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What it is
This is the daytime engine of ageLOC R2 -- six morning capsules of cordyceps Cs-4, Panax ginseng, and pomegranate that work the epigenetics of energy. R2 is a two-part system: R2 Night runs the overnight genetic detox, and R2 Day targets the other side -- the gene-expression patterns behind cellular ENERGY production, right where the mitochondria turn food into usable fuel. The daytime vitality that rides on that engine is the point: physical vigor, mental acuity, and sexual health.
Why the evidence supports it
The honest frame, straight from the product's own science, is energy -- not detox (that is R2 Night's job). The ageLOC method behind R2 compared age-related gene-expression patterns and screened natural compounds for the ones that shifted the cellular-energy pattern toward a more youthful state, selecting cordyceps, ginseng, and pomegranate on that basis -- and the ageLOC Vitality research it grew from mapped that gene modulation across three tissues at once: brain, heart, and skeletal muscle (the specific gene count is Nu Skin's own figure). Each ingredient carries its own human evidence for that daytime story: cordyceps Cs-4 for exercise capacity and oxygen use (VO2max), Panax ginseng for energy and fatigue, mental acuity, and sexual vitality in both men and women, and pomegranate for mitochondrial support. Graded honestly, most of that ingredient evidence is emerging rather than settled, and the finished-formula gene-expression claim is emerging -- so this supports the cell's Transform function and daytime vitality, it does not treat fatigue or any condition.
What it supports
- Supports cellular energy production and mitochondrial function
- Supports daytime physical vigor and stamina
- Supports mental acuity and everyday cognition
- Supports healthy libido and sexual vitality in men and women
Which function it supports
Ties to the cell's Transform function -- supporting youthful gene expression for cellular energy production (the mitochondria) across brain, heart, and skeletal muscle, and the daytime vitality that depends on it. NRF2/purification is R2 Night's role, not this one.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision US Supplement Facts image from the US product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed.
| Amount per 6 capsules | Amount | % DV |
|---|---|---|
| Calories | 10 | |
| Total Carbohydrates | 2 g | 1%** |
| Dietary Fiber | <1 g | 2%** |
| Protein | 1 g | |
| ageLOC Recharge BlendCordyceps Cs-4 mushroom mycelia (Paecilomyces hepiali), pomegranate (Punica granatum) fruit extract, Pharmanex Asian ginseng Rb1 (Panax ginseng) root extract | 2270 mg | * |
- Servings per container:
- 30
US panel. The only PIP linked from this product's page is the SINGAPORE edition (ageLOC-R2-PIP-SG.pdf, nuskin.com.sg in the footer), so the US Supplement Facts image is the source here. If a US PIP appears, re-verify against it.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performancePubMed
International Journal of Sport Nutrition and Exercise Metabolism · 2004
A randomized, placebo-controlled trial in trained cyclists found that five weeks of Cordyceps sinensis supplementation did not significantly improve aerobic capacity or endurance performance, an honest null finding in already well-trained athletes.
- Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation.PMC
3 weeks of mushroom blend (4g/day) improved VO2max (~10.9%) and time-to-exhaustion vs · 2017
In 28 young adults, a randomized placebo-controlled trial of a Cordyceps militaris mushroom blend showed no significant change after one week, and in the 10 continuing three weeks, maximal oxygen uptake improved.
- Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trialPubMed
Journal of Alternative and Complementary Medicine · 2010
Twelve weeks of Cs-4 Cordyceps sinensis raised the metabolic (ventilatory) threshold by about 10 percent in healthy older adults during exercise testing.
- Astragalus and Cordyceps Derivatives in the Treatment of Aging-Related Chronic Diseases and Neurodegenerative DisordersSource
2026
Astragalus and Cordyceps contain multiple bioactive constituents associated with antioxidant, anti-inflammatory, immunomodulatory, and organ-protective effects in experimental models.
- Cordyceps sinensis and Sonodynamic Therapy in Non-Small Cell Lung Cancer: Pharmacological Basis, Therapeutic Potential, and Future DirectionsPubMed
2026
A narrative review argued that water-based decoctions of a medicinal fungus carry inorganic arsenic at roughly four times the Chinese Pharmacopoeia limit, and proposed magnetic nanoparticles with focused ultrasound as a workaround.
- Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in DermatologyPubMed
Gels · 2025
This review summarized Cordyceps militaris compounds such as cordycepin reported to induce apoptosis against melanoma and to promote collagen synthesis, noting clinical trials are still needed.
Skeletal muscle mitochondrial-methylation-neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populationsEmergingExpert review2026
This review proposes an untested theoretical model integrating Cordyceps, betaine, and tyrosine for exercise performance; mechanistic and clinical evidence is needed to evaluate efficacy.
Chunhong Xu; Weilu Cai; Jing Li; Ying Ma
Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action.2026
A review found that Cordyceps species and their bioactive components, including cordycepin, showed anti-cancer activity in preclinical studies through apoptosis induction, cell-cycle arrest, and signaling pathway modulation.
Gunter NV; Ong YS; Lai ZW; Morita H; Chamyuang S; Owatworakit A; Mah SH -- Journal of Asian natural products research
Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin.2026
In diabetic mice and keratinocyte cell models, Cordyceps militaris extract accelerated wound closure and epidermal regeneration by restoring HIF-1alpha and TGF-beta1 expression and modulating SIRT1/Nrf2/HO-1 signaling.
Lin TK; Tsai CL; Tsai BC; Kuo CH; Ho TJ; Hsieh DJ; Kuo WW; Huang CY; Lee PY -- Life (Basel, Switzerland)
Nature's marvel: unravelling the multiphase composition of Cordyceps militaris mushroom and its implications as a dietary supplement.2026
A review characterizes the multiphase chemical composition of Cordyceps militaris mushroom, examining its profile as a dietary supplement ingredient.
Parthasarathy S; Tharumasivam SV; Aly SH; Giridharan B; Durairaj S; Elbadry AMM; El-Shazly M -- Journal of food science and technology
Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.2026
Cordyceps militaris strain KTDT8 produced the highest cordycepin, adenosine, and polysaccharide levels along with the strongest antioxidant activity, remaining genetically stable across four generations of cultivation.
Thi Gam D; Ngoc Minh T; Khac Hung N; Thuy Diep N; Thi Thuy T; Thi Dung K; Thi Thanh Ha D; Thi Phuong Doai N; Tien Phat D; Thi Huyen T; Huu Trung K -- Current drug metabolism
Medicinal Mushrooms and Their Bioactive Compounds: From Traditional Use to Therapeutic Potential.2026
Medicinal mushrooms including Cordyceps militaris, Ganoderma lucidum, and Grifola frondosa contain polysaccharides and triterpenoids studied for immune support, anti-inflammatory, antioxidant, antimicrobial, and anticancer bioactivity across preclinical and clinical research.
Sadowska A; Włosek-Pawełas D; Car H -- Molecules (Basel, Switzerland)
Comparative bioaccumulation and biotransformation of selenate, selenite, and selenomethionine in Cordyceps militaris.2026
Selenomethionine showed faster absorption than selenite or selenate in Cordyceps militaris mycelium, with sulfur, phosphorus, and methionine competitively reducing selenium uptake, identifying selenite as the optimal biofortification form.
Zhang Y; Hu T; Zhao B; Guo Y -- Biochemistry and biophysics reports
Preload time-dependent effects of Panax ginseng on postprandial glucose tolerance. A randomized controlled study in healthy middle-aged participantsEstablishedClinical trial2026
A crossover trial found Panax ginseng consumed 90 or 45 minutes before a carbohydrate meal reduced postprandial glucose and insulin peaks in healthy adults, but had no effect when taken immediately before eating.
Anne Nilsson
Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress VulnerabilityEmergingExpert review2026
Ginsenosides from Panax ginseng suppress FKBP51 expression, reducing stress sensitivity and supporting cognitive resilience during challenge through specific molecular pathway.
Paweł Hanus; Dorota Frydecka; Michał Ślęzak
Intervention of ginseng-derived macromolecular drugs in Alzheimer's disease: exploring mechanisms and assessing potentialEmergingExpert review2026
Ginseng polysaccharides inhibit amyloid-beta aggregation and suppress Notch signaling pathway-mediated neuroinflammation, reducing neuronal apoptosis in Alzheimer's disease models.
