When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
This is the daytime engine of ageLOC R2 — six morning capsules of cordyceps Cs-4, Panax ginseng, and pomegranate that work the epigenetics of energy. R2 is a two-part system: R2 Night runs the overnight genetic detox, and R2 Day targets the other side — the gene-expression patterns behind cellular ENERGY production, right where the mitochondria turn food into usable fuel. The daytime vitality that rides on that engine is the point: physical vigor, mental acuity, and sexual health.
Why the evidence supports it
The honest frame, straight from the product's own science, is energy — not detox (that is R2 Night's job). The ageLOC method behind R2 compared age-related gene-expression patterns and screened natural compounds for the ones that shifted the cellular-energy pattern toward a more youthful state, selecting cordyceps, ginseng, and pomegranate on that basis — and the ageLOC Vitality research it grew from mapped that gene modulation across three tissues at once: brain, heart, and skeletal muscle (the specific gene count is Nu Skin's own figure). Each ingredient carries its own human evidence for that daytime story: cordyceps Cs-4 for exercise capacity and oxygen use (VO2max), Panax ginseng for energy and fatigue, mental acuity, and sexual vitality in both men and women, and pomegranate for mitochondrial support. Graded honestly, most of that ingredient evidence is emerging rather than settled, and the finished-formula gene-expression claim is emerging — so this supports the cell's Transform function and daytime vitality, it does not treat fatigue or any condition.
What it supports
- Supports cellular energy production and mitochondrial function
- Supports daytime physical vigor and stamina
- Supports mental acuity and everyday cognition
- Supports healthy libido and sexual vitality in men and women
Which function it supports
Ties to the cell's Transform function — supporting youthful gene expression for cellular energy production (the mitochondria) across brain, heart, and skeletal muscle, and the daytime vitality that depends on it. NRF2/purification is R2 Night's role, not this one.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below — follow either link to see the mechanism in full, then dig into the studies.
What it is made of — and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions — follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only — not a treatment claim.
The science on the ingredients
The effect of Panax ginseng supplementation on markers of resistance exercise-induced muscle damage: a systematic reviewEmergingSystematic review2024
A PRISMA systematic review of RCTs found Panax ginseng may reduce markers of resistance-exercise-induced muscle damage, supporting a recovery/vigor role while calling for larger trials.
Morgans R; Scholten JS; Rhodes D; Ceylan HI; Ryan B; Oliveira R; Clifford T — The Journal of sports medicine and physical fitness
Ginseng for managing menopausal woman's health: A systematic review of double-blind, randomized, placebo-controlled trialsContestedSystematic review2016
A systematic review of double-blind RCTs of ginseng for menopausal health found possible benefits for some quality-of-life and sexual-function measures but judged the overall evidence inconclusive.
Lee HW; Choi J; Lee Y; Kil KJ; Lee MS — Medicine
Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational UseEmergingMeta-analysis2023
A systematic review and meta-analysis of dietary supplements for erectile dysfunction identified Panax ginseng among the better-supported single ingredients, though evidence quality was mixed.
Petre GC; Francini-Pesenti F; Vitagliano A; Grande G; Ferlin A; Garolla A — Nutrients
Panax ginseng in randomised controlled trials: a systematic reviewContestedSystematic review2013
A broad systematic review of Panax ginseng RCTs found no conclusive disease-treatment evidence, underscoring that ginseng's benefits sit in the structure/function and well-being range, not clinical cure.
Shergis JL; Zhang AL; Zhou W; Xue CC — Phytotherapy research : PTR
Exploratory Systematic Review and Meta-Analysis of Panax Genus Plant Ingestion Evaluation in Exercise EnduranceEmergingMeta-analysis2022
A systematic review and meta-analysis found Panax-genus plants and ginsenosides tended to extend time-to-exhaustion in endurance tests, but heterogeneity and unreported ginsenoside content weaken the conclusion.
Ikeuchi S; Minamida M; Nakamura T; Konishi M; Kamioka H — Nutrients
Ginseng for cognitionContestedMeta-analysis2010
A Cochrane meta-analysis found some short-term cognitive signals from ginseng but concluded there is no convincing evidence of a durable benefit in healthy adults, flagging the claim as unsettled.
