal, everyday breakdown and clearing processes.
Why the evidence supports it
Proteolytic enzymes have a real but still-developing research base for supporting a normal inflammation response and the body's routine clearing work when taken away from food -- an honest 'growing evidence' tier rather than a settled one. The rationale is mechanistic: unoccupied by a meal, these enzymes stay available to the body's own housekeeping. So the claim stays modest -- this serves the cell's Maintain function, the ordinary daily upkeep, not a cleanse that fixes anything. Taken away from meals with plenty of water is how it is meant to be used.
What it supports
- Supports the body's normal breakdown and clearing processes
- Provides proteolytic enzymes taken between meals
- Supports a healthy inflammation response already within normal range
- Complements good hydration and a balanced routine
Which function it supports
Ties to the cell's Maintain function -- supporting the body's normal daily upkeep. What people use it for is a matter of preference, not a proven medical outcome.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (1 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision label image on the product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 1 capsule | Amount | % DV |
|---|---|---|
| Systemic Enzyme Blend | 500 mg | * |
| Serrapeptase | 80,000 u | |
| Nattokinase | 2,000 FU | |
| Bromelain | 15 GDU | |
| Papain | 5 TU | |
| Lipase | 1,000 FIP | |
| Protease Alkaline | 40,500 PC | |
| Protease Fungal | 5,000 HUT | |
| Rutin | 25 mg | |
| Amla | 25 mg |
- Servings per container:
- 90
- Other ingredients:
- Vegetarian capsule (hypromellose and water), bamboo extract.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- A Randomized, Placebo-controlled Trial of Digestive Enzymes in Children with Autism Spectrum DisordersPMC
Clinical Psychopharmacology and Neuroscience · 2015
In a small randomized placebo-controlled trial, a digestive-enzyme supplement was associated with improvements in some gastrointestinal and behavioral measures; single small RCT, structure/function support for digestion.
- A Randomized, Placebo-controlled Trial of Digestive Enzymes in Children with Autism Spectrum Disorders.PubMed
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2015
In a 3 month trial of 101 children with autism spectrum disorder, those given digestive enzymes showed more improvement in behavior, emotional response and gut symptoms than those given placebo.
- Evaluation of different stocking densities on growth parameters, digestive enzymes, hemato-immunological and stress responses of Cirrhinus reba (Hamilton, 1822)DOI
Aquaculture Science and Management · 2026
Lower stocking density (10 fish/m³) in Cirrhinus reba improved growth, enzyme activity, and reduced plasma glucose and cortisol compared to higher densities.
- Effects of different levels of curcumin on growth, digestive enzymes, immunity and antioxidant indices of crayfish (Procambarus clarkii)PubMed
2026
In crayfish fed 100 mg/kg dietary curcumin for 8 weeks, weight gain, digestive enzyme activity, complement C3 and antioxidant indices peaked versus other doses.
- [A study of soy protein proteolysis by digestive enzymes and description of the peptide profile of the obtained hydrolysates]PubMed
2026
In vitro pepsin and trypsin digestion of soy protein isolate released peptides that in silico tools predict to inhibit ACE and DPP-IV, with sequential hydrolysis reaching 7.71% hydrolysis.
- Non-Pancreatic Digestive EnzymesDOI
Biomolecules · 2025
This review describes salivary, gastric, and intestinal enzymes that digest food outside the pancreas and support nutritional health.
Barnyard millet (Echinochloa species): an underutilized nutritional powerhouse with emerging nutraceutical benefitsEmergingExpert review2026
Review found that phytic acid, tannins, and amylase inhibitors in barnyard millet bind minerals like calcium, zinc, and iron and limit their absorption, while processing methods such as soaking, fermentation, and germination can improve bioavailability.
Minnu Sasi; Veda Krishnan; Ramesh M Naik; Chandrika Das; Damodar Reddy Dendi; Aditya Nath Jha; Awadhesh K Pal; S R Arpitha; Aditi Raj; Akanksha Sharma; Kashish Shrestha; Karan
Effects of salivary amylase gene copy number on metabolic healthEmergingExpert review2026
This narrative review found that higher salivary amylase gene (AMY1) copy number is associated with greater postprandial glucose response and appears protective against insulin resistance, though links to adiposity remain inconsistent.
