When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
This is genetic detox, done overnight -- two evening capsules of broccoli-seed sulforaphane, grape seed OPCs, and red orange. Instead of a cleanse that just flushes the gut, it works upstream at the gene level: it flips on NRF2, the switch that turns up your cells' own detox and glutathione genes, so your body clears the metabolic waste and byproducts that pile up through a normal day while you sleep -- and you wake up renewed. In Nu Skin's language this is 'cellular purification'; in plainer terms, it is your own detox machinery, turned up. Of the whole ageLOC line, this is the formula whose specific job is detox.
Why the evidence supports it
This is the one ageLOC product where NRF2 is genuinely the headline, and its own science says so: the R2 evening formula is built around cellular purification, and the studies Nu Skin cites for it are glutathione synthesis, autophagy, and the role of detoxification reactions in aging. The mechanism is clean -- broccoli-seed sulforaphane is the most-studied NRF2 activator there is, a compound that switches on NRF2 (a transcription factor, so this is a gene-expression event) to turn up the body's own phase-II detox and glutathione genes; human trials show oral sulforaphane raising those protective enzymes measurably. Grape seed OPCs and red orange add supporting antioxidant-gene activity. Kept honest: it supports your body's own purification machinery overnight -- it is not a cleanse, a chelator, or a treatment for any toxic condition.
What it supports
- Supports the cell's own overnight purification and renewal
- Supports the body's NRF2-driven phase-II detox and glutathione systems
- Helps the body neutralize and clear everyday cellular waste and byproducts
- Complements R2 Day -- purification by night, energy by day
Which function it supports
Ties to the cell's Adapt function -- activating NRF2, the gene switch that turns on the body's own phase-II detox and glutathione genes, so cells run their natural purification during the overnight repair window.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis
Life sciences · 2023
A meta-analysis of 25 animal studies found that sulforaphane treatment improved kidney function markers and reduced kidney fibrosis and scarring across various models of kidney disease in animals.
- Protective effects of sulforaphane against toxic substances and contaminants: A systematic review
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
A systematic review found sulforaphane from broccoli activates NRF2 across organs, most studied in liver and nerve tissue, easing inflammation and oxidative stress, but concluded that safe human dosing has not yet been established.
- Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
Oxidative Medicine and Cellular Longevity · 2016
This review compares sulforaphane to other plant-derived NRF2 activators like curcumin and resveratrol, concluding sulforaphane is among the most potent at inducing the body's cytoprotective Phase II gene program.
- KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
Seminars in Cancer Biology / PMC · 2016
This review explains how sulforaphane releases the NRF2 transcription factor from its KEAP1 anchor, allowing NRF2 to switch on genes for the body's Phase II detox and antioxidant enzymes.
- Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration
Nutrients · 2019
This pilot study found that commonly used acid-suppressing medications did not meaningfully change sulforaphane bioavailability from broccoli sprout extract in participants.
- A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation
Respiratory Research · 2016
In this human ozone-challenge study, oral sulforaphane from broccoli sprout homogenate did not measurably increase antioxidant gene expression or protect against airway inflammation, a useful null finding on dosing and context.
The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trialsEstablishedMeta-analysis2021
A systematic review and meta-analysis of controlled human trials found grape seed extract supplementation shifted markers of oxidative stress and inflammation, supporting that the OPCs/proanthocyanidins in R2 Night measurably reinforce the body's antioxidant balance in people.
Foshati S; Rouhani MH; Amani R -- International journal of clinical practice
Short-Term Effects of Broccoli-Derived Glucoraphanin on Recovery from Eccentric Muscle Damage: A Double-Blind Randomized Crossover StudyEstablishedRandomized controlled trial2026
In a small randomized crossover trial, short-term broccoli glucoraphanin supplementation before eccentric exercise did not significantly affect muscle strength, soreness, creatine kinase, or recovery compared to placebo.
Cesanelli L; Thomas R; Mickevičius M; Sniečkus A; Mickevičienė D; Venckūnas T; Stasiulis A; Kamandulis S -- Nutrients
Grape Seed Components as Protectors of Inflammation, DNA Damage, and CancerEmergingExpert review2023
A review of grape seed proanthocyanidins summarizes their pleiotropic antioxidant actions, including protection of DNA from oxidative damage, framing the R2 Night OPCs as broad-spectrum reinforcement of the body's antioxidant and genome-protective defenses.
Mancini M; Cerny MEV; Cardoso NS; Verissimo G; Maluf SW -- Current nutrition reports
The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A ReviewEmergingExpert review2023
A review documents that NRF2 is a master transcription factor directly or indirectly regulating more than 2,000 genes, the genetic basis for why converging multiple NRF2 activators -- sulforaphane, grape seed OPCs and pomegranate polyphenols in R2 Night -- acts as a single powerful lever on the body's antioxidant and detox gene network.
