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What it is
This is the daytime engine of ageLOC R2 -- six morning capsules of cordyceps Cs-4, Panax ginseng, and pomegranate that work the epigenetics of energy. R2 is a two-part system: R2 Night runs the overnight genetic detox, and R2 Day targets the other side -- the gene-expression patterns behind cellular ENERGY production, right where the mitochondria turn food into usable fuel. The daytime vitality that rides on that engine is the point: physical vigor, mental acuity, and sexual health.
Why the evidence supports it
The honest frame, straight from the product's own science, is energy -- not detox (that is R2 Night's job). The ageLOC method behind R2 compared age-related gene-expression patterns and screened natural compounds for the ones that shifted the cellular-energy pattern toward a more youthful state, selecting cordyceps, ginseng, and pomegranate on that basis -- and the ageLOC Vitality research it grew from mapped that gene modulation across three tissues at once: brain, heart, and skeletal muscle (the specific gene count is Nu Skin's own figure). Each ingredient carries its own human evidence for that daytime story: cordyceps Cs-4 for exercise capacity and oxygen use (VO2max), Panax ginseng for energy and fatigue, mental acuity, and sexual vitality in both men and women, and pomegranate for mitochondrial support. Graded honestly, most of that ingredient evidence is emerging rather than settled, and the finished-formula gene-expression claim is emerging -- so this supports the cell's Transform function and daytime vitality, it does not treat fatigue or any condition.
What it supports
- Supports cellular energy production and mitochondrial function
- Supports daytime physical vigor and stamina
- Supports mental acuity and everyday cognition
- Supports healthy libido and sexual vitality in men and women
Which function it supports
Ties to the cell's Transform function -- supporting youthful gene expression for cellular energy production (the mitochondria) across brain, heart, and skeletal muscle, and the daytime vitality that depends on it. NRF2/purification is R2 Night's role, not this one.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision US Supplement Facts image from the US product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed.
| Amount per 6 capsules | Amount | % DV |
|---|---|---|
| Calories | 10 | |
| Total Carbohydrates | 2 g | 1%** |
| Dietary Fiber | <1 g | 2%** |
| Protein | 1 g | |
| ageLOC Recharge BlendCordyceps Cs-4 mushroom mycelia (Paecilomyces hepiali), pomegranate (Punica granatum) fruit extract, Pharmanex Asian ginseng Rb1 (Panax ginseng) root extract | 2270 mg | * |
- Servings per container:
- 30
US panel. The only PIP linked from this product's page is the SINGAPORE edition (ageLOC-R2-PIP-SG.pdf, nuskin.com.sg in the footer), so the US Supplement Facts image is the source here. If a US PIP appears, re-verify against it.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performancePubMed
International Journal of Sport Nutrition and Exercise Metabolism · 2004
A randomized, placebo-controlled trial in trained cyclists found that five weeks of Cordyceps sinensis supplementation did not significantly improve aerobic capacity or endurance performance, an honest null finding in already well-trained athletes.
- Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation.PMC
3 weeks of mushroom blend (4g/day) improved VO2max (~10.9%) and time-to-exhaustion vs
In 28 young adults, a randomized placebo-controlled trial of a Cordyceps militaris mushroom blend showed no significant change after one week, and in the 10 continuing three weeks, maximal oxygen uptake improved.
- Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trialPubMed
Journal of Alternative and Complementary Medicine · 2010
Twelve weeks of Cs-4 Cordyceps sinensis raised the metabolic (ventilatory) threshold by about 10 percent in healthy older adults during exercise testing.
- Astragalus and Cordyceps Derivatives in the Treatment of Aging-Related Chronic Diseases and Neurodegenerative DisordersSource
2026
Astragalus and Cordyceps contain multiple bioactive constituents associated with antioxidant, anti-inflammatory, immunomodulatory, and organ-protective effects in experimental models.
- Cordyceps sinensis and Sonodynamic Therapy in Non-Small Cell Lung Cancer: Pharmacological Basis, Therapeutic Potential, and Future DirectionsPubMed
2026
A narrative review argued that water-based decoctions of a medicinal fungus carry inorganic arsenic at roughly four times the Chinese Pharmacopoeia limit, and proposed magnetic nanoparticles with focused ultrasound as a workaround.