Geng J; Dong J; Ni H; Lee MS; Wu T; Jiang K; Wang G; Zhou AL; Malouf R — The Cochrane database of systematic reviews
Using ginseng for menopausal women's health care: A systematic review of randomized placebo-controlled trialsEmergingSystematic review2022
An updated systematic review of placebo-controlled RCTs reported ginseng may improve select menopausal symptoms and sexual well-being, with effects modest and trial quality variable.
Lee HW; Ang L; Lee MS — Complementary therapies in clinical practice
Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for FatigueEmergingSystematic review2020
A systematic review of clinical and preclinical studies concluded Panax ginseng and its ginsenosides show a consistent anti-fatigue signal, while noting variable trial quality.
Jin TY; Rong PQ; Liang HY; Zhang PP; Zheng GQ; Lin Y — Frontiers in pharmacology
Red ginseng for treating erectile dysfunction: a systematic reviewEmergingSystematic review2008
A systematic review found the majority of randomized trials suggested Korean red ginseng improved erectile function versus placebo, while noting the trials were generally small and of modest quality.
Jang DJ; Lee MS; Shin BC; Lee YC; Ernst E — British journal of clinical pharmacology
Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled StudyEmergingRandomized controlled trial2025
A randomized placebo-controlled trial in moderately stressed adults found a high-rare-ginsenoside red Panax ginseng lowered perceived stress and improved some emotional-processing and cognitive measures.
Dormal V; Jonniaux L; Buchet M; Simar L; Copine S; Deldicque L — Nutrients
Short-Term Panax Ginseng Extract Supplementation Reduces Fasting Blood Triacylglycerides and Oxygen Consumption during Sub-Maximal Aerobic Exercise in Male Recreational AthletesEmergingRandomized controlled trial2024
A 14-day double-blind trial in male runners found Panax ginseng extract lowered oxygen consumption during sub-maximal aerobic exercise and reduced fasting triglycerides, hinting at improved exercise efficiency.
Hernández-García D; Granado-Serrano AB; Martín-Gari M; Ensenyat A; Naudí A; Serrano JCE — Biomolecules
Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialEmergingRandomized controlled trial2024
A 12-week randomized placebo-controlled trial reported a standardized Panax ginseng sprout extract improved memory test scores in older adults with subjective memory complaints.
Baek HI; Ha KC; Park YK; Kim TY; Park SJ — Nutrients
Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activityEmergingRandomized controlled trial2005
A double-blind crossover trial found single doses of standardized Panax ginseng (G115) improved accuracy on demanding mental-arithmetic tasks and lowered blood glucose during sustained mental effort in healthy adults.
Reay JL; Kennedy DO; Scholey AB — Journal of psychopharmacology (Oxford, England)
Pharmacological mechanisms and drug delivery systems of ginsenoside Rg3: A comprehensive reviewEmergingExpert review2025
A comprehensive review characterizes the rare ginsenoside Rg3 as a high-potency minor ginsenoside with broad antioxidant and anti-inflammatory activity but poor solubility, motivating enhanced-delivery formulations.
Yao ZW; Zhu H — Pharmacological research
Plant Adaptogens-History and Future PerspectivesLineageExpert review2021
A historical review classifies Panax ginseng among the classical plant adaptogens defined by their ability to raise nonspecific resistance to physical stress without increasing oxygen demand.
Todorova V; Ivanov K; Delattre C; Nalbantova V; Karcheva-Bahchevanska D; Ivanova S — Nutrients
Rare ginsenosides: A unique perspective of ginseng researchEmergingExpert review2024
A review defines rare ginsenosides (Rg3, Rh2, compound K) as deglycosylated products of processing or gut metabolism that are low in abundance yet substantially more potent than the primary ginsenosides they come from.
Fan W; Fan L; Wang Z; Mei Y; Liu L; Li L; Yang L; Wang Z — Journal of advanced research
Recent trends in ginseng researchEmergingExpert review2024
A review of recent ginseng research maps active ginsenosides to molecular targets and gene-expression pathways, while human nutrigenomic (transcriptome) trials of ginseng remain sparse.
