When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
This is the daytime engine of ageLOC R2 -- six morning capsules of cordyceps Cs-4, Panax ginseng, and pomegranate that work the epigenetics of energy. R2 is a two-part system: R2 Night runs the overnight genetic detox, and R2 Day targets the other side -- the gene-expression patterns behind cellular ENERGY production, right where the mitochondria turn food into usable fuel. The daytime vitality that rides on that engine is the point: physical vigor, mental acuity, and sexual health.
Why the evidence supports it
The honest frame, straight from the product's own science, is energy -- not detox (that is R2 Night's job). The ageLOC method behind R2 compared age-related gene-expression patterns and screened natural compounds for the ones that shifted the cellular-energy pattern toward a more youthful state, selecting cordyceps, ginseng, and pomegranate on that basis -- and the ageLOC Vitality research it grew from mapped that gene modulation across three tissues at once: brain, heart, and skeletal muscle (the specific gene count is Nu Skin's own figure). Each ingredient carries its own human evidence for that daytime story: cordyceps Cs-4 for exercise capacity and oxygen use (VO2max), Panax ginseng for energy and fatigue, mental acuity, and sexual vitality in both men and women, and pomegranate for mitochondrial support. Graded honestly, most of that ingredient evidence is emerging rather than settled, and the finished-formula gene-expression claim is emerging -- so this supports the cell's Transform function and daytime vitality, it does not treat fatigue or any condition.
What it supports
- Supports cellular energy production and mitochondrial function
- Supports daytime physical vigor and stamina
- Supports mental acuity and everyday cognition
- Supports healthy libido and sexual vitality in men and women
Which function it supports
Ties to the cell's Transform function -- supporting youthful gene expression for cellular energy production (the mitochondria) across brain, heart, and skeletal muscle, and the daytime vitality that depends on it. NRF2/purification is R2 Night's role, not this one.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance
International Journal of Sport Nutrition and Exercise Metabolism · 2004
A randomized, placebo-controlled trial in trained cyclists found that five weeks of Cordyceps sinensis supplementation did not significantly improve aerobic capacity or endurance performance, an honest null finding in already well-trained athletes.
- Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation.
3 weeks of mushroom blend (4g/day) improved VO2max (~10.9%) and time-to-exhaustion vs
In 28 young adults, a randomized placebo-controlled trial of a Cordyceps militaris mushroom blend showed no significant change after one week, and in the 10 continuing three weeks, maximal oxygen uptake improved.
- Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial
Journal of Alternative and Complementary Medicine · 2010
Twelve weeks of Cs-4 Cordyceps sinensis raised the metabolic (ventilatory) threshold by about 10 percent in healthy older adults during exercise testing.
- The effect of Panax ginseng supplementation on markers of resistance exercise-induced muscle damage: a systematic review
The Journal of sports medicine and physical fitness · 2024
A PRISMA systematic review of RCTs found Panax ginseng may reduce markers of resistance-exercise-induced muscle damage, supporting a recovery/vigor role while calling for larger trials.
- Panax ginseng and aging related disorders: A systematic review
Experimental gerontology · 2022
PRECLINICAL/REVIEW: A systematic review summarizes evidence that Panax ginseng supports mitochondrial and antioxidant function in aging-related models, an area still lacking direct human bioenergetic trials.
- Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for Fatigue
Frontiers in pharmacology · 2020
A systematic review of clinical and preclinical studies concluded Panax ginseng and its ginsenosides show a consistent anti-fatigue signal, while noting variable trial quality.
The effect of Panax ginseng supplementation on markers of resistance exercise-induced muscle damage: a systematic reviewEmergingSystematic review2024
A PRISMA systematic review of RCTs found Panax ginseng may reduce markers of resistance-exercise-induced muscle damage, supporting a recovery/vigor role while calling for larger trials.
Morgans R; Scholten JS; Rhodes D; Ceylan HI; Ryan B; Oliveira R; Clifford T -- The Journal of sports medicine and physical fitness
Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational UseEmergingMeta-analysis2023
A systematic review and meta-analysis of dietary supplements for erectile dysfunction identified Panax ginseng among the better-supported single ingredients, though evidence quality was mixed.
Petre GC; Francini-Pesenti F; Vitagliano A; Grande G; Ferlin A; Garolla A -- Nutrients
Panax ginseng and aging related disorders: A systematic reviewEmergingSystematic review2022
PRECLINICAL/REVIEW: A systematic review summarizes evidence that Panax ginseng supports mitochondrial and antioxidant function in aging-related models, an area still lacking direct human bioenergetic trials.
de Oliveira Zanuso B; de Oliveira Dos Santos AR; Miola VFB; Guissoni Campos LM; Spilla CSG; Barbalho SM -- Experimental gerontology
Exploratory Systematic Review and Meta-Analysis of Panax Genus Plant Ingestion Evaluation in Exercise EnduranceEmergingMeta-analysis2022
A systematic review and meta-analysis found Panax-genus plants and ginsenosides tended to extend time-to-exhaustion in endurance tests, but heterogeneity and unreported ginsenoside content weaken the conclusion.
