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What it is
This is genetic detox, done overnight -- two evening capsules of broccoli-seed sulforaphane, grape seed OPCs, and red orange. Instead of a cleanse that just flushes the gut, it works upstream at the gene level: it flips on NRF2, the switch that turns up your cells' own detox and glutathione genes, so your body clears the metabolic waste and byproducts that pile up through a normal day while you sleep -- and you wake up renewed. In Nu Skin's language this is 'cellular purification'; in plainer terms, it is your own detox machinery, turned up. Of the whole ageLOC line, this is the formula whose specific job is detox.
Why the evidence supports it
This is the one ageLOC product where NRF2 is genuinely the headline, and its own science says so: the R2 evening formula is built around cellular purification, and the studies Nu Skin cites for it are glutathione synthesis, autophagy, and the role of detoxification reactions in aging. The mechanism is clean -- broccoli-seed sulforaphane is the most-studied NRF2 activator there is, a compound that switches on NRF2 (a transcription factor, so this is a gene-expression event) to turn up the body's own phase-II detox and glutathione genes; human trials show oral sulforaphane raising those protective enzymes measurably. Grape seed OPCs and red orange add supporting antioxidant-gene activity. Kept honest: it supports your body's own purification machinery overnight -- it is not a cleanse, a chelator, or a treatment for any toxic condition.
What it supports
- Supports the cell's own overnight purification and renewal
- Supports the body's NRF2-driven phase-II detox and glutathione systems
- Helps the body neutralize and clear everyday cellular waste and byproducts
- Complements R2 Day -- purification by night, energy by day
Which function it supports
Ties to the cell's Adapt function -- activating NRF2, the gene switch that turns on the body's own phase-II detox and glutathione genes, so cells run their natural purification during the overnight repair window.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision US Supplement Facts image from the US product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed.
| Amount per 2 capsules | Amount | % DV |
|---|---|---|
| ageLOC Renew BlendGrape (Vitis vinifera L.) seed extract, red orange (Citrus sinensis) fruit extract, broccoli (Brassica oleracea italica) seed extract | 450 mg | * |
- Servings per container:
- 30
- Other ingredients:
- Capsule (gelatin), microcrystalline cellulose, stearic acid, silicon dioxide.
US panel, and it MATCHES the Singapore PIP's figures (450 mg Renew Blend, same three extracts) -- checked because the SG PIP was the only one linked from the page.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Efficacy and safety of sulforaphane in schizophrenia: a systematic review and meta-analysis of randomized controlled trialsPubMed
BMC psychiatry · 2025
A meta-analysis of four randomized trials (369 schizophrenia patients) found sulforaphane modestly improved negative symptoms at 12 weeks and general psychopathology, with no cognitive benefit and no significant change in PANSS total scores.
- Investigating the clinical efficacy, safety and molecular mechanism of sulforaphane in autism spectrum disorder: an integrated study combining meta-analysis, network pharmacology, and computational biologyPubMed
2025
Sulforaphane supplementation for 4-10 weeks reduced social responsiveness scale scores in autism spectrum disorder compared to placebo without significant adverse effects.
- Dietary sulforaphane in cancer chemoprevention: epigenetic regulation and PRMT5-MEP50 complex inhibition-a systematic reviewPubMed
2026
This systematic review of 118 studies found a phase II trial in which 12 months of sulforaphane supplementation reduced bronchial Ki-67 proliferation by 20% in high-risk former smokers, versus a 65% increase with placebo.
- Protective effects of sulforaphane against toxic substances and contaminants: A systematic reviewPubMed
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
A systematic review found sulforaphane from broccoli activates NRF2 across organs, most studied in liver and nerve tissue, easing inflammation and oxidative stress, but concluded that safe human dosing has not yet been established.
- Efficacy and tolerability of sulforaphane in the therapeutic management of cancers: a systematic review of randomized controlled trialsPubMed
2023
Systematic review of eight randomized trials found sulforaphane significantly altered some cancer biomarkers while leaving others unchanged, with inconsistent PSA results across prostate cancer studies.
- Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?PubMed
Oxidative Medicine and Cellular Longevity · 2016
This review compares sulforaphane to other plant-derived NRF2 activators like curcumin and resveratrol, concluding sulforaphane is among the most potent at inducing the body's cytoprotective Phase II gene program.