Ito H; Ito M — Journal of natural medicines
Pharmacological Properties of Ginsenoside ReEmergingExpert review2022
A pharmacology review summarizes ginsenoside Re, a protopanaxatriol saponin, as having antioxidant, anti-inflammatory, and metabolic activities, positioning it as a notable minor contributor to whole-extract effects.
Gao XY; Liu GC; Zhang JX; Wang LH; Xu C; Yan ZA; Wang A; Su YF; Lee JJ; Piao GC; Yuan HD — Frontiers in pharmacology
Ginsenoside Compound K: Insights into Recent Studies on Pharmacokinetics and Health-Promoting ActivitiesEmergingExpert review2020
A review explains that compound K, a rare ginsenoside produced by gut-microbial biotransformation of major ginsenosides, is far more absorbable and soluble than its parent compounds, driving much of ginseng's realized bioactivity.
Sharma A; Lee HJ — Biomolecules
Ginsenoside Rb1 and mitochondria: A short review of the literatureEmergingExpert review2019
PRECLINICAL: A focused review describes how ginsenoside Rb1 supports mitochondrial energy synthesis and membrane stability and limits mitochondrial-driven apoptosis in cell and animal models.
Zhou P; Xie W; Sun Y; Dai Z; Li G; Sun G; Sun X — Molecular and cellular probes
Gut microbiota-mediated pharmacokinetics of ginseng saponinsEmergingExpert review2018
A review shows gut microbiota convert hydrophilic parent ginsenosides into more bioavailable metabolites (compound K, Rh1, Rh2), explaining why an individual's microbiome shapes the potency of a standardized ginseng dose.
Kim DH — Journal of ginseng research
Effects and mechanisms of ginseng and ginsenosides on cognitionEmergingExpert review2014
A review of human and preclinical data concludes ginseng and isolated ginsenosides show plausible cognition-supporting mechanisms, with clinical effects still modest and inconsistent.
Smith I; Williamson EM; Putnam S; Farrimond J; Whalley BJ — Nutrition reviews
Ginsenoside Rd alleviates LPS-induced neuroinflammation and depressive-like behaviors via regulating TLR4-PI3K-NF-κB-JMJD3 signalingEmerging2025
PRECLINICAL: Ginsenoside Rd modulated TLR4-PI3K-NF-kB signaling and the epigenetic demethylase JMJD3 to lower neuroinflammation in mice, illustrating ginsenoside effects on host gene-regulatory pathways.
Chen H; Piao J; Geng Z; Han X; Li R; Cui R; Li B — International immunopharmacology
Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling PathwayEmerging2021
PRECLINICAL: In C. elegans, total ginsenosides extended lifespan by activating conserved stress-response signaling and lipid-metabolism pathways, a mechanistic hint relevant to adaptogenic and longevity claims.
Yu X; Li H; Lin D; Guo W; Xu Z; Wang L; Guan S — International journal of molecular sciences
Balanced by design — we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above — Sense, Exchange, Transform, Build, Maintain, Adapt — needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC R2 Day is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal — here is what ageLOC R2 Day pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Energy & Mitochondria
For Mood & Hormones
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational — a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it — go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take six capsules in the morning, with or without food, and pair with R2 Night in the evening — the two halves are designed to be used together. Follow the current label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC R2 DayThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission — and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC R2 is a two-part daily system built to support the cell's own renewal and energy pathways as we age. One part leans toward daytime purification support, the other toward overnight energy and renewal support. It fits people who want a thoughtfully timed longevity routine rather than one generic pill.
Common questions
What does ageLOC R2 support?+
It supports the cell's natural renewal processes, the body's normal antioxidant defenses, healthy cellular energy production, and healthy cellular aging over time. It supports the body's own renewal; it does not reverse aging or reset genes.
How do I take it?+
Take the daytime portion in the morning and the evening portion at night, each with water, following the pack layout. The morning-and-night rhythm is the whole point, so keep both consistent.
What makes it different?+
It is two formulas timed to the body's day-and-night rhythm, aimed at supporting the cell's own maintenance machinery rather than a single all-day dose.