$75.00
Your discount applies with code HOLISTICLOVE.
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What it is
A calm-support blend of saffron (Crocus sativus), honokiol from magnolia bark, and a GABA-producing probiotic strain. Saffron and its carotenoids act on mood pathways, honokiol interacts with the GABA system for calm, and the probiotic reflects the newer gut-brain angle on GABA. It is built to take the edge off overstimulation while keeping you clear-headed rather than sedated.
Why the evidence supports it
Saffron is the strongest card in this blend -- systematic reviews of randomized trials find it shows real promise for mood and calm, which is more than most stress formulas can claim. Honokiol adds a mechanism-plausible calming action on the GABA system, though much of its data is still pre-clinical, and the GABA-producing probiotic reflects a newer gut-brain idea held more loosely. Together they serve the Mind world's Regulate function -- nudging the nervous system toward a settled state. Framed as everyday calm support, not a treatment for anxiety.
What it supports
- Supports a calm, settled nervous system
- Supports steady mood during busy, overstimulating days
- Aims for calm without heavy sedation
- Combines saffron, honokiol, and a calming probiotic strain
Which function it supports
Ties to the Mind world's Regulate function -- supporting the nervous system's shift toward a calmer, more settled state.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (3 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Label revision label image on the product page, read 2026-09-11Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 3 capsules | Amount | % DV |
|---|---|---|
| Modified Citrus Pectin | 2000 mg | † |
| Magnolia Bark ExtractMagnolia officinalis, standardized to 98% honokiol | 200 mg | † |
| L. plantarum LP815 | 5 Billion CFU | † |
| Saffron Extractstandardized to 2% safranal and 3% crocin | 28 mg | † |
| Kanna ExtractSceletium tortuosum, standardized to 5% alkaloids | 12.5 mg | † |
- Servings per container:
- 30
- Other ingredients:
- Vegetarian capsule (hypromellose, water), bamboo extract.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Anti‐biofilm and bactericidal effects of magnolia bark‐derived magnolol and honokiol on <i>Streptococcus mutans</i>
Microbiology and Immunology · 2016
In cell culture, ABSTRACT Dental caries affects people of all ages and is a worldwide health concern
- Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice
J Pharm Pharmacol · 1999
Repeated honokiol dosing produced an anxiolytic-type effect in mice without the motor and muscle-relaxant side effects seen with diazepam at an anxiolytic-equivalent dose.
- Studies on the active principles of magnolia bark. Centrally acting muscle relaxant activity of magnolol and honokiol
Jpn J Pharmacol · 1975
Early pharmacology work identified magnolol and honokiol as the magnolia bark compounds behind a centrally-acting, muscle-relaxing calming effect in animal models.
- Honokiol Targeting SIRT3: From Molecular Mechanisms to Therapeutic Opportunities.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
Honokiol activates SIRT3, and this review examines the biological functions and signaling pathways of this activation across various disease models.
- EXPRESS: Honokiol and analgesia: a mechanistic review on the current capacities and challenges
2025
In a review, Pain is an unfavorable subjective sensation influencing 20% of the public population, giving rise to substantial health and economic issues
- The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms.
Current molecular pharmacology · 2023
This review examines the signal pathways and molecular mechanisms underlying the neuropharmacological effects of magnolol and honokiol compounds.
Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives.EmergingExpert review2026
An expert review on Magnolia/honokiol found that these effects are mediated through modulation of key cancer-associated signaling pathways, including PI3K/Akt/NF-κB, MAPK/JNK, ERK, TGF-β/Smad, and caspase-dependent apoptotic pathways.
Tuli HS; Pal D; Chauhan R; Sood A; Mehrotra A; Chauhan A; Bhatia R; Haque S; Sak K; Kaur D -- Seminars in oncology
Displaced minds: ecologies of depressionEmergingExpert review2026
A journal issue collected work on magnolol's antidepressant-like effects in chronic stress models, short-chain fatty acids as biomarkers in major depression, and developmental origins of cardiovascular-kidney-metabolic syndrome.