McCord JM; Gao B; Hybertson BM -- Antioxidants (Basel, Switzerland)
Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson's disease: A reviewEmergingExpert review2022
A mechanistic review describes how ellagic acid, the pomegranate polyphenol upstream of urolithin A, activates the Keap1-NRF2-ARE pathway, supporting that the R2 Night pomegranate fraction feeds into the body's core NRF2 antioxidant-gene response.
Wang Q; Botchway BOA; Zhang Y; Liu X -- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagyEmergingPrimary research (design unspecified)2022
Urolithin A protected human skin fibroblasts from UVA-driven photoaging through NRF2 activation and mitophagy, directly linking the R2 Night pomegranate metabolite to the same NRF2 antioxidant-gene switch plus mitochondrial cleanup -- a skin-aging-relevant mechanism.
Liu W; Yan F; Xu Z; Chen Q; Ren J; Wang Q; Chen L; Ying J; Liu Z; Zhao J; Qiu J; Zhang C; Jiang M; Xiang L -- Journal of photochemistry and photobiology. B, Biology
Grape seed proanthocyanins protect fluoride-induced hepatotoxicity via the Nrf2 signaling pathway in male ratsEmergingAnimal study2024
Grape seed proanthocyanidins were shown to act through the NRF2 signaling pathway to strengthen liver antioxidant defenses under chemical stress, indicating the OPCs in R2 Night can engage the same NRF2 antioxidant-gene program as the sulforaphane active.
Wei R; Ping GF; Lang ZT; Wang EH -- Toxicology research
Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2EmergingAnimal study2022
In mice, intraperitoneal urolithin A activated Nrf2/ARE antioxidant signaling and mitophagy in the liver and protected against acetaminophen-induced injury, though this used injected doses, not oral supplementation.
Gao Z; Yi W; Tang J; Sun Y; Huang J; Lan T; Dai X; Xu S; Jin ZG; Wu X -- International journal of biological sciences
Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D-galactose-induced aging mouse model by modulating the gut microbiotaEmergingAnimal study2022
Grape seed proanthocyanidin extract lowered oxidative-stress and inflammation markers in an aging model, consistent with the OPC fraction in R2 Night supporting the body's own antioxidant defenses during age-related redox decline.
Sheng K; Yang J; Xu Y; Kong X; Wang J; Wang Y -- Food & function
Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathwayEmergingCell-culture study2024
In a cell model, procyanidin (a grape seed OPC) reduced oxidative and inflammatory stress via the NRF2/HO-1 pathway, showing the R2 Night proanthocyanidins converge on the same NRF2 -> HO-1 antioxidant-gene axis as its other actives.
Zeng J; Weng Y; Lai T; Chen L; Li Y; Huang Q; Zhong S; Wan S; Luo L -- Naunyn-Schmiedeberg's archives of pharmacology
Protective effects of sulforaphane against toxic substances and contaminants: A systematic reviewEstablishedSystematic review2024
A systematic review found sulforaphane from broccoli activates NRF2 across organs, most studied in liver and nerve tissue, easing inflammation and oxidative stress, but concluded that safe human dosing has not yet been established.
Cascajosa-Lira A; Prieto AI; Pichardo S; Jos A; Cameán AM -- Phytomedicine : international journal of phytotherapy and phytopharmacology
Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysisEstablishedMeta-analysis2023
A meta-analysis of 25 animal studies found that sulforaphane treatment improved kidney function markers and reduced kidney fibrosis and scarring across various models of kidney disease in animals.
Monteiro EB; Ajackson M; Stockler-Pinto MB; Guebre-Egziabher F; Daleprane JB; Soulage CO -- Life sciences
The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic RhinitisEstablishedRandomized controlled trial2021
In 47 adults with grass pollen allergic rhinitis, adding broccoli sprout extract to a nasal steroid spray improved nasal airflow more than the steroid alone, though nasal cytokine levels did not change significantly.
Yusin J; Wang V; Henning SM; Yang J; Tseng CH; Thames G; Arnold I; Heber D; Lee RP; Sanavio L; Pan Y; Qin T; Li Z -- Nutrients
Sulforaphane Synergies with Phytochemicals and Pharmaceuticals: Implications for HealthspanEmergingExpert review2026
Published research documents sulforaphane synergies with cancer drugs and phytochemicals that enhanced efficacy, reduced dosages, and mitigated cardiac toxicity.
