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What it is
A vitamin K supplement carrying the whole family -- K1 plus K2 in both its MK-4 and MK-7 forms. Vitamin K is the cofactor the body uses to activate proteins like osteocalcin and matrix-Gla protein, the ones that direct calcium toward bone and away from soft tissue. Carrying all three forms covers both the fast-clearing (K1, MK-4) and the long-circulating (MK-7) members of the family.
Why the evidence supports it
Vitamin K's job is specific and well characterized: it switches on the calcium-handling proteins, and controlled trials of MK-7 show it measurably increases the active, carboxylated form of those proteins over months of use. That mechanism is why the full K family is favored over a single fraction -- the forms clear at different rates and reach different tissues. Full circle, this is the cell's Build function: activating the proteins that guide calcium into the bone matrix rather than soft tissue. One real caution -- vitamin K interacts with blood thinners, so anyone on those needs a doctor's sign-off first.
What it supports
- Supports the body's normal handling of calcium toward bone
- Supports healthy bone metabolism
- Works alongside vitamin D and calcium
- Provides the full K family (K1, MK-4, MK-7)
Which function it supports
Ties to the cell's Build function -- vitamin K activates the proteins that guide calcium into bone rather than soft tissue.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (2 profiled ingredients). Structure and function only -- not a treatment claim.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: systematic review and meta-analysis of RCTs
Frontiers in Public Health · 2022
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: systematic review and meta-analysis of RCTs, Frontiers in Public Health, 2022
- [Vitamin K2]
Clinical calcium · 2008
A systematic review of 7 randomized controlled trials found that vitamin K2 (particularly menaquinone-4) supplementation increased bone mineral density and reduced fracture incidence in osteoporosis patients.
- Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial
Atherosclerosis · 2025
In 388 men aged 65-74 over 24 months, daily vitamin K2 (720 µg) and D3 (25 µg) significantly lowered markers of vitamin K deficiency but showed no effect on epicardial adipose tissue or systemic inflammation.
- Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial
Circulation · 2023
Two years of combined MK-7 and vitamin D supplementation did not slow progression of aortic valve calcification in men with existing calcification, another honest null finding for a specific hard cardiovascular endpoint.
- Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2000
In 92 postmenopausal women with osteoporosis over 2 years, combined vitamin D3 (0.75 µg/day) and vitamin K2 (45 mg/day) produced significantly greater lumbar bone mineral density increases than individual nutrients or calcium.
- Low-Dose Daily Intake of Vitamin K2 (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trial
PMID 26875489
Low-Dose Daily Intake of Vitamin K2 (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trial, PMID 26875489
Vitamin K professional fact sheetSystematic review2024
Summarizes vitamin K biology, coagulation-factor and osteocalcin/MGP carboxylation roles, and interaction with warfarin.
NIH Office of Dietary Supplements -- NIH ODS fact sheet
Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal WomenEmergingRandomized controlled trial2025
One year of MK-7 supplementation was associated with improvements in some vascular stiffness and blood pressure measures in postmenopausal women, consistent with the earlier three-year trial in the same population.
Femke de Vries; Rudolf Bittner; Katarzyna Maresz; François Machuron; Olav Gåserød; Jean-François Jeanne; Leon J Schurgers -- Nutrients
Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled TrialContestedRandomized controlled trial2023
In hemodialysis patients, one year of MK-7 supplementation did not significantly improve overall arterial stiffness versus standard care, a clear null result in this high-risk population.
Nuanjanthip Naiyarakseree; Jeerath Phannajit; Wichai Naiyarakseree; Nanta Mahatanan; Pagaporn Asavapujanamanee; Sookruetai Lekhyananda; Supat Vanichakarn; Yingyos Avihingsanon; Kearkiat Praditpornsilpa; Somchai Eiam-Ong; Paweena Susantitaphong -- Nutrients
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical TrialContestedRandomized controlled trial2023
Two years of combined MK-7 and vitamin D supplementation did not slow progression of aortic valve calcification in men with existing calcification, another honest null finding for a specific hard cardiovascular endpoint.