Kattner AA -- Biomedical journal
Antibacterial, Photoprotective, Anti-Inflammatory, and Selected Anticancer Properties of Honokiol Extracted from Plants of the Genus <i>Magnolia</i> and Used in the Treatment of Dermatological Problems-A ReviewEmergingExpert review2025
In a review, honokiol showed antibacterial, photoprotective and anti-inflammatory activity plus suppression of highly metastatic melanoma, with nanocarrier delivery named as the practical obstacle.
Mirosława Chwil; Katarzyna Dzida; Paulina Terlecka; Daniela Gruľová; Renata Matraszek-Gawron; Karol Terlecki; Anna Kasprzyk; Mikołaj Kostryco
Honokiol Targeting SIRT3: From Molecular Mechanisms to Therapeutic Opportunities.EmergingExpert review2025
Honokiol activates SIRT3, and this review examines the biological functions and signaling pathways of this activation across various disease models.
Xiang F; Zhang Z; Li Y; Xia B; Liao Y; Yang C; He Z; Lin L; Xie J -- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Honokiol antagonizes cadmium-induced ultrastructural nuclear variation and mitochondrial dysfunction of hepatocytes through targeting Bax proteinEmerging2026
In day-old broilers given 50 mg/L cadmium for 42 days, 50 mg/kg honokiol preserved hepatocyte nuclear and mitochondrial structure, raised superoxide dismutase and glutathione peroxidase, lowered malondialdehyde, and reduced caspase-3 expression.
Aftab Shaukat; Irfan Shaukat; Mohammed Al-Rasheed; Rizwan Shukat; Ghadeer M Albadrani; Amany A Sayed; Mohamed M Abdel-Daim; Ren-Wei Su; Zhiwen Wu
Magnolol suppresses TKI-resistant EGFR-mutant lung cancer by inhibiting EGFR and AXL-cMyc.2026
In EGFR-mutant lung cancer cell models, including osimertinib-resistant lines, magnolol from magnolia bark inhibited EGFR phosphorylation, suppressed AXL-cMyc signaling, and impaired DNA repair by downregulating Rad51.
Chen CC; Wang TH; Leu YL; Chan CW; Chen YX; Chu YD; Chen CY -- European journal of pharmacology
Protocol for Studying Honokiol Regulation of Transforming Growth Factor Beta 1/Smad Signaling in Ultraviolet A-induced Skin Photoaging Models.EmergingTrial registry2026
A trial registry on Magnolia/honokiol found that HNK has the potential to be a drug for ameliorating photo-aging damage by reducing MMP expression through activation of the TGF-β1/Smad pathway, thereby inhibiting UVA-induced photo-aging in HDF cells and mouse skin.
Ma G; Liu Z; Li Y; Tao Y -- Journal of visualized experiments : JoVE
Targeting the NAD+-SIRT3 axis to mitigate metabolic memory in diabetic kidney disease.2026
A review found that the NAD+-SIRT3 axis serves as a mechanistic hub linking mitochondrial dysfunction to inflammation and epigenetic changes in diabetic kidney disease, with reduced renal SIRT3 activity driving metabolic memory of injury.
Zhang Y; Wang Y; Qiao Y; Liu L; Zhao H; Jin Q; Peng L; Li P -- Renal failure
Using Lignans from <i>Magnolia officinalis</i> Bark in the Assessment of the Quality of Dietary Supplements-The Application of <sup>1</sup>H NMR and HPLC-DADEmergingPrimary research (design unspecified)2025
Using 1H NMR to assay Magnolia officinalis bark lignans, a significant difference was found between the actual and declared composition of commercial supplements.
Paweł Siudem; Aleksandra Wasiak; Agnieszka Zielińska; Violetta Kowalska; Katarzyna Paradowska
Magnolia officinalis (L.) Bark Extract Counteracts Oxidative Brain Injury: A Proteomic Investigation into Neuroprotective Mechanisms.2026
In rat brain cortical slices exposed to hydrogen peroxide-induced oxidative stress, Magnolia officinalis bark extract restored tissue viability, reduced ROS and malondialdehyde levels, and reduced activation of caspase-3, -8, and -9 apoptotic pathways.