Short-Term Effects of Broccoli-Derived Glucoraphanin on Recovery from Eccentric Muscle Damage: A Double-Blind Randomized Crossover StudyEstablishedRandomized controlled trial2026
In a small randomized crossover trial, short-term broccoli glucoraphanin supplementation before eccentric exercise did not significantly affect muscle strength, soreness, creatine kinase, or recovery compared to placebo.
Cesanelli L; Thomas R; Mickevičius M; Sniečkus A; Mickevičienė D; Venckūnas T; Stasiulis A; Kamandulis S -- Nutrients
Dietary sulforaphane in cancer chemoprevention: epigenetic regulation and PRMT5-MEP50 complex inhibition-a systematic reviewEstablishedSystematic review2026
This systematic review of 118 studies found a phase II trial in which 12 months of sulforaphane supplementation reduced bronchial Ki-67 proliferation by 20% in high-risk former smokers, versus a 65% increase with placebo.
Ping Yan; Changfeng Sun; Cunliang Deng
Effect of Glucoraphanin on the Abundance of Nrf2 Regulated Genes Within Circulating Small Extracellular Vesicles: A Pilot Dietary InterventionEstablishedRandomized controlled trial2026
Glucoraphanin-rich broccoli soup increased urinary sulforaphane but did not alter Nrf2-regulated genes within circulating small extracellular vesicles in healthy adults.
Nishantika Mitra; Mark H Vickers; Fiona E Lithander; Anastasiia Artuyants; Cherie Blenkiron; Meika Foster; Hui Hui Phua; Chris Pook; Zeke Wang; Richard F Mithen; Farha Ramzan
Proof of Principle: Short-Term Sulforaphane Precursor Intake Alters Selected Circulating Oxidative Stress and Muscle Damage Biomarkers Following Maximal Exercise: A Double-Blind Crossover TrialEstablishedClinical trial2026
Sulforaphane precursor supplementation for two weeks reduced exercise-induced muscle damage markers creatine kinase and myoglobin without altering endurance capacity in healthy adults.
Ruheea Taskin Ruhee; Shiori Wakasugi-Onogi; Sihui Ma; Nobuhiro Nakamura; Yasuhiro Seki; Katsuhiko Suzuki
Sulforaphane and Broccoli-Derived Preparations in Obesity and Obesity-Related Metabolic Dysfunction: Mechanistic Insights, Preclinical Evidence, and Clinical PerspectivesEmergingExpert review2026
This narrative review found strong preclinical evidence that sulforaphane improves obesity-related metabolic dysfunction via Nrf2 and AMPK pathways, though human trials show only limited, inconsistent metabolic benefits without confirmed weight loss.
Efthymios Poulios; Sousana K Papadopoulou; Evmorfia Psara; Dimitrios Tasoulas; Constantinos Giaginis
Food-Derived Natural Compounds as Molecular Targets in Cancer PreventionEmergingExpert review2026
This systematic review found food-derived compounds including polyphenols, organosulfur compounds, and sulforaphane inhibit cancer-related PI3K/Akt, NF-κB, and STAT3 signaling, though clinical translation remains limited by low bioavailability.
Megha Udayasankaran; Bhanu Shankar; Cheran Radhakrishnan; Sundar Raj Moorthy; Ramachandran Samivel; Ramachandran Vinayagam; Dhanavathy Gnanasampanthapandian; Kanagaraj Palaniyandi
Natural Products in Prostate Cancer: Crosstalk Among the Gut Microbiome, Androgen Receptor Signaling, and Epigenetic RegulationEmergingExpert review2026
Natural products including sulforaphane modulate interconnected pathways in prostate cancer through Nrf2 activation, oxidative stress reduction, and epigenetic regulation.
Mohammad Muzaffar Mir; Javed Iqbal Wani; Rashid Mir; Muffarah Hamid Alharthi; Abdullah Ayed; Partha Nandi; Ayyub Ali Patel; Ayaz Khurram Mallick; Mohannad Mohammad S Alamri; Mohammed O'haj; Tarig Babikir Algak Khalid; Adnan Jehangir; Hany M A Sonpol; Ahmed Mussad Senbel
Organosulfur compounds as dual-action agents: a critical review of antimicrobial and immunomodulatory potentials, and translational barriersEmergingExpert review2026
This critical review found sulforaphane has the strongest human pharmacokinetic data among organosulfur compounds, while unstable allicin is seldom detectable in vivo, and controlled clinical trials of infection outcomes are still lacking.