Axel C.P. Diederichsen; Jes S. Lindholt; Sören Möller; Kristian A. Øvrehus; Søren Auscher; Jess Lambrechtsen; Susanne E. Hosbond; Dilek H. Alan; Grazina Urbonaviciene; Søren W. Becker; Maise H. Fredgart; Selma Hasific -- Circulation
Vitamins formed by microorganisms in fermented foods: effects on human vitamin status-a systematic narrative reviewEstablishedSystematic review2025
In a systematic review of human studies, fermenting foods with specific bacteria raised levels of vitamins K2, B2, B9, and B12, with folate status improved by Camembert cheese and vitamin K2 status improved by natto.
Erhan Keyvan; Elizabeth Adesemoye; Marie-Christine Champomier-Vergès; Emilie Chanséaume-Bussiere; Julie Mardon; Daniela Nikolovska Nedelkoska; Recep Palamutoglu; Pasquale Russo; Inga Sarand; Laurencia Songre-Ouattara; Biljana Trajkovska; Sibel Karakaya; Michail Syrpas; Christophe Chassard; Smilja Pracer; Guy Vergères; Daniel Heine; Christèle Humblot
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: systematic review and meta-analysis of RCTsMeta-analysis2022
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: systematic review and meta-analysis of RCTs, Frontiers in Public Health, 2022
Ming-ling Ma; Zi-jian Ma; Yi-lang He; Hao Sun; Bin Yang; Bin-jia Ruan; Wan-da Zhan; Shi-xuan Li; Hui Dong; Yong-xiang Wang -- Frontiers in Public Health
The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysisEstablishedMeta-analysis2024
Meta-analysis of 17 RCTs showed vitamin K supplementation significantly reduced HOMA-IR (insulin resistance) by 0.24 units compared to placebo, with vitamin K2 showing greater effect than K1.
Qiu-Yan Zhao; Qiu Li; Minoo Hasan Rashedi; Mohammadhassan Sohouli; Pejman Rohani; Periyannan Velu
Vitamin K for the primary prevention of cardiovascular diseaseEstablishedSystematic review2015
A Cochrane review of insufficient evidence found one small 60-patient trial showed no effect of 3-month menaquinone supplementation on blood pressure or lipids for cardiovascular disease prevention.
Louise Hartley; Christine Clar; Obadah Ghannam; Nadine Flowers; Saverio Stranges; Karen Rees
Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trialEstablishedRandomized controlled trial2025
In 388 men aged 65-74 over 24 months, daily vitamin K2 (720 µg) and D3 (25 µg) significantly lowered markers of vitamin K deficiency but showed no effect on epicardial adipose tissue or systemic inflammation.
Hasific S; Ravn EJ; Rasmussen LM; Mejldal A; Dey D; Frandsen NE; Lindholt JS; Auscher S; Lambrechtsen J; Hosbond S; Alan D; Urbonaviciene G; Becker S; Øvrehus KA; Diederichsen A -- Atherosclerosis
Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants.EmergingClinical trial2022
A 12-month study of 1,062 people who chose to take nattokinase, with no placebo group, found improved lipid and artery measures, more so with smoking, drinking, higher BMI, and added vitamin K2 or aspirin.
Chen H; Chen J; Zhang F; Li Y; Wang R; Zheng Q; Zhang X; Zeng J -- Frontiers in cardiovascular medicine
The effect of six-month oral vitamin K supplementation on calcification propensity time in individuals with type 2 diabetes mellitus: A post hoc analysis of a randomized, double-blind, placebo-controlled trialEstablishedRandomized controlled trial2024
In 68 adults with type 2 diabetes over 6 months, menaquinone-7 supplementation (360 µg/day) showed no effect on serum calcification propensity (T50) compared to placebo.
Meer R; Romero Prats ML; Vervloet MG; van der Schouw YT; de Jong PA; Beulens JWJ -- Atherosclerosis
Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation.EmergingClinical trial2022
A clinical trial on Nattokinase found that vitamin K has been associated with a reduced risk of osteoporosis, cancer, and cardiovascular diseases (due to improved vascular elasticity).
Gasmi A; Bjørklund G; Peana M; Mujawdiya PK; Pivina L; Ongenae A; Piscopo S; Severin B -- Critical reviews in food science and nutrition
Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trialEstablishedRandomized controlled trial2023
Vitamin K status strongly improved in MK-7-supplemented participants. After 2 years, an accelerated BMD loss of the 1/3 distal radius was found with MK-7 supplementation {mean difference of changes relative to placebo -0.
