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What it is
Niacinamide, a non-flushing form of vitamin B3, which the body converts into NAD+ -- a coenzyme every cell uses to shuttle electrons through energy metabolism. NAD+ is the workhorse molecule mitochondria depend on to turn fuel into ATP, and niacinamide is one of its direct dietary precursors.
Why the evidence supports it
The biochemistry here is textbook and settled: niacinamide feeds directly into NAD+, and NAD+ is central to the electron-transfer reactions mitochondria use to make energy -- it also supplies the NADPH the cell uses for antioxidant defense. That makes it a clean fit for the cell's Transform function, converting fuel into usable energy. It is the gentle, non-flushing form of B3, and expectations stay grounded -- feeding the energy pathway matters most when you are actually running low.
What it supports
- Supports the mitochondria as they produce cellular energy
- Provides niacinamide as an NAD+ precursor
- Supports healthy energy metabolism
- A gentle, non-flushing form of vitamin B3
Which function it supports
Ties to the cell's Transform function -- niacinamide feeds the NAD+ that mitochondria use to convert fuel into ATP energy.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (2 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision label image on the product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 1 capsule | Amount | % DV |
|---|---|---|
| Niacinamide | 500 mg | 3125% |
- Servings per container:
- 90
- Other ingredients:
- Vegetarian capsule (hypromellose and water), bamboo extract.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosaceaPubMed
Cutis · 2005
A 4-week trial found that a niacinamide-containing moisturizer improved measures of stratum corneum barrier function in people with rosacea.
- Green Chemistry Approaches to Copper Halide and Niacinamide Complexes Design Synthesis and CharacterizationSource
Texas Woman’s University: Repository@TWU · 2026
Research explores synthesis of copper halide-niacinamide coordination complexes using green chemistry methods to reduce toxic chemical use.
- Combination of Sodium Hyaluronate, Withania Somnifera Extract and
Niacinamide Improves Hydration and Skin Tone -- A Clinical StudyDOI
Current Cosmetic Science · 2023
A topical cream combining Withania somnifera extract, sodium hyaluronate and niacinamide was associated with improved skin hydration and reduced dark spots over 28 days in 46 Asian women in a non-comparative single-blind study.
- [Research Progress in Niacinamide in the Prevention and Treatment of Mouth and Systemic Diseases]PubMed
PubMed · 2023
This review summarized nicotinamide's antibacterial, anti-inflammatory, and immune-modulating effects in oral and systemic diseases, noting most evidence remains at the laboratory stage.
- Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and PigmentationPubMed
Antioxidants · 2021
Topical and oral nicotinamide supplementation reduces skin aging and hyperpigmentation by restoring NAD+ and reducing oxidative stress in clinical trials.
- Enhancing Niacinamide Skin Penetration via Other Skin Brightening Agents: A Molecular Dynamics Simulation Study.PubMed
International journal of molecular sciences · 2025
Computer simulations showed niacinamide barely penetrated skin's outer lipid layer alone, but combining it with three other brightening agents (Sepiwhite, bisabolol, sucrose dilaurate) increased its penetration by 32%, a simulation study.
Nicotinamide Supplementation in Glaucoma: A Systematic Review of Human StudiesEstablishedSystematic review2026
This systematic review of eight human studies found preliminary short-term inner retinal electrophysiology improvements with nicotinamide in glaucoma but inconsistent visual field effects, and insufficient evidence for sustained neuroprotection.
Andrea Giudiceandrea; Martina Cocuzza; Gianni Gravina; Valeria Silvestri; Filippo Amore; Marco Sulfaro; Francesco De Dominicis; Simone Bruzio; Epifanio Giudiceandrea; Matteo Salgarello; Grazia Maria Cozzupoli; Maria Cristina Savastano; Benedetto Falsini; Stanislao Rizzo; Tommaso Salgarello
Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsEstablishedMeta-analysis2026
Meta-analysis of randomized trials showed NMN supplementation reduced diastolic blood pressure modestly overall, with significant systolic BP reduction in adults over sixty.
Mu Zhang; Yingci Chen; Nan Jiang; Jingjing Zeng; Jianyun Zhang; Chenyang Wu; Yingying Liu; Zizheng Nie; Jun Yang; Shufen Han
Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trialEstablishedRandomized controlled trial2026
Combination nicotinamide riboside and exercise produced greater cardiopulmonary fitness improvements than either intervention alone in Friedreich's ataxia patients.
