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$100.00 save $19.00 -- applied automatically through this link
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
This is genetic detox, done overnight -- two evening capsules of broccoli-seed sulforaphane, grape seed OPCs, and red orange. Instead of a cleanse that just flushes the gut, it works upstream at the gene level: it flips on NRF2, the switch that turns up your cells' own detox and glutathione genes, so your body clears the metabolic waste and byproducts that pile up through a normal day while you sleep -- and you wake up renewed. In Nu Skin's language this is 'cellular purification'; in plainer terms, it is your own detox machinery, turned up. Of the whole ageLOC line, this is the formula whose specific job is detox.
Why the evidence supports it
This is the one ageLOC product where NRF2 is genuinely the headline, and its own science says so: the R2 evening formula is built around cellular purification, and the studies Nu Skin cites for it are glutathione synthesis, autophagy, and the role of detoxification reactions in aging. The mechanism is clean -- broccoli-seed sulforaphane is the most-studied NRF2 activator there is, a compound that switches on NRF2 (a transcription factor, so this is a gene-expression event) to turn up the body's own phase-II detox and glutathione genes; human trials show oral sulforaphane raising those protective enzymes measurably. Grape seed OPCs and red orange add supporting antioxidant-gene activity. Kept honest: it supports your body's own purification machinery overnight -- it is not a cleanse, a chelator, or a treatment for any toxic condition.
What it supports
- Supports the cell's own overnight purification and renewal
- Supports the body's NRF2-driven phase-II detox and glutathione systems
- Helps the body neutralize and clear everyday cellular waste and byproducts
- Complements R2 Day -- purification by night, energy by day
Which function it supports
Ties to the cell's Adapt function -- activating NRF2, the gene switch that turns on the body's own phase-II detox and glutathione genes, so cells run their natural purification during the overnight repair window.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision US Supplement Facts image from the US product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed.
| Amount per 2 capsules | Amount | % DV |
|---|---|---|
| ageLOC Renew BlendGrape (Vitis vinifera L.) seed extract, red orange (Citrus sinensis) fruit extract, broccoli (Brassica oleracea italica) seed extract | 450 mg | * |
- Servings per container:
- 30
- Other ingredients:
- Capsule (gelatin), microcrystalline cellulose, stearic acid, silicon dioxide.
US panel, and it MATCHES the Singapore PIP's figures (450 mg Renew Blend, same three extracts) -- checked because the SG PIP was the only one linked from the page.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC R2 Night is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC R2 Night pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take two capsules in the evening, with or without food, alongside R2 Day in the morning. Follow the current label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC R2 NightThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC R2 Night is the evening half of the R2 pair -- two capsules of broccoli-seed sulforaphane, grape seed OPCs and red orange, taken before bed. Rather than flushing anything, it works upstream at NRF2, the gene switch that turns on your own cleanup and antioxidant machinery. It suits someone who wants overnight support for the body's own detoxification rather than a cleanse.
FAQ
What does ageLOC R2 Night support?
It supports the body's own detoxification and antioxidant pathways through NRF2 signalling, and supports the normal overnight cellular cleanup that happens while you sleep.
How do I take it?
Take the evening serving before bed, per the label. It is designed as the night half of a day-and-night pair, so it is usually taken alongside the daytime formula.
What makes it different?
It works on a gene switch rather than on the gut. Sulforaphane from broccoli seed is one of the best-studied NRF2 activators there is, and pairing it with grape seed OPCs and red orange targets the body's own systems instead of pushing anything through.