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When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
A juice blend built around four deeply pigmented, carotenoid- and polyphenol-rich fruits -- gac, cili (Rosa roxburghii), sea buckthorn, and Chinese lycium (wolfberry) -- rounded out with pear, grape, and apple. Taken as about 60 mL daily, it draws on Pharmanex's plant-medicine heritage as a whole-fruit way to take in dietary antioxidants.
Why the evidence supports it
The four signature fruits are genuinely among the more carotenoid- and polyphenol-dense foods studied, and the broader research on dietary carotenoids consistently ties them to the body's antioxidant defenses and healthy cellular aging -- and, more specifically, to skin that handles light better from the inside, since carotenoids concentrate in the skin, and, more modestly, to normal immune function, where they also collect. Because carotenoids are fat-soluble, taking it with a little dietary fat is what actually gets them absorbed. The honest limits: it is made from fruit concentrates, so it is not a stand-in for whole fruit and fiber, and the exact carotenoid content per serving is not fully disclosed. Framed that way, it is a pleasant, evidence-based way to feed the cell's Maintain function -- dietary antioxidants that help cells buffer oxidative stress and hold their healthy baseline, with skin and immune tissue among the first to draw on them.
What it supports
- Supports the body's normal antioxidant defenses
- Provides carotenoids and polyphenols from deeply pigmented fruits
- Supports healthy cellular aging as part of a balanced diet
- Complements a diet rich in whole fruits and vegetables
Which function it supports
Ties to the cell's Maintain function -- dietary carotenoids and polyphenols help buffer oxidative stress so cells can hold their healthy baseline.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Radioprotective effect and antioxidant activities of Thai Gac fruit (Momordica cochinchinensis Spreng)DOI
Journal of Associated Medical Sciences · 2026
Ethanolic peel extract of Thai Gac fruit showed a dose-dependent radioprotective effect in TK6 lymphoblast cells after gamma irradiation, with the highest antioxidant activity among extracts tested.
- Modulation of the gut microbiota and short-chain fatty acid production by gac fruit juice and its fermentation in in vitro colonic fermentation.DOI
Food & Function · 2024
In vitro colonic fermentation of gac fruit juice, with or without Lactobacillus paracasei fermentation, increased short-chain fatty acid levels and promoted beneficial gut bacteria in human fecal samples.
- Development of probiotic fermented beverage from gac fruit (Momordica cochinchinensis) and its functional properties on gut healthDOI
2026
Fermenting gac juice with Lactobacillus paracasei raised probiotic viability to 10 to the 8 CFU per millilitre and beta-carotene, and in colonic fermentation increased short-chain fatty acids and Akkermansia while inhibiting Escherichia coli.
- Assessment of engineering and physicochemical properties of Gac fruit and predictive mass modeling for physical attributesSource
2025
Characterising Gac fruit, a power model best predicted mass from geometric dimensions (R2 0.976), and the aril contained 3.56 mg/g beta-carotene and 2.98 mg/g lycopene.
- Neuroprotective Effect of Fresh Gac Fruit Parts Against β-Amyloid-Induced Toxicity and Its Influence on Synaptic Gene Expression in HT-22 Cell Model.PubMed
Molecules (Basel, Switzerland) · 2025
In neuronal HT-22 cells, ethanol and ethyl acetate extracts from gac fruit peel and seed protected against amyloid-beta-induced cell death, reduced ROS and mitochondrial dysfunction, and preserved synaptic proteins like PSD-95.
- Brain acetylcholinesterase activity and the protective effect of Gac fruit on scopolamine-induced memory impairment in adult zebrafish.PubMed
IBRO neuroscience reports · 2024
In zebrafish with scopolamine-induced memory impairment, Gac fruit extract showed anti-memory-impairment activity on maze-based behavioral tests, suggesting potential relevance to future Alzheimer's-related health product development.
Dietary supplementation with gac (Momordica cochinchinensis) aril powder and oil enhances coloration, hemato-biochemical parameters, and immunity-related gene expression in ornamental goldfishEmergingPrimary research (design unspecified)2026
Gac aril oil (10 g/kg) enhanced carotenoid deposition and stimulated immune-related gene expression in ornamental goldfish.