Kimberly Y Lin; Anna Bucha; Kara McSweeney; Kristin L Wade; Antoneta Karaj; Jaclyn Tamaroff; Shannon O'Malley; Nicole M Chung; Nicolette A Cilenti; Julianne Wanner; Gabriel K Adzika; Clementina Mesaros; Ian A Blair; Teerapat Rojsajjakul; Suraj Serai; Jennifer Farmer; Kyle Bryant; Yingying Lu; Michael O Harhay; David R Weber; Stephen M Paridon; Erin L Seifert; Mary E Putt; Payman Zamani; Joseph A Baur; David R Lynch; Shana E McCormack
Association between blood nicotinamide adenine dinucleotide levels and blood laboratory parameters at baseline and after nicotinamide mononucleotide supplementation in middle-aged healthy individuals: post hoc analysis of a randomized, double-blinded, placebo-controlled clinical trialEstablishedRandomized controlled trial2026
Higher baseline blood NAD was associated with increased lymphocytes and hemoglobin; NMN supplementation raised blood NAD and RBC parameters.
Ajla H Kuerec; Weilan Wang; Keona D M Fokke; Lin Yi; Zhigang Lin; Aditi Vaidya; Sohal Pendse; Sornaraja Thasma; Niranjan Andhalkar; Ganesh Avhad; Vidyadhar Kumbhar; Andrea B Maier
Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young MenEstablishedRandomized controlled trial2026
In a randomized trial of 39 healthy young men after damaging eccentric exercise, nicotinamide plus pyridoxine raised muscle stem cell markers by 29-67% and increased regenerating fibers by 37% versus placebo.
Grith Højfeldt; Joris Michaud; Ann Damgaard; Karoline Karlog; Eugenia Migliavacca; Sonia Karaz; Elham Pazirandeh-Micol; Odd E Johansen; Leonidas G Karagounis; Bjørk W Helge; William Hagemann; Michael Kjaer; Jerome N Feige; Pascal Stuelsatz; Abigail L Mackey
Symptom-Level Precision Neurology in Amyotrophic Lateral Sclerosis (ALS): Linking Microglial Pruning, Mitochondrial Nicotinamide Adenine Dinucleotide (NAD+) Compensation, and Autophagy Failure Across the Aging SpectrumEmergingExpert review2026
ALS symptom domains map to circuit vulnerabilities; synaptic fragility, failing NAD+ recovery, and autophagy collapse under aging stress drive heterogeneous disease progression.
Cheung N -- Cureus
NAD Metabolism in Acute Myeloid Leukaemia: Biological Rationale and Therapeutic OpportunitiesEmergingExpert review2026
Acute myeloid leukemia cells exhibit heightened dependence on the NAD salvage pathway, making nicotinamide phosphoribosyltransferase inhibition a targetable therapeutic vulnerability.
Somers K; Karsa M; Moujalled DM -- Nutrients
An Optimization Approach for the Production of High-Purity Vitamin C‑Nicotinamide Cocrystals by the Gas Antisolvent (GAS) Technique with CO2 and EthanolEmergingPrimary research (design unspecified)2026
Vitamin C-nicotinamide cocrystals produced via gas antisolvent method with carbon dioxide achieved 99% purity and 85.2% yield while preserving ascorbic acid antioxidant capacity and thermal stability.
Clóvis A Balbinot Filho; Thayli R Araujo; Jônatas L Dias; Evertan A Rebelatto; Adailton J Bortoluzzi; Mariana M Vernaschi; Tânia B Creczynski-Pasa; Sandra R S Ferreira; Marcelo Lanza
The Role of the Pentose Phosphate Pathway in Cardiovascular Diseases.2026
A review found that the pentose phosphate pathway generates NADPH and ribose-5-phosphate, supporting antioxidant defense and cell proliferation, with dual roles in cardioprotection and oxidative damage in cardiovascular disease.
Chen Z; Zhang Y; Qian C; Xia L -- Cardiovascular drugs and therapy
NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1 -- C/EBPβ -- STEAP4 -- NRF2 axisEmergingPrimary research (design unspecified)2026
Nicotinamide phosphoribosyl transferase ameliorates high-fat diet-induced nonalcoholic fatty liver disease through SIRT1-mediated antioxidant signaling and lipid metabolism regulation.
Jingwu Zhao; Qinjin Li; Yi Wang; Bingbing Liu; Sisi Gui; Yazhen Zheng; Xiaodong Chen -- Journal of Molecular Cell Biology
Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use.2026
A review compared pyrroloquinoline quinone and NMN/NR, finding that PQQ acts mainly through mitochondrial biogenesis and antioxidant pathways while NMN/NR serve as precursors for NAD+ synthesis supporting energy metabolism and DNA repair.