Sri Lakshmi Sravani Devarakonda; Kalem D Hanlon; Alex P Loinard-González; Bethany P Cummings; Angela C Poole
Mechanisms and Production of Hypoglycaemic Peptides: Exploring the Potential of Chlamydomonas reinhardtiiEmergingExpert review2026
This review reports that proteolytic peptides from the alga Chlamydomonas reinhardtii inhibit glucose-regulating enzymes alpha-amylase and alpha-glucosidase more strongly than plant protein sources.
Qian Li; Keying Su; Chunmin Yang; Xiaoyan Sun; Jing Huang; Saiyi Zhong; Lai-Hoong Cheng
A Review of Allergen Characteristics from Major Plant Allergenic FoodsEmergingExpert review2026
Plant food allergens vary significantly in heat and protease stability across major species; understanding these molecular characteristics is crucial for developing targeted processing methods to create hypoallergenic food products.
Xu Zhou; Jinshen Chu; Wenjing Du; Haochen Ye; Chen Wang; Xiaowen Pi
Lipase Stability in Structured Lipid Synthesis: The Interplay of Substrate Characteristics and Strategies to Improve Its Operational Performance-A Critical ReviewEmergingExpert review2026
Substrate pretreatment with antioxidants extended lipase operational stability up to sevenfold during structured lipid synthesis.
Evelyn Ling Lee; Eng-Seng Chan; Lee Fong Siow; Cher Pin Song; Yee-Ying Lee
Metabolic engineering of soybean for improving grain quality for animal consumptionEmergingExpert review2026
Metabolic engineering via CRISPR/Cas9 and RNAi can increase soybean protein content and quality while reducing phytate and protease inhibitor levels.
João Matheus Kafer; João Vitor da Silva; Suéllen Rosa de Almeida Polizeli; Rodrigo Thibes Hoshino; Juliana da Rosa; Elibio Leopoldo Rech Filho; Alexandre Lima Nepomuceno; Liliane Marcia Mertz-Henning
The Role of Monoacylglycerol Lipase (MAGL) in Substance Use: A Systematic Review of Preclinical StudiesEmergingExpert review2026
In a systematic review of preclinical studies, MAGL inhibition consistently reduced withdrawal across cannabis, opioid, and nicotine models but showed variable effects on reward.
Bertina Jebanesan; Khadija Brouillette; Caleb J Browne; Isabelle Boileau; Laura M Best
Recent advances in neurodegenerative diseases therapeutics: The inhibition of monoacylglycerol lipase strategyEmergingExpert review2026
In a review, MAGL inhibition reduced neuroinflammation and neurodegeneration in preclinical models of Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis.
Delia Maciel Mendoza-Camacho; Hugo Alejandro Espinoza-Gutiérrez; Juan Manuel Viveros-Paredes; Mario Eduardo Flores-Soto; Aldo Rafael Tejeda-Martínez
The biological functions of monoacylglycerol lipase (MAGL) in cancerEmergingExpert review2026
In a review, MAGL hydrolyzes 2-arachidonoylglycerol to produce arachidonic acid and free fatty acids that drive pro-inflammatory lipid mediators supporting tumor progression.
Faris Almutairi
System reconstruction of Bacillus licheniformis for efficient expression of alkaline proteaseEmergingPrimary research (design unspecified)2027
Genome reduction and expression-cassette optimization of Bacillus licheniformis raised alkaline protease activity 5.77-fold, reaching 34,343 U/mL in the final engineered host DM6E10.
Qing Zhang; Mengyuan Zhang; Zhihao Zhu; Haijing Ma; Fei Mo; Jiaqi Lei; Shisi He; Yongqing Liao; Shihao Yan; Dongbo Cai; Shouwen Chen
FODMAP-Targeting Digestive Enzyme Blend for Management of Gastrointestinal Symptoms: A "Real-World" Pre-Post Intervention Cohort StudyEmergingPrimary research (design unspecified)2026
In an open-label pre-post study without a control group, most patients using FODMAP-targeting digestive enzymes for 4 weeks reported improved bloating, flatulence, and abdominal pain.