Weiqiao Liu; Yunfan Bai; Wenyi Qu; Xiaoying Zhang; Shuo Zhou; Haoming Luo; Ming Zhu; Dongyang Li; Xiaoxue Fang
Comparative Efficacy of Herbal Products on Metabolic Parameters in Metabolic-Dysfunction Associated Liver Disease: A Systematic Review and Network Meta-AnalysisEmergingExpert review2026
A network meta-analysis of 123 trials found herbal products like naringenin, Korean red ginseng, green tea, and sumac modestly improved triglycerides, glucose, and insulin resistance in MASLD, though evidence certainty was mostly low.
Revathi Thirumushi Sairaj; Alejandro Chen Liang; Yeison Cruz Castillo; Mariela Denise Fermin Madera; Jose Medina; Tatiana Alexandra Moreno Díaz; Gabriela Flores Monar; Supritha Chintamaneni; Camila Sanchez Cruz; Rashmi Advani; Sushovan Guha; Ernesto Calderón-Martinez
The dual role of metabolic reprogramming in macrophage polarization in rheumatoid arthritis and coronary heart disease and the intervention strategy of traditional Chinese medicineEmergingExpert review2026
A review found that shifting macrophage metabolism from glycolysis toward oxidative phosphorylation reduced inflammation in rheumatoid arthritis and coronary heart disease, and identified berberine and ginsenoside Rb1 as compounds that may rebalance this shift.
Haichun Zheng; Xiuyue Li; Jing Ru; Zhuoran Meng; Weibing Liu; Tao Jia; Shan Zhang; Qianwen Deng; Wenyi Huang; Renjie Dong; Qianrong Li
Liver Disease and Plant-Derived Phytoconstituents: From Ethnopharmacology to Modern MedicineEmergingExpert review2026
This review compiled evidence on plant-derived phytoconstituents such as silymarin, glycyrrhizin, curcumin, resveratrol, and ginsenosides as hepatoprotective agents across liver diseases, summarizing their mechanisms, pharmacokinetics, and regulatory status.
Bipindra Pandey; Sagun Kharel; Anjila Shrestha; Biswash Sapkota; Laxman Subedi; Sushil Panta
Microbiome-mediated pharmacology of ginseng: Mechanistic insights into metabolic regulation and therapeutic potentialEmergingExpert review2026
Ginseng remodels gut microbiota to produce bioavailable metabolites that enhance insulin sensitivity, suppress inflammation, and improve lipid metabolism in metabolic disorders including NAFLD.
Kang WK; Hwang SY; Kang H; Hyun JW; Kim SK; Lee MH -- Journal of ginseng research
Integrating multi-omics and network pharmacology in a systems approach: a mechanism study of ginseng-derived panaxadiol saponins against immune-mediated aplastic anemiaEmergingPrimary research (design unspecified)2027
Panaxadiol saponins partially restored hematopoiesis in immune-mediated aplastic anemia mice by suppressing NOD/NLRP3 inflammatory signaling and improving intestinal barrier integrity.
Ai Mi; Lichao Wu; Shiwen Wu; Wenjie Mi; Jinjian Lan; Ruilan Gao; Xiaoling Yu; Yanna Zhao; Hui Wang
The role of rare ginsenosides in the prevention and treatment of liver diseases.2026
A review found that rare ginsenosides from Panax ginseng have been studied for pharmacological effects relevant to liver injury and metabolic dysfunction, building on traditional use for liver-blood insufficiency.
Zhang Y; Liu Y; Wei Y; Ren Z; Jin YH; Li G -- Journal of ethnopharmacology
Ginsenoside RK3 attenuates isoproterenol-induced heart failure in mice through AMPK/Sirt1/PGC-1α pathway activationEmergingPrimary research (design unspecified)2026
Ginsenoside RK3 protected mouse hearts from isoproterenol-induced failure by activating AMPK/Sirt1/PGC-1alpha signaling and restoring tricarboxylic acid cycle metabolism.
Chongyang Zhang; Yuning Chen; Wei Liu; Rong-Chang Chen
Extraction, preparation, pharmacological activities, and potential applications of ginsenosides Rk1 and Rg5.2026
A review found that rare ginsenosides Rk1 and Rg5 from Panax species show antitumor, anti-inflammatory, and immunomodulatory activity, with ongoing work to improve their extraction and industrial production.