Anurak Khieokhajonkhet; Wirasinee Noitang; Niran Aeksiri; Narongrit Muangmai; Kumrop Ratanasut; Wilasinee Inyawilert; Kunlayaphat Wuthijaree; Pattaraporn Tatsapong
Production, characterization, and functional properties of protein concentrate from Momordica cochinchinensis seeds.2026
Researchers developed an ultrasound-assisted extraction process to produce a high-purity protein concentrate from Gac seeds, an underutilized agricultural byproduct, achieving over 81% protein purity.
Nguyen AV; Nguyen KK; Le UNT; Tran AM; Nguyen BC; Nguyen HTN; Tran TL; Huynh AP; Vu ATN -- Scientific reports
Bioactive Components and Functional Applications of Sea Buckthorn: A ReviewEmergingExpert review2026
Sea buckthorn's polyphenols, vitamins, and polysaccharides exhibited antioxidant, anti-inflammatory, and hepatoprotective properties with gut microbiota-modulating effects, though clinical validation remains needed.
Xiaogang Guo; Laifeng Zhuo; Yanru Feng; Menghui Lin; Thanh Ninh Le; Minjie Zhao; Haiying Cai
Sea buckthorn for future foods: bioactive mechanisms, synthetic biology, and precision delivery systemsEmergingExpert review2026
Sea buckthorn flavonoids and carotenoids demonstrated antioxidant, anti-inflammatory, and cardioprotective properties; synthetic biology and delivery systems enhanced bioavailability.
Li N; Fan P; Wang L; Feng L; Long H; Yang W; Wang J; Zhao Y; Liu H; Guo Y; Gong P -- Food research international (Ottawa, Ont.)
Sea Buckthorn in Cardiovascular and Metabolic Health: Evidence for the Role of the LeavesEmergingExpert review2026
Sea buckthorn leaf preparations lack sufficient controlled human evidence to support therapeutic claims; only animal and ex vivo data exist.
Aleksandra Kordas; Michał S Majewski
Nutrient assessment of sea buckthorn residues as potential feed ingredientsEmergingPrimary research (design unspecified)2026
An analysis of sea buckthorn processing residues found the seedless pomace was especially rich in vitamin E (720 mg/kg dry matter), highlighting it as a potential antioxidant-rich livestock feed ingredient, not a tested health outcome.
Dunja Malenica; Rajeev Bhat; Marko Kass; Ragnar Leming; Larissa Silva Maciel; Koit Herodes; Meelis Ots
Sea buckthorn flavonoids protect RPE cells from UVB-induced oxidative damage.2026
In a cell model, sea buckthorn flavonoids, including rutin and isorhamnetin glucosides, increased retinal pigment epithelial cell viability and antioxidant enzyme activity while reducing UVB-induced oxidative damage.
Yang S; Zhang Z; Zhang Y; Huang Y; Chen X -- Natural product research
Sea buckthorn polyphenols improve lipid metabolism via gut-liver axis modulation in db/db miceEmergingPrimary research (design unspecified)2026
Sea buckthorn polyphenols reduced hepatic steatosis and restored HDL by modulating beneficial gut microbiota and hepatic lipid metabolism pathways.
Zongzhen Guo; Ziyi Yuan; Tiangang Xu; Yian Yao; Yiyun Zhang; Zongxin Shao; Qun Shen; Yong Xue
Chemical Profiling and In Vivo Evaluation of Sea Buckthorn-Derived Matrices in Drosophila melanogaster Under Varied Dietary Regimes.2026
In Drosophila melanogaster raised on nutrient-poor and high-sugar diets, sea buckthorn fruit pomace powder, rich in protein and polyphenols, best supported larval and adult viability and normal development compared with seed oil or pulp.
Héjja M; Nagy R; Tankó G; Lóga FÁ; Pecsenye B; Bancea G; Mposula Z; Cziáky Z; Pacza T; Máthé E -- Nutrients
Selenium-enriched strawberry-sea buckthorn-yam juice fermented by Weissella cibaria and Pediococcus acidilactici: antioxidant, flavor, and immunomodulatory effectsEmergingPrimary research (design unspecified)2026
Selenium-enriched fermented fruit juice enhanced antioxidant defense, immune function, and intestinal health while alleviating dysbiosis in immunocompromised mice.