Victor Uchenna Chigozie; Lilian Nwanneka Ebenyi; Charles Okechukwu Esimone
Natural compounds as epigenetic modulators in gynaecological cancers: From chemoresistance to precision oncologyEmergingExpert review2026
Phytochemicals including curcumin and sulforaphane modulate DNA methyltransferases and histone deacetylases in gynecological cancer models, though clinical validation remains insufficient.
Lingasamy P; Kiruba B; Rajakumar S; Surisetti SM; Patel N; Lulu S S; Salumets A; Modhukur V -- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
A Holistic Omics-Based Overview of Postharvest Wound Response and Mineral Dynamics in Broccoli Stalks During the Self-Adaptive StageEmergingPrimary research (design unspecified)2026
Multi-omics profiling of wounded broccoli stalks found rapid transcriptional and metabolic reprogramming within 3 hours post-harvest, including transient iron and potassium surges and sulforaphane accumulation at the wound site.
Aqleem Abbas; Ni Heng Jia; Yanyin Guo; Muhammad Asim; Mingkun Jiang
NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions.2026
An analysis of over 2,000 lung cancer patients found that higher tumor NRF2 pathway activation, the same antioxidant-defense pathway induced by sulforaphane, was associated with worse survival outcomes.
Ungvari Z; Menyhart O; Lehoczki A; Fekete M; Fazekas-Pongor V; Ocana A; Varga P; Győrffy B -- GeroScience
Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2EmergingPrimary research (design unspecified)2026
Sulforaphane reduced cisplatin-induced kidney injury markers, inflammation, apoptosis, and oxidative stress in mice and cultured kidney cells by activating the NRF2 pathway.
Zeyu Wu; Mengting Lu; Lei Xu; Ming Luo; Limei Shan; Hongxia Xing; Wenwen Li; Junling Qian
Influence of plant-derived bioactive compounds on iron metabolism: mechanistic insights with translational relevance.2026
A review found that plant-derived bioactive compounds can modulate iron-regulatory proteins including hepcidin, ferroportin, ferritin, and DMT1, influencing iron absorption and homeostasis through antioxidant-related mechanisms.
Freitas SML; Menezes MCDS; Lazarone Soares C; Batista MDS; da Costa DCF; Omena J; Citelli M -- Critical reviews in food science and nutrition
Elucidation of Sulforaphane-Mediated Effects on the Cellular Human Metabolome Using Metabolic ProfilingEmergingPrimary research (design unspecified)2026
Sulforaphane altered primary metabolic pathways in hepatoblastoma cells including the tricarboxylic acid cycle, urea cycle, glycolysis, and significantly elevated glutathione levels.
Nadine Bieß; Hans-Ulrich Humpf; Matthias Behrens; Andrea Gerdemann
NRF2 at the crossroads of Parkinson's disease and aging: Mechanistic insights and translational perspectives.2026
A review found that NRF2 signaling regulates antioxidant defenses and mitochondrial integrity in Parkinson's disease, with NRF2 deficiency accelerating neurodegeneration in preclinical models and pharmacological activators showing neuroprotective potential.
García-Yagüe AJ; Esteras N; Dinkova-Kostova AT; Rojo AI; Shiels PG; Dinnyes A; Tamas V; van Goor H; Lastres-Becker I -- Free radical biology & medicine
Sulforaphane improves exercise-induced NRF2 signaling in older adults: an in vivo-ex vivo approachEmergingPrimary research (design unspecified)2026
Combined sulforaphane treatment and acute exercise induced greater NRF2 activation and antioxidant gene expression in PBMCs from older adults than either intervention alone.
Dominick J Rodriguez; Ethan L Ostrom; Connor Chassman; Jay Robertson; Vincent Pan; Robert Buscaglia; Aimee L Eggler; Tinna Traustadóttir
Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study.2026
Adding mustard seed myrosinase to broccoli seed extract roughly doubled sulforaphane bioavailability in a randomized crossover trial compared to broccoli extract alone, based on urinary metabolite measurement.
Mastaloudis A; Holcomb L; Fahey JW; Sakaguchi CA; Nieman DC; Kay C; O'Donnell R; Pecorelli A; Kinney M; Li Y; Ishaq SL; Valacchi G -- Scientific reports
Targeted activation of Nrf2 via sulforaphane-loaded exosomes attenuated azoospermic condition in the rat modelEmergingPrimary research (design unspecified)2026
Exosome-delivered sulforaphane restored spermatogenesis and normalized Nrf2/autophagy signaling in chemotherapy-induced azoospermic rats more effectively than sulforaphane or exosomes alone.