Alexander J Kaye; Sarah R Meyers; David Hachuel; Jocelyn Wells; Thomas Wallach; Savanna Thor
CLPX acquires an iron-sulfur cluster to sustain mitochondrial proteostasis in cancer cellsEmergingPrimary research (design unspecified)2026
Mitochondrial protease CLPX requires an iron-sulfur cluster for function, and iron chelation disrupts cluster assembly, leading to loss of proteostasis in cancer cells.
Chengquan Huang; Yixue Zhang; Han Gao; Yuxin Song; Shunchang Hu; Chaoyue Sun; Shiwen Duan; Dongxiao Ma; Xiumei Jiang; Gang Liu
Red Grape Pomace as a Valuable Source of Biomolecules With Inhibitory Effect on Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes: Eco-Friendly Extraction and Mechanism of InhibitionEmergingPrimary research (design unspecified)2026
Red grape pomace extract inhibited lipoxygenase, α-amylase, and α-glucosidase activities at 82-99%, suggesting potential anti-inflammatory and antidiabetic effects.
Nicoleta Balan; Silviu Măntăilă; Ilir Mërtiri; Elisabeta Irina Geana; Iuliana Aprodu; Gabriela Râpeanu; Nicoleta Stănciuc
Multi-protease supplementation enhances growth performance and promotes gut health in broilers fed low-protein, low-amino acid dietsEmergingPrimary research (design unspecified)2026
In broiler chickens fed reduced-protein, low-amino-acid diets, adding a multi-protease enzyme at 200-300 g/t restored growth performance to normal-protein control levels and improved intestinal villus height and cecal microbiota composition.
Márcia N Soares; Bindhu L Vasanthakumari; Laryssa F Bernardes; Antonio G Bertechini
Mixture design-based optimization of bioactivities in steamed grain and legume blendsEmergingPrimary research (design unspecified)2026
In a mixture-design study, optimized blends of steamed colored rice, sorghum, millet, and black soybean showed enhanced lipase inhibition and suppressed lipid accumulation in free-fatty-acid-treated HepG2 liver cells, driven mainly by flavonoids.
Narae Han; Moon Seok Kang; Hana Lee; Jin Young Lee; Yu-Young Lee; Junsoo Lee; Hyun-Joo Kim
Natural α-Amylase Inhibitors from Medicinal Herbs: In Vitro Evaluation of Extracts Prepared with Food-Compatible SolventsEmergingPrimary research (design unspecified)2026
Ethanol extracts of sage and blueberry leaf showed the strongest in vitro alpha-amylase inhibition (79.6% and 57.7%, respectively) among tested medicinal plant extracts, supporting potential antidiabetic use.
Mihailo Mladenović; Milica Milutinović; Nevena Đukić; Mirjana Rajilić-Stojanović
The Effect of Lactic Acid Bacteria Fermentation on the Anti-Diabetic Activity of Pumpkin PureeEmergingPrimary research (design unspecified)2026
Lactic acid bacteria fermentation of pumpkin puree increased alpha-amylase and alpha-glucosidase inhibition and enhanced glucose uptake in insulin-resistant L6 muscle cells, indicating improved antidiabetic potential.
Aqsa Qayyum; Shahid Ahmed Junejo; Zuoting Xu; Muhammad Zubair Hassan; Bingjie Liu; Zhong Chen
Physicochemical, Technofunctional and Antiglycaemic Properties of Telfairia occidentalis Leaf and Seed PowdersEmergingPrimary research (design unspecified)2026
Telfairia occidentalis leaf and seed powders inhibited alpha-amylase and alpha-glucosidase in vitro, with leaf powder showing stronger enzyme inhibition than seed powder though both were weaker than acarbose.
Tanyitiku MN; Petcheu ICN -- International journal of food science
Effect of maqui berry extract consumption on postprandial responses in mice: actions on digestive enzymes and relevance of DPP-IV inhibitionEmergingPrimary research (design unspecified)2026
In mice, maqui berry extract inhibited digestive enzymes including DPP-IV in vitro, and reduced postprandial glycemia after an oral glucose challenge, an effect attributed to DPP-IV inhibition rather than lipase or general alpha-glucosidase activity.