Jed W Fahey; Hua Liu
Sulforaphane in Cancer Prevention and Therapy: A State-of-the-Art Review of Epidemiological Evidence, Molecular Mechanisms, and Translational ChallengesEmergingExpert review2026
A review reports that sulforaphane from broccoli affects cancer-related cell pathways including Nrf2 and cell death, and that human trials have lowered carcinogen biomarker levels, though poor bioavailability still limits its clinical use.
Jang JY; Kim D; Lee NK; Im E; Kim ND -- International journal of molecular sciences
Sulforaphane in Cutaneous Disorders and Skin Injury: Mechanisms, Evidence, and Clinical PerspectivesEmergingExpert review2026
This review reports sulforaphane, an isothiocyanate from broccoli, acts through the Keap1/NRF2 pathway to reduce oxidative stress and inflammation in skin conditions, but concludes robust human evidence is still lacking for chronic diseases like psoriasis and eczema.
Hua Liu; Claire Y Shi; Jed W Fahey
The Chemopreventive and Anticancer Potential of Glucosinolates and Their Hydrolysis Products from Cruciferous VegetablesEmergingExpert review2026
A review reports that glucosinolates in cruciferous vegetables break down into sulforaphane and related compounds that activate the body's Nrf2 detox pathway in humans, though larger standardized trials are still needed to confirm effective doses.
Labudda M; Rybarczyk-Płońska A; Sobieszek KA; Niedziński T; Wurlitzer WB; Muszyńska E; Prabucka B; Florczak S; Tomczykowa M; Makowski W; Graska J; Frankowski J; Kęszycka P; Gajewska D; Dababat AA; Morkunas I; Trafiałek J; Tomczyk M; Czapla M -- Nutrients
Targeting Glyoxalase-1 Pathway with Natural Compounds: A Translational Strategy to Reduce Dicarbonyl Stress and Prevent Chronic DiseasesEmergingExpert review2026
In a review, compounds including sulforaphane, resveratrol, alpha-lipoic acid, selenium, vitamin D3 and N-acetylcysteine were linked to increased Glyoxalase-1 activity, which helps clear the reactive byproduct methylglyoxal implicated in glycation-related disease.
Masood Alam Khan; Hina Younus
Bioactive sulforaphane from cruciferous vegetables: advances in biosynthesis, metabolism, bioavailability, delivery, health benefits, and applicationsEmergingExpert review2025
A review covers a decade of research on sulforaphane from cruciferous vegetables, describing how gut bacteria release it from glucosinolates and how it is quickly metabolized and excreted through the mercapturic acid pathway.
Zhang Y; Zhang W; Zhao Y; Peng R; Zhang Z; Xu Z; Simal-Gandara J; Yang H; Deng J -- Critical reviews in food science and nutrition
Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translationEmergingExpert review2025
Sulforaphane acts through multiple pathways including Nrf2 activation, histone deacetylase inhibition, and ferroptosis induction in cancer models.
Zhipeng Zhao; Qianyue Chen; Xinyu Qiao; Jianjiang Wang; Zaid Tala Abdulqader Ali; Jun Li; Ling Yin
Effects of the Pharmacological Modulation of NRF2 in Cancer ProgressionEmergingExpert review2025
A review explained that NRF2, a cell stress-response gene, can either suppress or promote cancer spread depending on cancer stage, and discussed drugs like sulforaphane that activate it versus others that block it.
Gelerstein-Claro S; Méndez-Valdés G; Rodrigo R -- Medicina (Kaunas, Lithuania)
Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment OutcomesEmergingExpert review2025
A review reported that curcumin, resveratrol, sulforaphane, N-acetylcysteine and molecular hydrogen act on NF-kB and Nrf2 redox pathways in rheumatoid arthritis, with no standardized dosing or long term safety data.
Bilski R; Nuszkiewicz J -- International journal of molecular sciences
Glucosinolates and Their Hydrolytic Derivatives: Promising Phytochemicals With Anticancer PotentialEmergingExpert review2025
A review summarizes animal studies showing that sulforaphane, phenethyl isothiocyanate, and related plant compounds from cruciferous vegetables affect cancer cell survival pathways, with good bioavailability and low toxicity reported across the studies covered.
Joković N; Pešić S; Vitorović J; Bogdanović A; Sharifi-Rad J; Calina D -- Phytotherapy research : PTR
Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific DisordersEmergingExpert review2025
Sulforaphane from broccoli seeds and sprouts crossed the blood-brain barrier and supported mitochondrial function and neuroprotection.
Jed W Fahey; Hua Liu; Holly Batt; Anita A Panjwani; Petra Tsuji
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC R2 Night is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC R2 Night pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Detox
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take two capsules in the evening, with or without food, alongside R2 Day in the morning. Follow the current label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC R2 NightThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.