Levy-Schousboe K; Marckmann P; Frimodt-Møller M; Peters CD; Kjærgaard KD; Jensen JD; Strandhave C; Sandstrøm H; Hitz MF; Langdahl B; Vestergaard P; Brasen CL; Schmedes A; Madsen JS; Jørgensen NR; Frøkjær JB; Frandsen NE; Petersen I; Hansen D -- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Study protocol of the InterVitaminK trial: a Danish population-based randomised double-blinded placebo-controlled trial of the effects of vitamin K (menaquinone-7) supplementation on cardiovascular, metabolic and bone healthEstablishedClinical trial2023
This randomized trial protocol (450 adults, 3 years) will test whether daily MK-7 supplementation prevents progression of coronary artery calcification.
Kampmann FB; Thysen SM; Nielsen CFB; Kofoed KF; Køber L; Pham MHC; Vaag A; Jørgensen NR; Petersen J; Jacobsen RK; Kårhus LL; Diederichsen A; Frimodt-Møller M; Linneberg A -- BMJ open
Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie StudyEstablishedRandomized controlled trial2020
In 132 hemodialysis patients with atrial fibrillation over 18 months, high-dose vitamin K2 (2000 µg thrice weekly) with rivaroxaban improved vitamin K status markers but showed no effect on vascular calcification progression.
De Vriese AS; Caluwé R; Pyfferoen L; De Bacquer D; De Boeck K; Delanote J; De Surgeloose D; Van Hoenacker P; Van Vlem B; Verbeke F -- Journal of the American Society of Nephrology : JASN
Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trialEstablishedClinical trial2017
plantation, and the change in 24-hour mean arterial pressure, the improvement in arterial stiffness was independently associated with the reduction in dp-ucMGP concentration (P =.
Mansour AG; Hariri E; Daaboul Y; Korjian S; El Alam A; Protogerou AD; Kilany H; Karam A; Stephan A; Bahous SA -- Journal of the American Society of Hypertension : JASH
The biological responses of vitamin K2: A comprehensive reviewEmergingExpert review2023
A comprehensive review found vitamin K2 acts across multiple body systems promoting osteogenesis, preventing calcification, enhancing mitochondrial energy, with hepato- and neuroprotective effects, though data remain inconsistent.
Quanxiang Yan; Tao Zhang; Christine O'Connor; James W Barlow; John Walsh; Gaia Scalabrino; Feng Xu; Helen Sheridan
Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and OpportunitiesExpert review2022
This review maps the molecular pathways through which the MK-7 form of vitamin K2 is thought to support tissues outside the liver.
Nikita Jadhav; Saiprasad Ajgaonkar; Praful Saha; Pranay Gurav; Amitkumar Pandey; Vivek Basudkar; Yash Gada; Sangita Panda; Shashank Jadhav; Dilip Mehta; Sujit Nair -- PubMed Central (PMC)
Vitamin K2 -- a neglected player in cardiovascular health: a narrative reviewEmergingExpert review2021
Multiple prospective studies show vitamin K2 intake associated with 14-57% reduced all-cause and cardiovascular mortality; strongest evidence for K2 (not K1) in upper intake tertiles.
Essa Hariri; Nicholas Kassis; Jean‐Pierre Iskandar; Leon J. Schurgers; Anas M. Saad; Omar Abdelfattah; Agam Bansal; Toshiaki Isogai; Serge C. Harb; Samir Kapadia -- Open Heart
Relationship between Structure and Biological Activity of Various Vitamin K FormsExpert review2021
This review found that vitamin K1 and MK-4 clear from plasma within 8 to 24 hours, while longer-chain menaquinones like MK-7 can still be detected up to 96 hours later.
Katarzyna Bus; Arkadiusz Szterk -- PubMed Central (PMC)
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and DiseaseExpert review2019
This review explains that vitamin K1 mainly supports liver clotting factor production while vitamin K2 forms are more available to bone and blood vessel tissue.
Maurice Halder; Ploingarm Petsophonsakul; Asim Cengiz Akbulut; Angelina Pavlic; Frode Bohan; Eric Anderson; Katarzyna Maresz; Rafael Kramann; Leon Schurgers -- International Journal of Molecular Sciences
Exploring Menatetrenone: Origin, Chemistry, Therapies and Delivery.EstablishedPrimary research (design unspecified)2025
A review examined menatetrenone, vitamin K2 MK-4, covering evidence for bone, cardiovascular and metabolic benefits and novel nanostructured lipid carrier delivery systems developed to improve its bioavailability.
