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When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
What it is
A juice blend built around four deeply pigmented, carotenoid- and polyphenol-rich fruits -- gac, cili (Rosa roxburghii), sea buckthorn, and Chinese lycium (wolfberry) -- rounded out with pear, grape, and apple. Taken as about 60 mL daily, it draws on Pharmanex's plant-medicine heritage as a whole-fruit way to take in dietary antioxidants.
Why the evidence supports it
The four signature fruits are genuinely among the more carotenoid- and polyphenol-dense foods studied, and the broader research on dietary carotenoids consistently ties them to the body's antioxidant defenses and healthy cellular aging -- and, more specifically, to skin that handles light better from the inside, since carotenoids concentrate in the skin, and, more modestly, to normal immune function, where they also collect. Because carotenoids are fat-soluble, taking it with a little dietary fat is what actually gets them absorbed. The honest limits: it is made from fruit concentrates, so it is not a stand-in for whole fruit and fiber, and the exact carotenoid content per serving is not fully disclosed. Framed that way, it is a pleasant, evidence-based way to feed the cell's Maintain function -- dietary antioxidants that help cells buffer oxidative stress and hold their healthy baseline, with skin and immune tissue among the first to draw on them.
What it supports
- Supports the body's normal antioxidant defenses
- Provides carotenoids and polyphenols from deeply pigmented fruits
- Supports healthy cellular aging as part of a balanced diet
- Complements a diet rich in whole fruits and vegetables
Which function it supports
Ties to the cell's Maintain function -- dietary carotenoids and polyphenols help buffer oxidative stress so cells can hold their healthy baseline.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Development of probiotic fermented beverage from gac fruit (Momordica cochinchinensis) and its functional properties on gut health
2026
Fermenting gac juice with Lactobacillus paracasei raised probiotic viability to 10 to the 8 CFU per millilitre and beta-carotene, and in colonic fermentation increased short-chain fatty acids and Akkermansia while inhibiting Escherichia coli.
- Assessment of engineering and physicochemical properties of Gac fruit and predictive mass modeling for physical attributes
2025
Characterising Gac fruit, a power model best predicted mass from geometric dimensions (R2 0.976), and the aril contained 3.56 mg/g beta-carotene and 2.98 mg/g lycopene.
- Neuroprotective Effect of Fresh Gac Fruit Parts Against β-Amyloid-Induced Toxicity and Its Influence on Synaptic Gene Expression in HT-22 Cell Model.
Molecules (Basel, Switzerland) · 2025
In neuronal HT-22 cells, ethanol and ethyl acetate extracts from gac fruit peel and seed protected against amyloid-beta-induced cell death, reduced ROS and mitochondrial dysfunction, and preserved synaptic proteins like PSD-95.
- Brain acetylcholinesterase activity and the protective effect of Gac fruit on scopolamine-induced memory impairment in adult zebrafish.
IBRO neuroscience reports · 2024
In zebrafish with scopolamine-induced memory impairment, Gac fruit extract showed anti-memory-impairment activity on maze-based behavioral tests, suggesting potential relevance to future Alzheimer's-related health product development.
- Optimization of Extraction Conditions from Gac Fruit and Utilization of Peel-Derived Biochar for Crystal Violet Dye Removal
2024
Optimized extraction of gac fruit aril yielded oil with strong antioxidant capacity, while biochar made from carbonized gac peel removed up to 91.72% of crystal violet dye from water, best at the highest carbonization temperature.
- Treatment with Gac Fruit Extract and Probiotics Reduces Serum Trimethylamine N-Oxide in Chronic Kidney Disease Rats
2024
In 48 Wistar rats with cisplatin-induced chronic kidney disease, gac fruit extract with probiotics increased Bacteroides, raised ZO-1 expression, reduced faecal TMA lyase and lowered serum trimethylamine N-oxide.
Hydrolysis of zeaxanthin esters by carboxyl ester lipase during digestion facilitates micellarization and uptake of the xanthophyll by Caco-2 human intestinal cells.2006
In lab digestion tests and cultured human intestinal cells, an enzyme in the gut broke down zeaxanthin esters from foods like wolfberry and peppers, and this breakdown increased the cells' uptake of zeaxanthin more than twelvefold.
Chitchumroonchokchai C; Failla ML -- The Journal of nutrition
Inhibition of tumor growth and angiogenesis by water extract of Gac fruit (Momordica cochinchinensis Spreng).2005
In mice implanted with colon cancer cells, a water extract of gac fruit reduced tumor weight by 23.6 percent and blood vessel density around the tumor, and slowed growth of cultured colon and liver cancer cells.