Ikeuchi S; Minamida M; Nakamura T; Konishi M; Kamioka H -- Nutrients
The effect of ginseng extract on fatigue in cancer survivors: a randomized double-blind clinical trialEmergingRandomized controlled trial2026
In a double-blind randomized trial in cancer survivors, standardized Panax ginseng extract was associated with lower self-reported fatigue versus placebo, supporting ginseng's traditional role in resisting fatigue.
Rahmani A; Sanaat Z; H HN; Shamsi A; Ghaderi M -- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled StudyEmergingRandomized controlled trial2025
A randomized placebo-controlled trial in moderately stressed adults found a high-rare-ginsenoside red Panax ginseng lowered perceived stress and improved some emotional-processing and cognitive measures.
Dormal V; Jonniaux L; Buchet M; Simar L; Copine S; Deldicque L -- Nutrients
Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialEmergingRandomized controlled trial2024
A 12-week randomized placebo-controlled trial reported a standardized Panax ginseng sprout extract improved memory test scores in older adults with subjective memory complaints.
Baek HI; Ha KC; Park YK; Kim TY; Park SJ -- Nutrients
Short-Term Panax Ginseng Extract Supplementation Reduces Fasting Blood Triacylglycerides and Oxygen Consumption during Sub-Maximal Aerobic Exercise in Male Recreational AthletesEmergingRandomized controlled trial2024
A 14-day randomized double-blind trial in male recreational runners found Panax ginseng extract lowered oxygen consumption during sub-maximal exercise, but reported triglyceride reductions were not statistically significant, with confidence intervals crossing zero.
Hernández-García D; Granado-Serrano AB; Martín-Gari M; Ensenyat A; Naudí A; Serrano JCE -- Biomolecules
Pharmacological mechanisms and drug delivery systems of ginsenoside Rg3: A comprehensive reviewEmergingExpert review2025
A comprehensive review characterizes the rare ginsenoside Rg3 as a high-potency minor ginsenoside with broad antioxidant and anti-inflammatory activity but poor solubility, motivating enhanced-delivery formulations.
Yao ZW; Zhu H -- Pharmacological research
Recent trends in ginseng researchEmergingExpert review2024
A review of recent ginseng research maps active ginsenosides to molecular targets and gene-expression pathways, while human nutrigenomic (transcriptome) trials of ginseng remain sparse.
Ito H; Ito M -- Journal of natural medicines
Rare ginsenosides: A unique perspective of ginseng researchEmergingExpert review2024
A review defines rare ginsenosides (Rg3, Rh2, compound K) as deglycosylated products of processing or gut metabolism that are low in abundance yet substantially more potent than the primary ginsenosides they come from.
Fan W; Fan L; Wang Z; Mei Y; Liu L; Li L; Yang L; Wang Z -- Journal of advanced research
Ginsenoside Rg1 in neurological diseases: From bench to bedsideEmergingExpert review2023
PRECLINICAL/REVIEW: A bench-to-bedside review details ginsenoside Rg1's anti-inflammatory, antioxidant, and neuroprotective actions relevant to mental resilience, with human data still emerging.
Yang SJ; Wang JJ; Cheng P; Chen LX; Hu JM; Zhu GQ -- Acta pharmacologica Sinica
Ginsenoside Rd alleviates LPS-induced neuroinflammation and depressive-like behaviors via regulating TLR4-PI3K-NF-κB-JMJD3 signalingEmergingAnimal study2025
PRECLINICAL: Ginsenoside Rd modulated TLR4-PI3K-NF-kB signaling and the epigenetic demethylase JMJD3 to lower neuroinflammation in mice, illustrating ginsenoside effects on host gene-regulatory pathways.
Chen H; Piao J; Geng Z; Han X; Li R; Cui R; Li B -- International immunopharmacology
Ginsenoside Rg3 Restores Mitochondrial Cardiolipin Homeostasis via GRB2 to Prevent Parkinson's DiseaseEmergingPreclinical study2024
PRECLINICAL: In cell and animal models, ginsenoside Rg3 restored mitochondrial cardiolipin balance via GRB2, improving mitochondrial homeostasis; not yet tested in humans.
Qi LF; Liu S; Fang Q; Qian C; Peng C; Liu Y; Yang P; Wu P; Shan L; Cui Q; Hua Q; Yang S; Ye C; Yang W; Li P; Xu X -- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Synergistic Actions of Natural Compounds for Enhancing Cognitive and Physical Performance: A Narrative ReviewEmerging2026
A narrative review argues energy drinks rely narrowly on caffeine, and reviews guayusa, Alpinia galanga, L-citrulline, beetroot and cordyceps as agents that may enhance vascular and mitochondrial energy pathways, though standardisation and dosing vary widely.