Shahin Ahmadian; Mehrsa Fajri; Bernard A J Roelen; Ali Abedelahi; Mehdi Talebi; Reza Rahbarghazi; Mahdi Mahdipour
Bioaccessible sulforaphane attenuates oxidative stress-driven parainflammation in intestinal epithelial cells.2026
Bioaccessible sulforaphane from a broccoli stalk ingredient reduced COX-2 and inflammatory prostaglandin markers in intestinal epithelial cells, addressing oxidative-stress-driven parainflammation linked to metabolic disease and aging.
Medrano-Padial C; Medina S; García-Viguera C; Domínguez-Perles R -- Food & function
Exploring the anti-inflammatory activity of sulforaphane metabolitesEmergingPrimary research (design unspecified)2026
Sulforaphane and its metabolites reduced TLR4 and NLRP3 inflammasome activation and pro-inflammatory cytokine production through NF-κB suppression pathways.
Pagliarani B; Pruccoli L; Chemello C; Zusso M; Fonseca Moreira JC; Tarozzi A; Gomes HM -- Pharmacological reports : PR
Enhancing antioxidant capacity via NRF2 pathway activation to mitigate heat stress-induced oxidative damage in bovine granulosa cells, oocytes, and embryos.2026
In bovine granulosa cells and oocytes exposed to heat stress, the antioxidants quercetin and sulforaphane activated NRF2 signaling, cut oxidative damage, and increased the proportion of oocytes reaching the blastocyst stage.
Ramírez GG; Gad A; Menjivar NG; Burlingham S; Cheng MH; Chen TW; Ghosh S; Tesfaye D -- Frontiers in cell and developmental biology
Sulforaphane attenuates DSS-induced ulcerative colitis via the Nrf2/STAT3 signaling pathway and gut microbiota modulationEmergingPrimary research (design unspecified)2026
Sulforaphane attenuated ulcerative colitis symptoms in mice via Nrf2/STAT3 signaling pathway activation and beneficial gut microbiota modulation.
Mengyuan Chen; Gejun Yu; Wentao Wu; Peng Lei; Xiaohong Zhang; Jingyi Ren; Xiaoxin Jiang; Mengjie Yang; Canxia He; Canxia He
The H2S donor sulforaphane inhibits NLRP3 inflammasome activation by inducing mitochondrial autophagy and mitigating CBS-H2S axis damage in in-vitro and in-vivo models of Parkinson's disease.2026
In Parkinson's disease models, the H2S donor sulforaphane activated the CBS-H2S axis, promoted mitochondrial autophagy, reduced mitochondrial ROS, and inhibited NLRP3 inflammasome activation, improving motor performance and dopaminergic neuron survival in mice.
Xie W; Wu K; Zhang L; Feng X; Yang S; Jia S; Li Y; Wang X -- Bioorganic chemistry
Genetic and pharmacologic modulations elucidate NRF2 protective role in acute pancreatitisEmergingPrimary research (design unspecified)2026
Pharmacologic Nrf2 activation with sulforaphane reduced oxidative stress, inflammation, and severity of acute pancreatitis in experimental models.
Olga A Mareninova; Alex G Chang; Sebastian Hernandez Malpica; Jerik A Pineda; Rami Mamita; Natalia Shalbueva; Ilya Gukovsky; Anna S Gukovskaya
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC R2 Night is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC R2 Night pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
Ready-made stacks it is part of
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take two capsules in the evening, with or without food, alongside R2 Day in the morning. Follow the current label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC R2 NightThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC R2 Night is the evening half of the R2 pair -- two capsules of broccoli-seed sulforaphane, grape seed OPCs and red orange, taken before bed. Rather than flushing anything, it works upstream at NRF2, the gene switch that turns on your own cleanup and antioxidant machinery. It suits someone who wants overnight support for the body's own detoxification rather than a cleanse.
FAQ
What does ageLOC R2 Night support?
It supports the body's own detoxification and antioxidant pathways through NRF2 signalling, and supports the normal overnight cellular cleanup that happens while you sleep.
How do I take it?
Take the evening serving before bed, per the label. It is designed as the night half of a day-and-night pair, so it is usually taken alongside the daytime formula.
What makes it different?
It works on a gene switch rather than on the gut. Sulforaphane from broccoli seed is one of the best-studied NRF2 activators there is, and pairing it with grape seed OPCs and red orange targets the body's own systems instead of pushing anything through.