He Xu; Chunlin Ban; Dezhen Wang; Qingdong Wang; Zhenlong Wang
A comparative dataset on LC-MS analysis of sea buckthorn berries pulped extract juice phytocompounds and metabolomics on probiotic fermentation.2026
Metabolomic analysis found that fermenting sea buckthorn berry pulp and juice with Lactobacillus plantarum altered the phytocompound profile compared to unfermented juice and standard growth medium.
Chandel V; Mathur A -- Data in brief
Study on the Effects and Mechanisms of Sea Buckthorn Fruit Pulp in Improving Polycystic Ovary SyndromeEmergingPrimary research (design unspecified)2026
In letrozole-induced PCOS mice, sea buckthorn fruit pulp lowered testosterone and LH, partially restored estradiol, and improved glucose tolerance and ovarian morphology, likely via the PI3K/AKT/mTOR pathway.
Han Xiaoya; Yang Yuanyuan; Peng Qingjie; Chen Xiaojiang; Ma Cunling; Li Na; Tian Xiaofan; Wu Xin; Liu Hetao; He Rui
Biodegradable coating based on chitosan and sea buckthorn for fish fillet preservation.2026
A chitosan coating with sea buckthorn oil reduced microbial growth in refrigerated fish fillets and extended shelf life by about three days compared to plain chitosan coating, over 12 days of storage.
Kara A; Alak G -- Scientific reports
Network pharmacology and experimental evidence implicate ERα-associated β-catenin regulation in the osteoprotective effects of sea buckthorn fruit extractEmergingPreprint2026
Sea buckthorn fruit extract improved bone microarchitecture and remodeling balance in postmenopausal mouse model through estrogen receptor alpha-associated signaling.
Liangliang Wei; Yong Wang; Zhihao Xia; Lei An; Kai Zhou; Shaobo Wu; Jiajia Ji; Yuxing Ye; Leyi Zhao; Junming Liang; Dageng Huang
Preparative Separation of Antioxidants from Sea Buckthorn and Its Antioxidant Activity In Vitro via Endothelial Function Regulation.2026
Two sea buckthorn compounds showed antioxidant activity in lab assays; their binding to redox proteins SOD, Nrf2, and eNOS was predicted by computer docking, not confirmed by direct binding experiments.
Cheng Y; Kang W; Hu J; Fan X; Nan X; Zhang Z; Yang F -- International journal of molecular sciences
A sea buckthorn seed oil nano-emulsion in the management of digital screen-induced ocular conditions.EmergingPrimary research (design unspecified)2026
Sea buckthorn seed oil nano-emulsion delayed myopia progression in rabbits with efficacy comparable to atropine but without inducing dry eye side effects.
M. Cheng; Xiao-Shuang Bi; Shan Zhao; Ruolan Xiang; Shunqiao Cai; Meiting Zhao; Tao Wu; Yu‐tong Su; M. Ji; Jian Zhao; Tian Yin; Yu Zhang -- European journal of pharmaceutics and biopharmaceutics
Enzymatic Deastringent Fruit Powder of Sea Buckthorn (Hippophae rhamnoides L.): Preparation, Antioxidant Activity Investigation and Metabolomics Analysis.2026
Combined pectinase-tannase enzymatic treatment reduced sourness and astringency in sea buckthorn berries while preserving antioxidant activity, altering 36 metabolites linked to sensory attributes.
Xie J; Lin L; Yang H; Wu D; Zhang Z; Lin S; Kang F; Zhang L; Li J -- Foods (Basel, Switzerland)
FLAXSEED, SEA BUCKTHORN AND CORNELIAN CHERRY IN TYPE 2 DIABETES: GUT MICROBIOTA AND METABOLIC BENEFITS -- A NARRATIVE REVIEWEmergingPrimary research (design unspecified)2026
This narrative review concludes that flaxseed, sea buckthorn and Cornelian cherry compounds may support gut barrier integrity, reduce endotoxemia and inflammation, and improve glucose and lipid handling relevant to type 2 diabetes.