Ulpathakumbura S; Lu SK; Gunarathne R; Yang JZ; Liu J; Jin X; Zhou Q; Lu J -- Ageing research reviews
Nicotinamide Adenine Dinucleotide Augmentation in Diabetic Kidney Disease: Randomized Trial Study ProtocolEmergingPrimary research (design unspecified)2026
A phase 2a randomized trial is testing whether nicotinamide mononucleotide augmentation reduces albuminuria and improves kidney function biomarkers in adults with diabetic kidney disease.
Mohan Sonu Chandra; Thiago Gagliano-Jucá; Skand Shekhar; Karol M Pencina; Thomas G Travison; Rajesh Garg; Marie E McDonnell; Kieran F Reid; Nancy K Latham; Helen Lam; Diego Meritus; Yufei Yan; Ilean Isaza; Mary F Weiss; Yusnie M Beleva; Eric M Bracken; Elizabeth Ruiz; Christina Wang; John Forman; Sushrut S Waikar; Shalender Bhasin
Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance.2026
In mouse liver cancer models, chronic psychological stress suppressed the enzyme QPRT in hepatocytes, diverting kynurenine metabolism away from NAD+ synthesis and impairing liver CD8+ T cell immunity, accelerating cancer progression.
Sun R; Jiao D; Yuan W; Wang H; Ren L; Fu Z; Zhang J; Yue X; Wu Z; Li C; Hu H; Wang J; Gao L; Ma C; Liang X -- Nature metabolism
Effects of NAD⁺ repletion with Nicotinamide riboside on obesity-induced chronic kidney disease and renal cell lipotoxicityEmergingPrimary research (design unspecified)2026
Nicotinamide riboside supplementation showed antioxidant effects and improved mitochondrial function in renal cells but did not prevent obesity-induced metabolic dysfunction or chronic kidney disease in mice.
Morgane Decarnoncle; Louise Pierre; Marine Thirion; Hélène Marlier; Louis Maréchal; Pauline Rouzé; Inès Jadot; Thierry Arnould; Anne-Emilie Declèves; Florian Juszczak
Steroid-dependent metabolic rewiring reveals novel therapeutic and imaging approaches for glioblastoma.2026
In glioblastoma, dexamethasone-driven metabolism shunted nicotinamide toward N1-methylnicotinamide production via NNMT rather than NAD+ synthesis, a tumor-selective pathway exploited for a new imaging approach.
Allega MF; Deshmukh R; Hillinger T; Akhmetshina A; Oudin A; Bielik R; Soloviev D; Villar VH; Ackermann T; Bourmeau G; Chahal SK; Stevenson KH; Nixon C; Shaw R; Morrison GM; Chalmers AJ; Pollard SM; Lund-Johansen M; Bjerkvig R; Seano G; Niclou SP; Vik-Mo EO; Lewis DY; Sumpton D; Tardito S -- Science advances
Nicotinamide mononucleotide attenuates hyperandrogenism in a polycystic ovary syndrome-like rat model by suppressing NLRP3 inflammasome-mediated granulosa-cell pyroptosisEmergingPrimary research (design unspecified)2026
In a letrozole-induced PCOS rat model, nicotinamide mononucleotide reduced serum testosterone, restored estrous cyclicity, and suppressed NLRP3 inflammasome-driven granulosa cell pyroptosis in ovarian tissue.
Yiwen Zhang; Kongwei Huang; Weihua Nong; Zhenwei Guo; Qin Xie; Xiaocan Lei; Shun Zhang; Meixiang Li; Jiaming Zhang
Sarcopenia and Muscle Aging: Updated Insights into Molecular Mechanisms and Translational Therapeutics.2026
Sarcopenia, the age-related loss of muscle mass and function, involves mitochondrial dysfunction, declining NAD+ levels, and myokine dysregulation, with no approved pharmacological treatment yet available.
Nguyen TT; Dao T; Nguyen HT; Park JH; Jeong SJ; Kim S; Jo Y; Thieu NTH; Zhao J; Ding F; Yu Y; Dung VC; Gariani K; Kim BJ; Ryu D -- Endocrinology and metabolism (Seoul, Korea)
Nicotinamide Riboside Supplementation Protects Against Heat-Induced Skeletal Muscle Injury in Female MiceEmergingPrimary research (design unspecified)2026
Nicotinamide riboside supplementation reduced heat-induced muscle inflammation, oxidative stress, and mitochondrial impairment in female mice independent of NAD+ level changes.