Tien PG; Kayama F; Konishi F; Tamemoto H; Kasono K; Hung NT -- International journal of oncology
Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men.2005
In a study nesting 499 cardiovascular disease cases within the Physicians' Health Study, blood lycopene levels showed no association with cardiovascular disease risk, while higher lutein, zeaxanthin and retinol were linked to a modest, unexplained increase in risk.
Sesso HD; Buring JE; Norkus EP; Gaziano JM -- The American journal of clinical nutrition
DNA damage and aging.2004
A theoretical review proposed that oxidative damage to the DNA of cells, repaired imperfectly by one specific repair pathway, may be a major driver of aging across mammals, based on existing genetic and biochemical research.
Karanjawala ZE; Lieber MR -- Mechanisms of ageing and development
Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum.2004
In rabbits made diabetic or given high-fat diets, wolfberry fruit extracts lowered blood glucose and serum cholesterol and triglycerides while raising HDL cholesterol after ten days, with antioxidant activity also measured in the extracts.
Luo Q; Cai Y; Yan J; Sun M; Corke H -- Life sciences
Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women.2004
In a nested study of nearly 40,000 women followed for almost 5 years, those with higher blood lycopene levels at baseline had a lower risk of later cardiovascular disease, requiring confirmation in further research.
Sesso HD; Buring JE; Norkus EP; Gaziano JM -- The American journal of clinical nutrition
Fatty acid and carotenoid composition of gac (Momordica cochinchinensis Spreng) fruit.2004
Chemical analysis of gac fruit found its oily aril was rich in lycopene and beta-carotene along with oleic, palmitic and linoleic fatty acids, while the seeds were mostly stearic acid, describing composition rather than a health effect.
Ishida BK; Turner C; Chapman MH; McKeon TA -- Journal of agricultural and food chemistry
Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids.2003
In test tube assays, gallic acid and pyrogallol showed the strongest antioxidant and hydrogen peroxide scavenging activity among tested phenolic acids, with potency rising alongside the number of hydroxyl groups on each molecule.
Sroka Z; Cisowski W -- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Evaluation of antioxidant activity of leaf extract of Seabuckthorn (Hippophae rhamnoides L.) on chromium(VI) induced oxidative stress in albino rats.2003
In male rats given a toxic dose of chromium for 30 days, sea buckthorn leaf extract at 100 to 250 mg per kg body weight reduced the chromium-induced drop in glutathione and rise in oxidative stress markers.
Geetha S; Sai Ram M; Mongia SS; Singh V; Ilavazhagan G; Sawhney RC -- Journal of ethnopharmacology
Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects.2003
In 12 young and 17 older healthy adults given 9 mg lutein daily for 5 weeks, blood and cheek-cell lutein rose in both groups, but eye macular pigment density and fat-tissue lutein did not change.
Cardinault N; Gorrand JM; Tyssandier V; Grolier P; Rock E; Borel P -- Experimental gerontology
The role of stem cells and gap junctional intercellular communication in carcinogenesis.2003
A theoretical review proposed that both adult stem cells and the loss of gap junction communication between cells play central roles in cancer development, integrating existing laboratory findings rather than reporting new data.
Trosko JE -- Journal of biochemistry and molecular biology
Identification and quantification of zeaxanthin esters in plants using liquid chromatography-mass spectrometry.2003
Using mass spectrometry, researchers identified and measured zeaxanthin esters in wolfberry, Chinese lantern, orange pepper and sea buckthorn, finding these plants to be valuable sources for producing stable zeaxanthin extracts.
Weller P; Breithaupt DE -- Journal of agricultural and food chemistry
Antioxidative activities of volatile extracts from green tea, oolong tea, and black tea.2003
In laboratory oxidation assays, volatile extracts from green tea showed the strongest antioxidant activity, nearly stopping fat oxidation over 40 days, while roasted green tea extract showed the weakest effect and some pro-oxidant behavior.
Yanagimoto K; Ochi H; Lee KG; Shibamoto T -- Journal of agricultural and food chemistry
Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites.2002
In a US case-control study of 209 men with prostate cancer and 228 controls, higher blood lycopene was linked to lower prostate cancer risk in both Black and White men, and Black men had lower average blood lycopene overall.
Vogt TM; Mayne ST; Graubard BI; Swanson CA; Sowell AL; Schoenberg JB -- American journal of epidemiology
Morbidity mortality paradox of 1st generation Greek Australians.2002
An observational study of aging Greek immigrants in Australia found they kept lower cardiovascular death rates than Australian-born peers despite high risk factors, alongside more than double the blood carotenoid levels, especially lutein, from traditional diets.