- Pharmacological and economical aspects of important species of Cordyceps sensu lato: A reviewPubMed
Cellular and molecular biology (Noisy-le-Grand, France) · 2024
A comprehensive review examines the pharmacological properties, nutritional value, and economic importance of four Cordyceps species commonly used in traditional medicine and supplements.
The effect of ginseng extract on fatigue in cancer survivors: a randomized double-blind clinical trialEmergingRandomized controlled trial2026
In a double-blind randomized trial in cancer survivors, standardized Panax ginseng extract was associated with lower self-reported fatigue versus placebo, supporting ginseng's traditional role in resisting fatigue.
Rahmani A; Sanaat Z; H HN; Shamsi A; Ghaderi M -- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Skeletal muscle mitochondrial-methylation-neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populationsEmergingExpert review2026
This review proposes an untested theoretical model integrating Cordyceps, betaine, and tyrosine for exercise performance; mechanistic and clinical evidence is needed to evaluate efficacy.
Chunhong Xu; Weilu Cai; Jing Li; Ying Ma
Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans-A Narrative ReviewEmergingExpert review2026
Five small studies examining Cordyceps militaris supplementation in athletes reported inconsistent effects on performance and recovery, with quality limited by heterogeneous protocols.
Maciej Jędrejko; Karol Jędrejko; Dominika Granda; Katarzyna Kała; Andrzej Pokrywka; Bożena Muszyńska
Astragalus and Cordyceps Derivatives in the Treatment of Aging-Related Chronic Diseases and Neurodegenerative DisordersEmergingExpert review2026
Astragalus and Cordyceps contain multiple bioactive constituents associated with antioxidant, anti-inflammatory, immunomodulatory, and organ-protective effects in experimental models.
Kiran Reddy Kanubaddi; Chih-Liang Yaung; Horng-Jyh Harn; Tzyy-Wen Chiou; Shao-Xi Hsu; Ivan Wijaya; Shinn-Zong Lin; Wei Wuli
Extracts from Cordyceps cicadae and Hericium erinaceus promote the neurite outgrowth of retinal ganglion cellsEmerging2026
Aqueous Cordyceps cicadae extract, ethanolic Hericium erinaceus extract and purified erinacine S promoted neurite outgrowth in mouse retinal explants and isolated ganglion cells, though excessive concentrations inhibited growth.
Fang-Yi Chen; Chin-Chu Chen; Chuan-Chin Chiao
Nature's marvel: unravelling the multiphase composition of Cordyceps militaris mushroom and its implications as a dietary supplement.2026
A review characterizes the multiphase chemical composition of Cordyceps militaris mushroom, examining its profile as a dietary supplement ingredient.
Parthasarathy S; Tharumasivam SV; Aly SH; Giridharan B; Durairaj S; Elbadry AMM; El-Shazly M -- Journal of food science and technology
New Pyridinone Alkaloid and Polyketide from the Cordyceps-Colonizing Fungus Pseudogymnoascus roseusEmergingPrimary research (design unspecified)2026
Harzianic acid isolated from Pseudogymnoascus roseus showed cytotoxicity to lung and gastric cancer cell lines in vitro.
Jie Lin; Yutong Guo; Jing Wang; Fang Wang; Ling Liu
Comparative bioaccumulation and biotransformation of selenate, selenite, and selenomethionine in Cordyceps militaris.2026
Selenomethionine showed faster absorption than selenite or selenate in Cordyceps militaris mycelium, with sulfur, phosphorus, and methionine competitively reducing selenium uptake, identifying selenite as the optimal biofortification form.
Zhang Y; Hu T; Zhao B; Guo Y -- Biochemistry and biophysics reports
Drying-Induced Changes in Metabolite Profiles and Antioxidant Activity of Cordyceps militaris: Insights from Integrated Metabolomics and Network PharmacologyEmergingPrimary research (design unspecified)2026
Vacuum freeze drying and vacuum drying of Cordyceps militaris better preserved bioactive compounds and antioxidant activity than oven or sun drying.