Chen Y; Yu T -- Muscles (Basel, Switzerland)
Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise.2026
In a crossover trial of just 11 untrained young men given NMN for 7 days, it blunted post-exercise rises in inflammation and mitochondrial content after blood-flow-restricted exercise, and delayed muscle repair signals.
Yang DL; Chao KC; Yang HT; Chen KH; Dewi L; Condello G; Ye M; Nicholls A; Liao YC; Huang CY; Kuo CH -- Journal of the International Society of Sports Nutrition
Intravenous infusion of nicotinamide adenine dinucleotide (NAD+) versus nicotinamide riboside (NR): a retrospective tolerability pilot study in a real-world settingEmergingPrimary research (design unspecified)2026
Nicotinamide riboside IV was better tolerated than NAD+ IV, causing only minor paresthesias versus moderate-to-severe gastrointestinal symptoms and chest pressure.
Kirsten Reyna; Greer Heinzen; Nikita Patel; Marie Ritter; Alexandra Siojo; Henry Legere; Rachele Pojednic
Vitamin B3 derivatives support pancreatic cancer cell survival and chemotherapy resistance.2026
In pancreatic cancer models, nicotinamide mononucleotide supplementation increased tumor cell resistance to chemotherapy drugs oxaliplatin, 5-fluorouracil, and gemcitabine by improving mitochondrial function and reducing oxidative stress and DNA damage in cancer cells.
Nakazzi F; Zarei M; Lopes M; Graor HJ; Beegan WC; Gu E; Rezaei S; Lund PJ; Winter JM -- Cancer letters
Effects of nicotinamide riboside supplementation during late gestation and lactation on sow performance, milk metabolome, and gut microbiomeEmergingPrimary research (design unspecified)2026
Nicotinamide riboside supplementation shortened farrowing duration and increased milk yield while promoting beneficial gut microbiota remodeling in sows.
Long Huang; Xiaohan Yang; Chenglin Pan; Wei Zhang; Yingjie Li; Ruilan Zhang; Hua Li; Ying Li; Yong Zhuo; Xuemei Jiang; Lianqiang Che; Yan Lin; Shengyu Xu; Zhengfeng Fang; Bin Feng; De Wu; Lun Hua
Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma.2026
In intrahepatic cholangiocarcinoma cell models, chronic IL-6 signaling created metabolic vulnerability to nicotinamide phosphoribosyltransferase inhibition, disrupting mitochondrial fitness, while also altering the tumor secretome and suppressing macrophage efferocytosis in the tumor microenvironment.
Gehl V; O'Rourke CJ; Cornillet M; Nousias O; Fardellas A; Yangngam S; Rogalska-Taranta M; Aldana BI; Hogdall D; Marquardt JU; Björkström NK; Andersen JB -- Gut
Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6EmergingPrimary research (design unspecified)2026
Nicotinamide riboside supplementation prevented onset of mitochondrial respiration impairment and TCA cycle dysfunction in nemaline myopathy type 6 mice.
Rianne J Baelde; Leander A Vonk; Edgar E Nollet; Ricardo A Galli; Alexcia Fortes Monteiro; Sultan Bastu; Bornale Das; Michel van Weeghel; Bauke V Schomakers; Kasper T Vinten; Marloes van den Berg; Jolanda van der Velden; Riekelt H Houtkooper; Nicol C Voermans; Edoardo Malfatti; Coen A C Ottenheijm; Josine M de Winter
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. NAD-Power is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what NAD-Power pairs with for each. Nothing works in isolation; these share the same systems.
For Energy & Mitochondria
For Epigenetics
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take with water, with or without food, usually once daily. Follow the label rather than assuming more is better.
Use code HOLISTICLOVE at checkout.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get NAD-PowerThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
NAD-Power is niacinamide, a form of vitamin B3 the body uses to make NAD+ -- a molecule your mitochondria rely on to turn fuel into cellular energy. It is a simple, well-tolerated B vitamin behind a lot of energy metabolism. It fits people who want to support the energy pathway itself.
FAQ
What does NAD-Power support?
It supports the mitochondria as they produce cellular energy, provides niacinamide as an NAD+ precursor, supports healthy energy metabolism, and is a gentle, non-flushing form of vitamin B3.
How do I take it?
Take with water, with or without food, usually once daily. Follow the label rather than assuming more is better.
What makes it different?
The biochemistry is real and basic -- niacinamide feeds into NAD+, which is central to how mitochondria make energy. It is a straightforward, gentle form of B3 rather than the flushing kind.