Mattioli LB; Stella R; Peggion C; Cagnin S; Pifferi A; Miraldi E; Cappellucci G; Baini G; Camarda L; Budriesi R; Frosini M -- International journal of molecular sciences
Magnolol Ameliorates Cisplatin-Induced Acute Kidney Injury with Activation of Nrf2-Associated Antioxidant Responses.EmergingAnimal study2026
An animal study on Magnolia/honokiol found that apoptotic damage was mitigated, as shown by the fewer TUNEL-positive cells and lowered expression of pro-apoptotic markers.
Gwon MG; Park MH; Leem J -- Current issues in molecular biology
Sex-specific hearing loss in Sirt3 knockout mice and attenuation by honokiol.ContestedAnimal study2026
An animal study on Magnolia/honokiol found that this study demonstrates that SIRT3 is required for hearing function and that honokiol attenuates hearing loss and oxidative stress in male Sirt3-/- mice.
Koo C; Zhou Y; Thomas D; Fuentes R; Li J; Kim M; Richter CP; Tan X -- Hearing research
The Anti-Glioblastoma Effects of Magnolol Are Mediated through Paradoxical Enhancement of Antioxidant Defenses and Induction of Apoptosis.EmergingPreclinical study2026
A preclinical study on Magnolia/honokiol found that this novel mechanism highlights its potential as a research subject of interest.
Zand M; Latifi SA; Salehi M; Karami H -- Cell journal
Laccase-Catalyzed Dimerization of Honokiol and Magnolol for Multitarget Metabolic Enzyme Inhibitors.ContestedPreclinical study2026
A preclinical study on Magnolia/honokiol found that the dimers exhibited more potent inhibitory activity than honokiol and magnolol, with houpulin B showing the strongest inhibition toward all tested enzymes.
Sciacca C; Cardullo N; Pulvirenti L; Varriale S; Vitiello L; Pezzella C; Muccilli V -- Chembiochem : a European journal of chemical biology
Synergistic Effects of Honokiol on Camptothecin-triggered Apoptosis of Drug-resistant Glioblastoma Cells via CDK1-mediated G2/M Arrest and Intrinsic ROS-Mitochondrion-dependent Pathway.EmergingAnimal study2026
An animal study on Magnolia/honokiol found that our previous studies showed the benefits of CPT and CPT-containing nanoparticles on suppressing GBM tumorigenesis.
Yang CP; Chen JT; Liu SH; Chen E; Chen RM -- Anticancer research
Honokiol Ameliorates Hepatic Lipid Accumulation by Deacetylating PPARG via SIRT3.EmergingPreclinical study2026
A preclinical study on Magnolia/honokiol found that this study suggests that HKL ameliorates hepatic lipid accumulation via SIRT3-mediated deacetylation of PPARG, providing an experimental basis for considering HKL as a research subject of interest against metabolic disorders.
Yang Y; Guo S; Luo W; Liu D; Kang X -- Cells
Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells.EmergingPreclinical study2026
A preclinical study on Magnolia/honokiol found that these interactions suggest that MRW constituents' function as non-nucleoside DNMT-1 inhibitors and ROS-immune modulators that disrupt oncogenic feedback loops and re-activate apoptotic pathways.
Choi J; Lee HS; Kim HJ; Choi M; Tallei TE; Ahn CH; So JH; Park MN; Kim B -- Fitoterapia
Magnolol mitigates polystyrene microplastic-induced oviductal toxicity in laying hens via immunomodulation and microbiota regulation.EmergingAnimal study2026
An animal study on Magnolia/honokiol found that dietary MAG mitigates PS-induced oviductal damage through immunomodulation and microbiota regulation, ultimately improving reproductive performance in laying hens.
Lv Y; Huang W; Ge C; Wu L; Hu Z; Zhan S; Shen X; Yu D; Liu B -- Poultry science
Mitochondrion-targeted magnolol derivatives exert synergistic anticancer activity by modulating energy metabolism and tumor microenvironment.EmergingPreclinical study2026
A preclinical study on Magnolia/honokiol found that this study demonstrates that mitochondrion-targeted MTP is far more effective than magnolol to kill cancer cells.
