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What it is
An evening drink scoop combining magnesium (about 225 mg, delivered as a well-tolerated citrate form that fizzes when mixed with warm water), saffron stigma extract (14 mg), and a low dose of melatonin (1 mg). Mixed into warm water about 30 minutes before bed, it is built to support an easier wind-down and a healthy sleep rhythm rather than to knock you out.
Why the evidence supports it
This is a well-reasoned sleep blend because each active is dosed to match its own research: saffron extract has placebo-controlled sleep-quality trials at about this amount, magnesium has human work on subjective sleep in people who run low, and melatonin's role in resetting the sleep-wake clock is among the more studied in supplement science — kept deliberately low here at 1 mg. There is also a double-blind, placebo-controlled study on the blend itself (formulated without melatonin) reporting improved sleep quality. That makes it an evidence-based nudge for the Mind's Regulate function — the circadian and calming signals that help the body downshift toward sleep — meant to support a routine, not replace one. The saffron is worth a closer look: it is one of the most-studied botanicals for mood and cognition, and its mechanism is specific — it modulates serotonin reuptake, the same target the SSRI class of medications acts on, alongside effects studied for memory. That is why its trial base runs so deep — saffron has even been compared head-to-head against reference medications in randomized trials and meta-analyses and matched or beat them on the endpoints those studies measured (the trials are linked in the studies below, so you can read them yourself). The line we hold is clear: this is structure/function support for a balanced mood and healthy cognition, and a mechanism worth understanding — not a treatment for any condition and not a substitute for prescribed medication, which are decisions for your doctor.
What it supports
- Supports an easier evening wind-down
- Supports a healthy, regular sleep rhythm
- Supports nervous-system calm before bed
- Provides magnesium, a mineral many people run low on
Which function it supports
Ties to the Mind world's Regulate function — supporting the circadian and calming signals that help the body downshift toward sleep.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below — follow either link to see the mechanism in full, then dig into the studies.
What it is made of — and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions — follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only — not a treatment claim.
The science on the ingredients
Magnesium Sulfate as an Adjuvant to Local Anesthetic in Erector Spinae Plane Block: A Systematic Review of Randomized Controlled Trials.EmergingSystematic review2026
A systematic review on Magnesium found that current randomized evidence does not support routine use of MgSO4 as an adjuvant in ESPB.
Gaetano D; Brunetti S; Lomonaco V; Piccialli F; Buglione A; Colella U; Coppolino F; Pota V; Passavanti MB; Sansone P — Life (Basel, Switzerland)
Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.ContestedMeta-analysis2026
A meta-analysis on Magnesium found that mgCl₂ demonstrated stronger HDL-C improvement in subgroup analysis.
Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S — Journal of diabetes and metabolic disorders
Systematic review and meta-analysis of 38 RCTs (2,709 participants)Meta-analysis2025
Magnesium supplementation lowered systolic BP ~2.8 mmHg and diastolic ~2.1 mmHg; larger effect in hypertensive/hypomagnesemic subgroups.
Study authors — Hypertension
A Comprehensive Review of Electrolyte Imbalances and Their Applied AspectsSystematic review2025
This review covers how sodium, potassium, and magnesium are tightly regulated to maintain fluid balance, nerve conduction, muscle contraction, and cell membrane function.
Study authors — PMC
The effects of magnesium L-threonate (Magtein ) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.EmergingRandomized controlled trial2026
Magtein was well-tolerated, and there were no reports of significant adverse reactions. (Magnesium evidence)
Lopresti AL; Smith SJ — Frontiers in nutrition
Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled TrialRandomized controlled trial2025
In healthy adults with self-reported poor sleep, 250 mg of magnesium bisglycinate daily for four weeks improved insomnia severity scores more than placebo.
Study authors — Nature and Science of Sleep
Sequence-Dependent Analgesic Efficacy of Ketamine and Magnesium Sulfate After Radical Nephrectomy.EmergingRandomized controlled trial2026
A randomized controlled trial on Magnesium found that intraoperative ketamine followed by MgSO4 (K → Mg) provides clinically meaningful postoperative analgesia after open radical nephrectomy; the reversed sequence (Mg → K) offers no benefit over placebo.
Ladjevic NN; Dzamic Z; Jovanovic VD; Petrovic ND; Sreckovic SD; Lazic MM; Terzic B; Likic Ladjevic I; Ladjevic N — Medicina (Kaunas, Lithuania)
Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized Placebo-Controlled TrialRandomized controlled trial2025
In 155 adults with poor sleep, 250mg/day elemental magnesium bisglycinate for four weeks was associated with a modest improvement in Insomnia Severity Index scores versus placebo.