Jia W; Zhang H; Cheng J; Zhang X; Han C; He Y; Lu H; Liu H; Li C; Ma H; Xue P -- Journal of ethnopharmacology
Panax ginseng-Polygonum cuspidatum is beneficial for alleviating atherosclerosis in ApoE-/- mice by modulating the composition of gut microbiota and related metabolitesEmergingPrimary research (design unspecified)2026
In ApoE-knockout mice fed a high-fat diet, a Panax ginseng-Polygonum cuspidatum herbal combination reduced aortic atherosclerotic plaque and lipid levels, partly by reshaping gut microbiota composition and metabolites.
Ya Wang; Jinyi Fu; Jingyi Zhan; Yuanbin Liang; Ruofan Chen; Linjing Su; Qingbing Zhou; Ying Zhang; Weihong Cong; Fengqin Xu
Ginsenoside Rg3-enriched red ginseng extract mitigates sepsis by inhibiting platelet-leukocyte aggregates and regulates thrombo-inflammatory pathways.2026
In a mouse sepsis model, Rg3-enriched red ginseng extract reduced platelet-leukocyte aggregate formation and plasma tissue factor levels, though platelet factor 4 levels were not significantly changed.
Lee YY; Akram AW; Saba E; Chae HK; Seo MG; Kim SD; Park SJ; Kwak D; Rhee MH -- Journal of ginseng research
Evaluating the Hepatoprotective Effect of Phyllanthus emblica and Panax ginseng Powders on Acetaminophen-Induced Liver Fibrosis in a Rat ModelEmergingPrimary research (design unspecified)2026
Combined Phyllanthus emblica and Panax ginseng powders significantly attenuated acetaminophen-induced hepatic fibrosis and normalized liver enzymes in rats.
Fiza Javed; Nourah Harbi Almutairi; Wardha Tariq; Mah Noor; Shiza Javed; Usman Haider; Ghalia Shamlan; Gholamreza Abdi; Rana Muhammad Aadil
The role of ginseng and ginsenosides in ROS and cardiovascular disease.2026
Ginseng and ginsenosides such as Rg1, Rg3, and Rb1 regulate excess reactive oxygen species and restore antioxidant enzyme function, mechanisms studied for their relevance to cardiac oxidative damage.
Vijayakumar A; Park JH; Kim JH -- Journal of ginseng research
Ginsenosides remodel tumor immune microenvironment through metabolic reprogramming: Targets and mechanisms.2026
Ginsenosides reversed the Warburg effect and modulated fatty acid, cholesterol, amino acid, and nucleotide metabolism to restore immune cell function and limit tumor cell proliferation within the tumor microenvironment.
Yao ZW; Wang YQ; Zhu H -- Phytomedicine : international journal of phytotherapy and phytopharmacology
Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects.2026
Ginsenosides Rg1, Rb1, and Rg3 along with ginseng polysaccharides are reviewed as multitarget candidates that attenuate oxidative stress and preserve mitochondrial function relevant to ovarian aging and premature ovarian insufficiency.
Li YX; Zhong HZ; Wei SB -- Frontiers in pharmacology
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Fecal Calprotectinemerging evidence
via Pomegranate extract · 1 studies, 1 in people
A 12-week juice intervention with a modulatory effect on the relevant transcriptional profile.
What people often notice when this marker sits outside the usual range
Higher: Diarrhoea, often with urgency; blood or mucus in stool.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC R2 Day is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC R2 Day pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Energy & Mitochondria
For Mood & Hormones
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take six capsules in the morning, with or without food, and pair with R2 Night in the evening -- the two halves are designed to be used together. Follow the current label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC R2 DayThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC R2 is a two-part daily system built to support the cell's own renewal and energy pathways as we age. One part leans toward daytime purification support, the other toward overnight energy and renewal support. It fits people who want a thoughtfully timed longevity routine rather than one generic pill.
FAQ
What does ageLOC R2 support?
It supports the cell's natural renewal processes, the body's normal antioxidant defenses, healthy cellular energy production, and healthy cellular aging over time. It supports the body's own renewal; it does not reverse aging or reset genes.
How do I take it?
Take the daytime portion in the morning and the evening portion at night, each with water, following the pack layout. The morning-and-night rhythm is the whole point, so keep both consistent.
What makes it different?
It is two formulas timed to the body's day-and-night rhythm, aimed at supporting the cell's own maintenance machinery rather than a single all-day dose.