Wang Y; Zhang J; Tan Y; Jiang S; Tong M; Wang X -- European journal of medicinal chemistry
Honokiol attenuates neuroinflammation and enhances remyelination in mouse models of multiple sclerosis through PPARγ-mediated ERK/AKT signalling.EmergingPreclinical study2026
A preclinical study on Magnolia/honokiol found that honokiol improved myelin restoration and exerted potent anti-inflammatory effects by suppressing glial activation, modulating inflammatory cytokine profiles, and restoring lipid homeostasis.
Yu X; Wei L; Zheng Y; Qi X; Mu X; Wang Q; Hua Y; Chen Q; Zhang Y; Jiang H; Wang Z; Ni P -- Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Deciphering the multi-target mechanism of Magnolia officinalis in irritable bowel syndrome with diarrhea: A combined network pharmacology, machine learning, and in vivo validation studyEmergingAnimal study2026
Computational screening of Magnolia officinalis identified magnolol, honokiol and obovatol acting on eight targets including EGFR and MET, and in mice they reduced anxiety-like behaviour, intestinal hypermotility and serum IL-8.
Xiran Wang; Yuli Wei; Mengze Wang; Yu Zhang; Longfei Liu; Xiaokai Ma; Li Gao; Haixia Ji
Magnolol targets CCND1 to suppress the proliferation of cholangiocarcinoma cells by inhibiting the Akt and STAT3 pathways.EmergingAnimal study2026
An animal study on Magnolia/honokiol found that magnolol exerted its effect on arresting the cell cycle at the G0-G1 phase through suppressing CCND1, suggesting that magnolol holds potential as a novel anti-CCA agent.
Luo W; Meng Z; Li S -- Toxicology and applied pharmacology
Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation.EmergingAnimal study2026
An animal study on Magnolia/honokiol found that these findings suggest a previously unrecognized SIRT3-CYC1 signaling axis underlying honokiol's mitochondrial protective effects in AP.
Miao YF; Yao JQ; Peng Y; Bai D; Fan SH; Li HY; Jin W; Lu Y -- Journal of integrative medicine
Targeting YAP-TEAD Interaction with Honokiol to Inhibit Melanoma Progression and Metastasis.EmergingPreclinical study2026
In mouse melanoma models, the honokiol derivative HK03 blocked the YAP-TEAD protein interaction, reduced tumor cell migration and EMT markers, and lowered metastatic tumor burden in the lungs.
Lee C; Do HTT; Fei X; Lee S; Hyun S; Seo SY; Rhee I -- Biomolecules & therapeutics
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
via Saffron · 10 studies, 8 in people
What people often notice when this marker sits outside the usual range
Higher: The symptoms that actually travel with raised triglycerides belong to the metabolic pattern behind them -- the post-meal crash, central weight, rising blood pressure, fatty liver.
Lower: Very low total cholesterol alongside low albumin and unintended weight loss points at absorption or liver capacity, not at good health.
- Glucose (Fasting)solid evidence
via Saffron · 8 studies, 7 in people
What people often notice when this marker sits outside the usual range
Higher: Waking at 3am, often with a racing heart -- 'why do i wake up at 3am every night'.
Lower: Shakiness, sweating, sudden anxiety and difficulty concentrating that resolve within minutes of eating.
- Hemoglobin A1c (HbA1c)solid evidence
via Saffron · 7 studies, 6 in people
What people often notice when this marker sits outside the usual range
Higher: Everything listed under fasting glucose, but with more time behind it -- HbA1c is a three-month average, so symptoms are usually established rather than new.
- High-Sensitivity C-Reactive Protein (hs-CRP)solid evidence
via Saffron · 5 studies, 4 in people
Systematic review and meta-analysis on inflammation and oxidative stress specifically -- reduced inflammatory markers.
What people often notice when this marker sits outside the usual range
Higher: Deep, unrefreshing fatigue -- searched as 'tired all the time blood tests normal' and 'why am i tired even after 8 hours sleep'.