Raghav Panda; Harvey N Mayrovitz
Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin.2026
In diabetic mice and keratinocyte cell models, Cordyceps militaris extract accelerated wound closure and epidermal regeneration by restoring HIF-1alpha and TGF-beta1 expression and modulating SIRT1/Nrf2/HO-1 signaling.
Lin TK; Tsai CL; Tsai BC; Kuo CH; Ho TJ; Hsieh DJ; Kuo WW; Huang CY; Lee PY -- Life (Basel, Switzerland)
Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory FrameworkEmerging2026
Integrating 9 clinical systematic reviews and 37 network pharmacology studies, this review found recurrent PI3K-Akt and AMPK-mTOR hubs and notes oral cordycepin reaches only nanomolar systemic concentrations.
Alexander Panossian
Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.2026
Cordyceps militaris strain KTDT8 produced the highest cordycepin, adenosine, and polysaccharide levels along with the strongest antioxidant activity, remaining genetically stable across four generations of cultivation.
Thi Gam D; Ngoc Minh T; Khac Hung N; Thuy Diep N; Thi Thuy T; Thi Dung K; Thi Thanh Ha D; Thi Phuong Doai N; Tien Phat D; Thi Huyen T; Huu Trung K -- Current drug metabolism
Extracts from Cordyceps cicadae and Hericium erinaceus promote the neurite outgrowth of retinal ganglion cellsEmerging2026
Aqueous Cordyceps cicadae extract, ethanolic Hericium erinaceus extract and purified erinacine S promoted neurite outgrowth in mouse retinal explants and isolated ganglion cells, though excessive concentrations inhibited growth.
Fang-Yi Chen; Chin-Chu Chen; Chuan-Chin Chiao
Comparative bioaccumulation and biotransformation of selenate, selenite, and selenomethionine in Cordyceps militaris.2026
Selenomethionine showed faster absorption than selenite or selenate in Cordyceps militaris mycelium, with sulfur, phosphorus, and methionine competitively reducing selenium uptake, identifying selenite as the optimal biofortification form.
Zhang Y; Hu T; Zhao B; Guo Y -- Biochemistry and biophysics reports
Maintaining the Quality and Nutritional Integrity of Chilled <i>Cordyceps sinensis</i>: Comparative Effects and Mechanisms of Modified Atmosphere Packaging and UV-Based InterventionsEmerging2025
During 12-day chilled storage of Cordyceps sinensis at 4 degrees C, vacuum packing cut weight loss to 3.49% versus 10.77% in controls, and UV lowered polyphenol oxidase activity 36.4%.
Tianzhuo Huang; Huanzhi Lv; Yubo Lin; Xin Xiong; Yuqing Tan; Hui Hong; Yongkang Luo
Nature's marvel: unravelling the multiphase composition of Cordyceps militaris mushroom and its implications as a dietary supplement.2026
A review characterizes the multiphase chemical composition of Cordyceps militaris mushroom, examining its profile as a dietary supplement ingredient.
Parthasarathy S; Tharumasivam SV; Aly SH; Giridharan B; Durairaj S; Elbadry AMM; El-Shazly M -- Journal of food science and technology
The Genus <i>Cordyceps</i> Sensu Lato: Their Chemical Constituents, Biological Activities, and Therapeutic Effects on Air Pollutants Related to Lung and Vascular DiseasesEmerging2025
This review of Cordyceps species reports a randomised trial in 20 healthy adults where 2.85 mg cordycepin daily for 60 days raised NK cell activity, and another in 100 adults raising NK cytotoxicity and serum IgA.
Hye-Jin Park
Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action.2026
A review found that Cordyceps species and their bioactive components, including cordycepin, showed anti-cancer activity in preclinical studies through apoptosis induction, cell-cycle arrest, and signaling pathway modulation.
Gunter NV; Ong YS; Lai ZW; Morita H; Chamyuang S; Owatworakit A; Mah SH -- Journal of Asian natural products research
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC R2 Day is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC R2 Day pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Energy & Mitochondria
For Mood & Hormones
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take six capsules in the morning, with or without food, and pair with R2 Night in the evening -- the two halves are designed to be used together. Follow the current label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC R2 DayThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC R2 is a two-part daily system built to support the cell's own renewal and energy pathways as we age. One part leans toward daytime purification support, the other toward overnight energy and renewal support. It fits people who want a thoughtfully timed longevity routine rather than one generic pill.
FAQ
What does ageLOC R2 support?
It supports the cell's natural renewal processes, the body's normal antioxidant defenses, healthy cellular energy production, and healthy cellular aging over time. It supports the body's own renewal; it does not reverse aging or reset genes.
How do I take it?
Take the daytime portion in the morning and the evening portion at night, each with water, following the pack layout. The morning-and-night rhythm is the whole point, so keep both consistent.
What makes it different?
It is two formulas timed to the body's day-and-night rhythm, aimed at supporting the cell's own maintenance machinery rather than a single all-day dose.