Schuster J, Cycelskij I, Lopresti A, Hahn A — Nature and Science of Sleep
Clinical Effects of the Concurrent Ingestion of Rosuvastatin and Magnesium Oxide: A Multicenter, Randomized, Parallel-Group Trial.EmergingRandomized controlled trial2025
A randomized controlled trial on Magnesium found that the concurrent use of RSV and MgO did not significantly impact the reduction in LDL-C levels compared with the staggered administration.
Nakashima A; Tokura K; Misaki M; Miyazu D; Kobayashi K; Urata H; Watanabe H; Shimomura H; Miyazaki M; Imakyure O — Journal of clinical medicine research
Single Center, Open-Label, Randomized Crossover Trial on Drug-Drug Interactions of Levothyroxine/Magnesium-Citrate and Levothyroxine/Magnesium-Aspartate in Healthy Subjects-The ThyroMag Trial.EmergingRandomized controlled trial2025
A randomized controlled trial on Magnesium found that we found smaller effects compared to those already described for other divalent cations, possibly due to the liquid formulation.
Attinger MC; von Felten S; Rodrigues CL; Krützfeldt J; Risch L; Bonzon J — Clinical and translational science
Magnesium as an endocrine modulator: physiological roles, clinical evidence, and therapeutic perspectivesEstablishedExpert review2026
This review synthesises evidence that magnesium status influences hormone secretion and signalling across glucose metabolism, bone, thyroid function, reproduction and HPA axis activity.
Palermo A; Naciu AM; Zavatta G; Sargentini E; Menale C; Yavropoulou MP; Cipriani C; Tabacco G; Anastasilakis AD — European Journal of Endocrinology
Magnesium sulfate pharmacology for maternal and critical-care indications: mechanisms, pharmacokinetics, and the therapeutic window.EmergingExpert review2026
An expert review found that collectively, this review reframes magnesium sulfate as part of an integrated maternal and critical-care safety bundle and proposes a research agenda that links pharmacology, clinical trials, and implementation science to safer and more equitable use.
Xia M; Ni Q; Zhu S — Frontiers in pharmacology
Clinical Efficacy of Magnesium in Perioperative Pain Management: A Narrative Review.ContestedExpert review2025
An expert review on Magnesium found that no significant respiratory depression occurs in patients with normal renal function.
Ahmadzadeh S; Wentling JG; Ford BM; Yew JAT; Barrie SA; Bernhardt FY; Shekoohi S; Abd-Elsayed A; Kaye AD — Current pain and headache reports
Iron Metabolism, Calcium, Magnesium and Trace Elements: A ReviewExpert review2024
Iron, calcium, magnesium, and trace elements interact in shared absorption pathways in the gut, so the intake and status of one can influence uptake of another.
Rolić T, Yazdani M, Mandić S, Distante S — Biological Trace Element Research
Magnesium (Mg2+): Essential Mineral for Neuronal Health: From Cellular Biochemistry to Cognitive Health and Behavior Regulation.EmergingExpert review2024
An expert review on Magnesium found that supplementation with Mg2+, particularly in the form of bioavailable compounds such as Magnesium-L-Threonate (MgLT), Magnesium-Acetyl-Taurate (MgAT), and other Magnesium salts, has shown some promising results in enhancing synaptic density, improving memory function.
Kumar A; Mehan S; Tiwari A; Khan Z; Gupta GD; Narula AS; Samant R — Current pharmaceutical design
Chemical Analysis of Native Himalayan Shilajit: An Evaluation of an Ayurvedic FormulationEmergingTechnology-validation study2025
Multi-technique elemental and organic-compound analysis of a specific native Himalayan shilajit sample found potassium, calcium, and magnesium as predominant elements, source-specific to that sample.
Study authors — ACS Omega
Combined application of nano-magnesium oxide and humic acid improves potato drought tolerance and soil health.2026
In potato plants, combined humic acid and nano-magnesium oxide foliar application counteracted drought-induced reductions in chlorophyll, biomass, and tuber starch by enhancing antioxidant enzyme activity and reducing oxidative damage markers.
Zhang B; Yuan Z; Liu Y; Wang J; Rehman M; Chen A; Deng G; Wang H — BMC plant biology
Electrohydrodynamic-Printed Dual-Triphase Microfibrous Scaffolds Reshaping the Lipidomic Profile for Enthesis Healing in a Rat Rotator Cuff Repair Model.2025
In a rat rotator cuff injury model, dual-triphase microfibrous scaffolds enhanced with nano-magnesium-oxide and kartogenin reshaped the lipid profile at the enthesis, improving cellular differentiation and biomechanical healing outcomes.