Lower: No symptoms. Low is the desirable direction.
- Fasting Glucoseemerging evidence
via Saffron · 8 studies, 7 in people
What people often notice when this marker sits outside the usual range
Higher: A high fasting glucose is often silent early -- the classic high-sugar symptoms (excess thirst, frequent urination, fatigue, blurred vision) tend to appear later and higher.
Lower: A genuinely low glucose (hypoglycaemia) can cause shakiness, sweating, irritability, hunger and lightheadedness -- but a low-normal fasting value in a healthy person is usually favourable.
- HbA1c (Hemoglobin A1c)emerging evidence
via Saffron · 7 studies, 6 in people
What people often notice when this marker sits outside the usual range
Higher: A high HbA1c reflects the same chronic high-glucose state -- silent early, then thirst, frequent urination and fatigue at higher levels.
Lower: A low HbA1c is generally favourable, but an unexpectedly low value can reflect a red-cell condition rather than excellent control -- cross-check against fasting glucose if it surprises you.
- HbA1c (Glycated Hemoglobin)emerging evidence
via Saffron · 7 studies, 6 in people
What people often notice when this marker sits outside the usual range
Higher: A high HbA1c reflects the same chronic high-glucose state as glucose, averaged over roughly three months -- silent early, then thirst, frequent urination and fatigue at higher levels.
Lower: A low HbA1c is generally favourable, but an unexpectedly low value can reflect a red-cell condition rather than excellent control -- cross-check against fasting glucose if it surprises you.
- hs-CRP (High-Sensitivity C-Reactive Protein)emerging evidence
via Saffron · 5 studies, 4 in people
What people often notice when this marker sits outside the usual range
Higher: A high hs-CRP reflects low-grade inflammation SOMEWHERE -- you tend to feel the underlying cause (a cold, a flare, a sore joint, poor sleep, extra weight) rather than the CRP itself.
Lower: A low hs-CRP is favourable and simply reflects little systemic inflammation at the moment of the draw.
- hs-CRP (High-Sensitivity C-Reactive Protein)emerging evidence
via Saffron · 5 studies, 4 in people
What people often notice when this marker sits outside the usual range
Higher: hs-CRP is non-specific -- read it as a trend and in context, never as a stand-alone verdict.
Lower: A low hs-CRP is favourable and simply reflects little systemic inflammation at the moment of the draw.
- Cortisolemerging evidence
via GABA (+ psychobiotic) · 11 studies, 3 in people
What people often notice when this marker sits outside the usual range
Higher: "Wired but tired" -- exhausted all day, then alert the moment the head hits the pillow.
Lower: Profound fatigue that is worst in the morning, and improves slightly through the day -- the reverse of the usual pattern.
- HDL Cholesterolemerging evidence
via Saffron · 3 studies, 3 in people
What people often notice when this marker sits outside the usual range
Higher: Silent, and NOT automatically good news.
Lower: Silent. HDL produces no sensation at any level.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Tranquil Mind is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Tranquil Mind pairs with for each. Nothing works in isolation; these share the same systems.
For Brain & Sleep
For Mood & Hormones
For Women's Health
For Gut Health
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Take with water, either during a demanding stretch of the day or in the evening to wind down, depending on how it sits with you. Follow the brand's serving size.
Use code HOLISTICLOVE at checkout.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get Tranquil MindThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Tranquil Mind is a calm-support blend of honokiol (from magnolia bark), saffron, and a GABA-producing probiotic strain. It is built to help take the edge off overstimulation while keeping you clear-headed rather than sedated. It fits people who want to feel settled without the fog.
FAQ
What does Tranquil Mind support?
It supports a calm, settled nervous system and steady mood during busy, overstimulating days, aims for calm without heavy sedation, and combines saffron, honokiol, and a calming probiotic strain.
How do I take it?
Take with water, either during a demanding stretch of the day or in the evening to wind down, depending on how it sits with you. Follow the brand's serving size.
What makes it different?
Saffron and magnolia bark both have real, if modest, human calm-and-mood research behind them. It is framed as everyday nervous-system support for feeling settled, not a treatment for anxiety.