Alžbeta Piovarčiová; Marcela Capcarová; Jiřina Zemanová; L. Hleba; N. Žáčik; A. Greń; R. Muchacka; E. R. Schneir; P. Massányi -- Journal of Microbiology, Biotechnology and Food Sciences
Different drying methods drive divergent quality profiles in sea buckthorn protein hydrolysates: antioxidant preservation versus aroma complexityEmergingPrimary research (design unspecified)2026
Vacuum freeze-drying of sea buckthorn peptides preserved superior antioxidant capacity compared to spray-drying or microwave vacuum drying.
Chen Chen; Pan Zhang; Yuqian Wei; Xiaoyue Liang; Le Wang; Xi-Zhe Fu; Jian Zhang; Yue Zhao -- Food Chemistry: X
Hippophae rhamnoides: Way to Ameliorate Depressive Augury by CyanocobalaminEmergingNarrative review2026
This review describes preclinical and clinical evidence that vitamin B12, including from the plant Hippophae rhamnoides, modulates inflammation and serotonin and dopamine pathways and is associated with reduced depression symptoms alongside antidepressants.
Kalpana Garg; Sakshi Bajaj; Romi Rajput; Riya Singla
Investıgatıon of the In vitro and In vivo effect of a mixture of Ficus carica L. and Hippophae rhamnoides L. on experımentally induced burns in rats.EmergingPreclinical study2026
Preclinical findings indicate that Sea buckthorn supports Build function through tissue repair and structural protein synthesis pathways, providing a mechanistic basis for tissue regeneration.
Bayrakceken HU, Sulumer AN, Avci B, et al -- Burns : journal of the International Society for Burn Injuries
Bioactive spectrum of goji berries (Lycium spp.) and their functional applications in food systems: A comprehensive reviewEmergingExpert review2026
Goji berries contain bioactive compounds including polysaccharides, phenolics, and carotenoids with antioxidant and anti-inflammatory properties.
Muthu Thiruvengadam; Hee-Youn Chi; Ja-Min Lee; Yunwoo Park; Dagyeom Jeon; Seung-Bin Lee; Yong-Ik Jin; Hae Won Jang; Rekha Thiruvengadam; Baskar Venkidasamy; Seung-Hyun Kim
From Whole-Plant Phytochemistry to Precision Oncology: A Paradigm-Shifting Systematic Review of Lycium barbarum L. (Goji Berries)EmergingExpert review2026
Goji berries contain bioactive compounds supporting antioxidant, anti-inflammatory, and immunomodulatory effects, with preclinical evidence for antitumor potential via multiple cell death pathways.
Yuanhong Lan; Lanfei Ma; Yuxin Kong; Dina Mahemuti; Congcong Zhang; Yuxiang Zhang; Wenfang Li; Ayitila Maimaitijiang
Goji Leaves and Buds as Food Resources: Composition, Processing, Safety, and Links to Side-Stream ValorizationEmergingExpert review2026
Goji leaf and bud composition varies substantially with genotype and harvest stage; their effects in food matrices are dose- and formulation-dependent.
Jinhao Zou; Xiaowei Tian; Siyi Wang; Ye Sun
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. g3 Juice is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what g3 Juice pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Eyes
For Gut Health
For Immune
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Drink one serving of about 60 mL daily, on its own or with a meal. Because it contains fruit concentrates, treat it as a supplement to whole fruit, not a replacement.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get g3 JuiceThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
g3 Juice is a juice blend built around four pigment- and polyphenol-rich fruits -- gac, cili, sea buckthorn, and Chinese lycium -- rounded out with pear, grape, and apple. It draws on a plant-medicine heritage as a whole-fruit way to take in antioxidants. It fits people who like their antioxidants the way nature packages them.
FAQ
What does g3 Juice support?
It supports the body's normal antioxidant defenses and healthy cellular aging as part of a balanced diet, provides plant pigments and polyphenols from deeply pigmented fruits, and complements a diet rich in whole fruits and vegetables.
How do I take it?
Drink one small serving daily, on its own or with a meal. Because it contains fruit concentrates, treat it as a supplement to whole fruit, not a replacement.
What makes it different?
These four fruits are genuinely pigment-rich. It contains fruit concentrates rather than whole fruit and fiber, so it is framed as tasty antioxidant support that complements real fruit.