Kouris-Blazos A -- Asia Pacific journal of clinical nutrition
Antioxidant activity of prune (Prunus domestica L.) constituents and a new synergist.2002
Laboratory analysis of prune extract identified antioxidant compounds including a new synergist chemical, and found the fruit's overall antioxidant activity in a test tube assay depended mainly on its caffeoylquinic acid content.
Kayano S; Kikuzaki H; Fukutsuka N; Mitani T; Nakatani N -- Journal of agricultural and food chemistry
Protective effect of colored rice over white rice on Fenton reaction-based renal lipid peroxidation in rats.2002
In rats given a kidney-damaging iron compound, diets including red or black rice prevented the rise in kidney lipid peroxidation seen with white rice, an effect that scaled with how much colored rice was fed.
Toyokuni S; Itani T; Morimitsu Y; Okada K; Ozeki M; Kondo S -- Free radical research
Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients.2002
Using a laser scan of the retina in 220 normal and 93 AMD-affected human eyes, macular lutein and zeaxanthin levels fell with age and were 32% lower in AMD eyes unless patients took high-dose lutein supplements.
Bernstein PS; Zhao DY; Wintch SW; Ermakov IV; McClane RW; Gellermann W -- Ophthalmology
Structural characterization of the glycan part of glycoconjugate LbGp2 from Lycium barbarum L.2001
Laboratory structural analysis identified the carbohydrate backbone and composition of an immune-active glycoconjugate called LbGp2 purified from wolfberry fruit, describing its chemistry rather than testing any effect in animals or people.
Peng X; Tian G -- Carbohydrate research
Inverse associations between plasma lycopene and other carotenoids and prostate cancer.2001
In a case-control study of 65 prostate cancer patients and 132 controls, higher blood levels of lycopene and zeaxanthin were linked to lower prostate cancer risk, while alpha- and beta-carotene, retinol and tocopherols showed no clear association.
Lu QY; Hung JC; Heber D; Go VL; Reuter VE; Cordon-Cardo C -- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy.2001
In 26 men with localized prostate cancer given lycopene or no supplement for 3 weeks before surgery, the lycopene group had fewer positive surgical margins and less high-grade pre-cancerous tissue, though the trial was too small for firm conclusions.
Kucuk O; Sarkar FH; Sakr W; Djuric Z; Pollak MN; Khachik F -- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study.2001
In 480 adults followed 18 months, higher blood lutein was linked to less progression of artery wall thickening, and in mouse models lutein supplementation reduced atherosclerotic lesion size by over 40 percent in two genetic strains.
Dwyer JH; Navab M; Dwyer KM; Hassan K; Sun P; Shircore A -- Circulation
Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries.2001
In blood samples from 349 healthy nonsmoking adults across five European countries, carotenoid and vitamin C and E levels varied by region, establishing reference ranges rather than testing any intervention or health outcome.
Olmedilla B; Granado F; Southon S; Wright AJ; Blanco I; Gil-Martinez E -- The British journal of nutrition
Effect of natural phenolic acids on DNA oxidation in vitro.2001
In vitro tests using fish sperm DNA, several natural phenolic acids from food protected against iron- and peroxide-induced DNA oxidation, while two related compounds showed no protection and one actually increased oxidative DNA damage.
Lodovici M; Guglielmi F; Meoni M; Dolara P -- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Balanced by design -- we show supporting and contradicting findings. Search all studies
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. g3 Juice is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what g3 Juice pairs with for each. Nothing works in isolation; these share the same systems.
For Epigenetics
For Eyes
For Gut Health
For Immune
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Drink one serving of about 60 mL daily, on its own or with a meal. Because it contains fruit concentrates, treat it as a supplement to whole fruit, not a replacement.
Where to get it
We are lining up the best way to get this one to you. In the meantime, reach out and we will point you the right way -- or browse the full shop to see every product.
See the full shopThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
g3 Juice is a juice blend built around four pigment- and polyphenol-rich fruits -- gac, cili, sea buckthorn, and Chinese lycium -- rounded out with pear, grape, and apple. It draws on a plant-medicine heritage as a whole-fruit way to take in antioxidants. It fits people who like their antioxidants the way nature packages them.
FAQ
What does g3 Juice support?
It supports the body's normal antioxidant defenses and healthy cellular aging as part of a balanced diet, provides plant pigments and polyphenols from deeply pigmented fruits, and complements a diet rich in whole fruits and vegetables.
How do I take it?
Drink one small serving daily, on its own or with a meal. Because it contains fruit concentrates, treat it as a supplement to whole fruit, not a replacement.
What makes it different?
These four fruits are genuinely pigment-rich. It contains fruit concentrates rather than whole fruit and fiber, so it is framed as tasty antioxidant support that complements real fruit.