Bai L; Kasimu A; Wang S; Qiu Z; Xu M; Qu X; Chen B; Liu Q; Ai Y; Li M; Xiu J; Liu K; Wen N; He J; Zhang J; Yin Z — Small (Weinheim an der Bergstrasse, Germany)
Acid-Neutralizing Omeprazole Formulation for Rapid Release and Absorption.2025
Researchers developed a fast-absorbing omeprazole capsule using magnesium oxide and sodium bicarbonate as acid neutralizers instead of enteric coating, achieving gastric acid neutralization within five minutes and peak drug levels within 30 minutes in human testing.
Ramesh S; Zvoníček V; Pěček D; Pišlová M; Beránek J; Hofmann J; Dumicic A — Pharmaceutics
A multinational cross-sectional study on knowledge, attitudes, and practices towards magnesium supplements.2025
A multinational survey found most respondents recognized magnesium's role in easing muscle spasm and sleep issues, yet knowledge scores were low overall and only about a third reported actually using magnesium supplements.
Abutaima R; Barakat M; Thiab S; Sawan HM; Amer M; Alzayer R; Abdelaziz DH; Mansour NO; Saleh F; Dayyih WA — Frontiers in pharmacology
Defecation after magnesium supplementation enhances cognitive performance in triathletes.2025
In a crossover trial with elite triathletes, magnesium-oxide-induced defecation was linked to faster Stroop test completion times, suggesting a rectum-brain connection in next-morning cognitive performance.
Wei CC; Harris MB; Ye M; Nicholls A; Alkhatib A; Dewi L; Huang CY; Kuo CH — Sports medicine and health science
Minerals and Human Health: From Deficiency to Toxicity.2025
Review describes calcium, magnesium, and phosphate deficiencies as contributing to osteoporosis, cardiovascular events, and neuromuscular dysfunction, while excess intake of minerals like calcium or iron can cause kidney stones, cardiac arrhythmias, or oxidative organ damage.
Razzaque MS; Wimalawansa SJ — Nutrients
Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation.2025
Systematic review and meta-analysis suggests magnesium supplementation may help regulate inflammation, though its direct effect on oxidative stress markers remains uncertain and needs further high-quality clinical trials.
Cepeda V; Ródenas-Munar M; García S; Bouzas C; Tur JA — Antioxidants (Basel, Switzerland)
Neurotransmitter Mechanisms of Ketamine and Ketamine-Magnesium Sulfate-Induced Hypothermia: Evidence for Serotonergic and Adrenergic Involvement Without GABAA Contributions.EmergingAnimal study2026
An animal study on Magnesium found that these results provide new mechanistic insights into NMDA antagonist-related thermoregulation and may help inform anesthetic strategies for shivering prevention and maintenance of perioperative thermal stability.
Savić Vujović K; Vučković S; Samardžić L; Medić B; Srebro D; Jotić A; Ćirković I — Brain sciences
Balanced by design — we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above — Sense, Exchange, Transform, Build, Maintain, Adapt — needs the same broad base of optimal micronutrient levels running underneath it, all the time. MYND360 Night Time is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal — here is what MYND360 Night Time pairs with for each. Nothing works in isolation; these share the same systems.
For Brain & Sleep
For Mood & Hormones
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational — a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it — go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Mix one scoop into water about 30 to 60 minutes before bed. It provides roughly 225 mg magnesium, 14 mg saffron, and 1 mg melatonin per scoop. Start low with melatonin if you are sensitive.
Where to get it
We are lining up the best way to get this one to you. In the meantime, reach out and we will point you the right way — or browse the full shop to see every product.
See the full shopThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
MYND360 Night Time is an evening drink scoop combining magnesium, saffron extract, and a low dose of melatonin. It is aimed at supporting an easier wind-down and a healthy sleep rhythm rather than knocking you out. It fits people who want a gentle nudge toward their natural sleep timing.
Common questions
What does MYND360 Night Time support?+
It supports an easier evening wind-down, a healthy regular sleep rhythm, and nervous-system calm before bed, and it provides magnesium, a mineral many people run low on.
How do I take it?+
Mix one scoop into water about 30 to 60 minutes before bed. The melatonin is kept low, so start low if you are sensitive to it.
What makes it different?+
The saffron and melatonin amounts line up with what small studies actually used, and the melatonin is kept low. It is gentle circadian and wind-down support that helps a routine rather than replacing one.