Lucini Mas A; Mosele JI; Carrieri C; Favari C; Bresciani L; Mena P; Fraga CG; Galleano M -- Food & function
Comparative Characterisation and In Vitro Metabolic Bioactivities of Fucoidan-Rich Extracts from Three South African Brown MacroalgaeEmergingPrimary research (design unspecified)2026
Fucoidan-rich extracts from three South African brown macroalgae species showed concentration-dependent inhibition of pancreatic lipase and alpha-glucosidase in vitro, with Sargassum incisifolium and Ecklonia radiata showing the strongest alpha-glucosidase inhibition.
Coleen E Grobler; Blessing Mabate; Justin B Safari; Brett I Pletschke
Phytochemical Profiling, In Vitro Bioactivity, and Network Pharmacology of Astragalus cruciatus Link Ethanolic Extract: Multitarget Mechanisms Underlying Potential Antidiabetic EffectsEmergingPrimary research (design unspecified)2026
An ethanolic extract of Astragalus cruciatus significantly inhibited alpha-amylase and alpha-glucosidase in vitro, with molecular docking and network pharmacology suggesting multitarget effects on insulin resistance and inflammation pathways.
Leila Bellebcir; Imene Derardja; Redouane Rebai; Luc Jasmin; Abdennacer Boudah
Effects of Osmanthus fragrans and Sophora japonica flower powders addition on hazardous compound formation, quality characteristics, and starch digestion in baked biscuitsEmergingPrimary research (design unspecified)2026
Adding Osmanthus fragrans or Sophora japonica flower powder to baked biscuits reduced formation of hazardous compounds like acrylamide and shifted starch toward slower digestibility by inhibiting alpha-amylase and alpha-glucosidase.
Yueliang Zhao; Xiangru Zhao; Daming Fan; Mingfu Wang; Hui Wang
Study on the Functional, Physiological, and Sensory Properties of Coffee Leaf Dark Tea Processed Using the Pile Fermentation Method of Pu-Erh TeaEmergingPrimary research (design unspecified)2026
Microbially inoculated pile fermentation of coffee leaf tea produced stronger in vitro alpha-amylase and alpha-glucosidase inhibition and reduced starch digestibility than spontaneous fermentation.
Yanbing Wang; Kun Zhang; Guosheng Xiong; Ping Du; Jianhua Dong; Jinxue Li; Xiaogang Liu; Zhenjia Chen
Elucidating the binding mechanism of Caralluma tuberculata metabolites with type 2 diabetes targets through molecular docking and dynamics simulationsEmergingPrimary research (design unspecified)2026
Molecular docking and dynamics simulations found that luteolin from Caralluma tuberculata bound most strongly and stably to alpha-amylase, sucrase, and alpha-glucosidase, enzymes relevant to type 2 diabetes.
Amir Ali; Zia-Ur-Rehman Mashwani; Ashfaq Ahmad; Juan Pedro Luna-Arias; Gabriela Medina-Pérez; Ajaz Ahmad
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Dissolve-It-All is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Dissolve-It-All pairs with for each. Nothing works in isolation; these share the same systems.
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take on an empty stomach, away from meals by an hour or two, with a full glass of water so the enzymes act systemically rather than on food. Follow the brand's serving size.
Use code HOLISTICLOVE at checkout.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get Dissolve-It-AllThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Dissolve-It-All is a blend of proteolytic (protein-digesting) enzymes taken between meals rather than with food. Many people use enzymes this way to support the body's normal, everyday breakdown and clearing processes. It fits people who like systemic enzyme support as part of a balanced routine.
FAQ
What does Dissolve-It-All support?
It supports the body's normal breakdown and clearing processes, provides proteolytic enzymes taken between meals, supports a healthy inflammation response already within normal range, and complements good hydration and a balanced routine.
How do I take it?
Take on an empty stomach, away from meals by an hour or two, with a full glass of water so the enzymes act systemically rather than on food. Follow the brand's serving size.
What makes it different?
The language stays honest -- it is an enzyme blend people take to support normal housekeeping, not a cleanse that fixes anything. What people use it for is a matter of preference.