Singh W, Kushwaha P, Kushwaha SP -- Journal of the American Nutrition Association
Development and application of a simple, high-throughput magnetic bead-assisted liquid chromatography-tandem mass spectrometry method for the quantification of vitamin K1 and vitamin K2 (menaquinone-4 and menaquinone-7) in human serumEmergingPreprint2026
A novel high-throughput magnetic bead LC-MS/MS method quantified vitamin K1, MK-4, and MK-7 in human serum with linear ranges 0.2--10 ng/mL and coefficients of variation 2--4% in 245 healthy volunteers.
Yinglan Zhu; Yu Zhou; Jing Du; Yanan Wang; Lingli Yan; Yangxiao Zhou; Jun Xia
Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK-1/SIR-2.1/DAF-16 Signaling Axis in Caenorhabditis elegans.2026
In C. elegans, low-dose vitamin K2 at 5 micromolar extended lifespan and improved stress resistance by maintaining mitochondrial morphology through the JNK-1/SIR-2.1/DAF-16 signaling axis, while higher doses were toxic.
Guo SY; Li YQ; Piao H; Zheng WF; Li SQ; Liu ZY; Lv JT; Kong Y; Li QF; Wang YZ; Li SZ; Zhao CL; Li S -- Aging cell
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Vitamin D (25-Hydroxyvitamin D)emerging evidence
via Vitamin K · 10 studies, 6 in people
Directs the calcium that vitamin D makes available into bone rather than soft tissue.
What people often notice when this marker sits outside the usual range
Higher: Excess comes from supplements, essentially never from sun.
Lower: Fatigue -- our library holds an explicit study of 25(OH)D and fatigue severity in adults.
- Bone Health: DEXA / T-score, CTX, P1NPemerging evidence
via Vitamin K · 4 studies, 2 in people
Carboxylates osteocalcin, which is a plausible and specific mechanism.
What people often notice when this marker sits outside the usual range
Higher: A high T-score is favourable; very high values occasionally reflect degenerative change in the spine artificially inflating the reading.
Lower: Bone loss is SILENT until a fracture.
- Vitamin D, Calcium, and Parathyroid Hormone (PTH)emerging evidence
via Vitamin K · 4 studies, 2 in people
Carboxylates osteocalcin and matrix Gla protein -- a specific, plausible mechanism.
What people often notice when this marker sits outside the usual range
Lower: CALCIUM LOW: tingling around the mouth and in fingers, muscle cramps and twitching, irritability.
- Calciumemerging evidence
via Vitamin K · 1 studies, 0 in people
Carboxylates osteocalcin and matrix Gla protein -- the proteins that put calcium into bone and keep it out of arteries.
What people often notice when this marker sits outside the usual range
Higher: "Bones, stones, groans and psychic moans" -- the old teaching phrase, and still the best summary: bone pain, kidney stones, abdominal pain and constipation, low mood and confusion.
Lower: Tingling around the mouth and in the fingers and toes.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Purely-K is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Purely-K pairs with for each. Nothing works in isolation; these share the same systems.
For Bone & Cartilage
For Foundation Nutrition
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take with a meal that contains some fat, since vitamin K is fat-soluble. It pairs naturally with vitamin D at the same meal. If you take a blood thinner such as warfarin, do not start this without your doctor's guidance. Follow the label.
Use code HOLISTICLOVE at checkout.
Where to get it
We are lining up the best way to get this one to you. In the meantime, reach out and we will point you the right way -- or browse the full shop to see every product.
See the full shopThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Purely-K carries the whole vitamin K family -- K1 plus K2 in both MK-4 and MK-7 forms. Vitamin K is part of how the body activates the proteins that direct calcium where it belongs, toward bone. It fits people who want the full K family working alongside their vitamin D and calcium.
FAQ
What does Purely-K support?
It supports the body's normal handling of calcium toward bone and healthy bone metabolism, works alongside vitamin D and calcium, and provides the full K family (K1, MK-4, MK-7).
How do I take it?
Take with a meal that contains some fat, since vitamin K is fat-soluble. It pairs naturally with vitamin D at the same meal. If you take a blood thinner such as warfarin, do not start this without your doctor's guidance.
What makes it different?
It carries the full K family rather than a single fraction. Vitamin K is a quiet nutrient that works alongside vitamin D and calcium, and most people rarely think about it.