Xiaodan Wu; Weidi Fu; Wen Zhang; Hao Yu; Jian-Shuang Zhang -- Foods
Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.2026
Cordyceps militaris strain KTDT8 produced the highest cordycepin, adenosine, and polysaccharide levels along with the strongest antioxidant activity, remaining genetically stable across four generations of cultivation.
Thi Gam D; Ngoc Minh T; Khac Hung N; Thuy Diep N; Thi Thuy T; Thi Dung K; Thi Thanh Ha D; Thi Phuong Doai N; Tien Phat D; Thi Huyen T; Huu Trung K -- Current drug metabolism
A Review on Adaptogenic Mushrooms: Bioactive Compounds and Pharmacological InsightsEmergingPrimary research (design unspecified)2026
Adaptogenic mushrooms including Ganoderma lucidum and Cordyceps exhibited anti-inflammatory, neuroprotective, and metabolic effects through HPA axis and NRF2 pathway activation.
Adhikari, Pragati; Raj, Rishu; Fayaz, Asma; Kundal, Munish -- Journal of Advances in Biology & Biotechnology
Medicinal Mushrooms and Their Bioactive Compounds: From Traditional Use to Therapeutic Potential.2026
Medicinal mushrooms including Cordyceps militaris, Ganoderma lucidum, and Grifola frondosa contain polysaccharides and triterpenoids studied for immune support, anti-inflammatory, antioxidant, antimicrobial, and anticancer bioactivity across preclinical and clinical research.
Sadowska A; Włosek-Pawełas D; Car H -- Molecules (Basel, Switzerland)
Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory FrameworkEmerging2026
Integrating 9 clinical systematic reviews and 37 network pharmacology studies, this review found recurrent PI3K-Akt and AMPK-mTOR hubs and notes oral cordycepin reaches only nanomolar systemic concentrations.
Alexander Panossian
Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin.2026
In diabetic mice and keratinocyte cell models, Cordyceps militaris extract accelerated wound closure and epidermal regeneration by restoring HIF-1alpha and TGF-beta1 expression and modulating SIRT1/Nrf2/HO-1 signaling.
Lin TK; Tsai CL; Tsai BC; Kuo CH; Ho TJ; Hsieh DJ; Kuo WW; Huang CY; Lee PY -- Life (Basel, Switzerland)
Effects of Protease-Hydrolyzed and Cordyceps militaris-Fermented Sea Cucumber Viscera Hydrolysates on Cellular Function and Energy Metabolism in HCT116 CellsEmergingPrimary research (design unspecified)2026
Sea cucumber viscera hydrolysates induced colorectal cancer cell apoptosis and suppressed migration/invasion, with fermentation distinctly modifying glycolytic versus mitochondrial energy metabolism effects.
Biyi Chen; Yuyang Li; Xinghe Chen; Xinyue Jia; Ying Li; Rui Mi; Zunchun Zhou
Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action.2026
A review found that Cordyceps species and their bioactive components, including cordycepin, showed anti-cancer activity in preclinical studies through apoptosis induction, cell-cycle arrest, and signaling pathway modulation.
Gunter NV; Ong YS; Lai ZW; Morita H; Chamyuang S; Owatworakit A; Mah SH -- Journal of Asian natural products research
Anti-Inflammatory Mechanisms and Translational Relevance of Cordyceps sinensis and Its Bioactive ConstituentsEmergingPrimary research (design unspecified)2026
Cordyceps sinensis cordycepin, cordycepic acid, polysaccharides and sterols exerted anti-inflammatory effects in respiratory, autoimmune, neuroinflammatory, and metabolic diseases.
Jiahao Xie; Jingwen Xu; Qi Fan; Yu-Chan Chen -- Journal of Inflammation Research
Enhanced Antioxidant and Anti-inflammatory Properties of Albino Cordyceps militaris: A Comparative Study With Wild-type Strain.2025
A comparative study found an albino Cordyceps militaris strain had higher cordycepin and pentostatin levels and stronger antioxidant radical-scavenging, copper-chelating, and anti-inflammatory activity than the wild-type strain.
Vu TX; Nguyen MT; Dao AN; Tran TB; Le YTH; Tran VT; Nguyen TH; Nguyen QV -- Chemistry & biodiversity
Synergistic Actions of Natural Compounds for Enhancing Cognitive and Physical Performance: A Narrative ReviewEmerging2026
A narrative review argues energy drinks rely narrowly on caffeine, and reviews guayusa, Alpinia galanga, L-citrulline, beetroot and cordyceps as agents that may enhance vascular and mitochondrial energy pathways, though standardisation and dosing vary widely.
Raghav Panda; Harvey N Mayrovitz
Fungal Polysaccharides as Modulators of Molecular Pathways in Liver Health.2025
This review synthesizes evidence that fungal polysaccharides from species including Cordyceps militaris, shiitake, and reishi reduce oxidative stress and inflammation and improve metabolic homeostasis relevant to alcohol-related and fatty liver disease.
Szelenberger R; Więckowska M -- Molecules (Basel, Switzerland)
Morpho-Genetic Characterization and Bioactivity Evaluation of Cordyceps militaris cultivated on Various SubstratesEmergingPrimary research (design unspecified)2025
Ethanolic extracts from Cordyceps militaris cultivated on foxtail millet and brown rice substrates showed strong antimicrobial and antioxidant activities, with substrate composition significantly influencing bioactive compound production.
Akhil Sharma; Vikas Sharma; Shivika Sharma; Amit Kumar -- Research Journal of Biotechnology
Light-responsive transcription factor CmOzf integrates conidiation, fruiting body development, and secondary metabolism in Cordyceps militaris.2025
In Cordyceps militaris, disruption of the CmOzf gene impaired conidial development and altered polysaccharide and carotenoid accumulation, revealing a light-responsive regulatory circuit involving the photoreceptor gene Cmwc-1.
Chen J-f; Cheng F-l; Chen T-y; Xu Y-l; Song J-m; Wang H-m; Zhang Y; Guo X-c; Luo J -- Microbiology spectrum
Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes.2025
In 3T3-L1 adipocytes and a diabetic obese mouse model, Cordyceps militaris extract and its compound cordycepin reduced lipid droplet formation, increased hormone-sensitive lipase activation, lowered LDL/VLDL cholesterol, and reduced oxidative stress and cell senescence markers.
Kusama K; Oka K; Yashiro Y; Yoshida K; Miyaoka H; Tamura K -- FEBS open bio
Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris.2025
Researchers identified and functionally analyzed the SET domain-containing gene family in Cordyceps militaris, finding these genes regulate secondary metabolite biosynthesis through histone lysine methylation modifications.
Lu Y; Zhang Y; Yao L; Yuan D; Yao B; Zhou B; He B -- Scientific reports
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Fecal Calprotectinemerging evidence
via Pomegranate extract · 1 studies, 1 in people
A 12-week juice intervention with a modulatory effect on the relevant transcriptional profile.
What people often notice when this marker sits outside the usual range
Higher: Diarrhoea, often with urgency; blood or mucus in stool.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. ageLOC R2 Day is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what ageLOC R2 Day pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Energy & Mitochondria
For Mood & Hormones
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take six capsules in the morning, with or without food, and pair with R2 Night in the evening -- the two halves are designed to be used together. Follow the current label.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get ageLOC R2 DayThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
ageLOC R2 is a two-part daily system built to support the cell's own renewal and energy pathways as we age. One part leans toward daytime purification support, the other toward overnight energy and renewal support. It fits people who want a thoughtfully timed longevity routine rather than one generic pill.
FAQ
What does ageLOC R2 support?
It supports the cell's natural renewal processes, the body's normal antioxidant defenses, healthy cellular energy production, and healthy cellular aging over time. It supports the body's own renewal; it does not reverse aging or reset genes.
How do I take it?
Take the daytime portion in the morning and the evening portion at night, each with water, following the pack layout. The morning-and-night rhythm is the whole point, so keep both consistent.
What makes it different?
It is two formulas timed to the body's day-and-night rhythm, aimed at supporting the cell's own maintenance machinery rather than a single all-day dose.