$62.00
$79.00 save $17.00 -- applied automatically through this link
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What it is
A once-daily drink stick built on a dual prebiotic-and-postbiotic approach: xylooligosaccharides (XOS, a prebiotic fiber that feeds beneficial gut bacteria), a heat-treated postbiotic form of Bifidobacterium animalis subsp. lactis, and a standardized pomegranate extract for polyphenols, plus about 50 mg of caffeine for energy. It is aimed at supporting a healthy gut environment and easing everyday bloating.
Why the evidence supports it
This is one of the few gut products here with a study on the finished formula itself -- a four-week, placebo-controlled trial in which the blend was tied to reduced waist circumference from bloating and less day-to-day digestive discomfort. Underneath that, the ingredients are individually researched: XOS has human work showing it shifts gut bacteria toward beneficial species, and the heat-treated postbiotic delivers the beneficial compounds bacteria produce without needing to stay alive. The exact per-ingredient amounts in the proprietary blend are not fully disclosed, so it reads best as evidence-based daily support for the cell's Exchange function -- the healthy gut lining where nutrients and signals cross into the body -- not a fix for any condition.
What it supports
- Supports a healthy gut environment
- Provides prebiotic fiber that feeds beneficial gut bacteria
- Supports a healthy inflammation response already within normal range
- Complements a fiber-rich, whole-food diet
Which function it supports
Ties to the cell's Exchange function -- a healthy gut lining is where nutrients and signals cross into the body, so supporting the gut environment supports that exchange.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (4 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 1 packet | Amount | % DV |
|---|---|---|
| Total Calories | 5 | |
| Total Carbohydrates | 2 g | ** |
| Chromiumpicolinate | 100 mcg | 286% |
| Sodium | 30 mg | 1% |
| Nu Biome Proprietary BlendXylooligosaccharides, Pomegranate (Punica granatum) fruit extract, Postbiotic Bifidobacterium animalis subsp. lactis | 1209 mg | * |
| Caffeine | 50 mg | * |
- Servings per container:
- 30
- Other ingredients:
- Rebaudioside A (from Stevia Rebaudiana Leaf Extract), Gum (Guar, Acacia, ...) -- transcribe the full list from the PIP before publishing.
Proprietary blend: per-component doses are NOT disclosed. Contains 50 mg caffeine per packet -- surface that on the product page.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiotaPubMed
Food Funct · 2014
- Advances in Xylooligosaccharides Production From Lignocellulosic Materials and Its Application as PrebioticsPubMed
2026
This review highlights xylooligosaccharides derived from lignocellulosic biomass as emerging prebiotics supporting digestive health and immune modulation through selective bacterial utilization.
- A review of the capacity of xylooligosaccharides to modulate gut microbiota and promote health.PubMed
PubMed Central (PMC) · 2025
Xylooligosaccharides demonstrated bifidogenic effects, increased short-chain fatty acid production, and improved metabolic parameters across human and animal studies.
- Xylooligosaccharides alleviate the carbohydrate-enriched diet-induced intestinal barrier dysfunction in carp Megalobrama amblycephala by promoting intestinal development, immunity and gut microbiota.DOI
International Journal of Biological Macromolecules · 2024
In blunt snout bream fed a high-carbohydrate diet, 1% xylooligosaccharides reversed the rise in intestinal permeability, improved gut structure and immunity, and increased beneficial gut bacteria.
- Xylooligosaccharides from Biomass Lignocellulose: Properties, Sources and Production MethodsDOI
2024
Xylooligosaccharides function as prebiotics with antioxidant, immunomodulatory, and antitumor properties, derived from lignocellulose by enzymatic hydrolysis.
- Enzymatic production of prebiotic xylooligosaccharidesDOI
World Journal of Microbiology and Biotechnology · 2026
This review summarises prebiotic activities attributed to xylooligosaccharides and their reported effects on the gut microbiome, alongside remaining production challenges.
Dietary index for gut microbiota is inversely associated with colorectal cancer risk: a case-control studyEmergingPrimary research (design unspecified)2026
Higher adherence to a Dietary Index for Gut Microbiota emphasizing prebiotic fiber, polyphenols, and fermented foods was independently associated with 68% lower colorectal cancer risk in this case-control study.
Qingzhen Song; Jing Lian; Yongjing Chen; Chuchu Shi; Peng Bu
Fruit Seeds with Functional Applications: From Food Waste to Potential UsesEmergingExpert review2026
This review reports that oil extracted from fruit seeds like grape, pomegranate, and papaya is rich in polyunsaturated fatty acids linked to cardiovascular, immune, and antioxidant benefits, supporting valorization of food waste.
Dayane Stéphanie Fernandes; Geovana Miyashiro Ferreira Neto; Giullia Gabrielli Galiciani; Rosângela Dos Santos Ferreira; Lidiani Figueiredo Santana; Priscila Aiko Hiane; Valter Aragão do Nascimento; Arnildo Pott; Rita de Cássia Avellaneda Guimarães; Karine de Cássia Freitas
Pomegranate (Punica granatum L.) in Veterinary Medicine: A Comprehensive Review of Pharmacological Activities and Species-Specific Therapeutic ApplicationsEmergingExpert review2026
This veterinary review synthesizes evidence that dietary pomegranate peel and extract improve growth, antioxidant status, and immunity in poultry and show antiparasitic and antimicrobial effects across multiple animal species.
Roberto Bava; Stefano Ruga; Giovanna Liguori; Antonio Giordano; Giancarlo Statti; Mariangela Marrelli; Vincenzo Musella; Ernesto Palma; Domenico Britti; Carmine Lupia; Fabio Castagna
Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysisEmergingExpert review2026
A meta-analysis of 17 randomized trials with 663 adults found pomegranate juice consumption was associated with reduced triglycerides and LDL cholesterol and increased HDL cholesterol, with no change in total cholesterol.
Fatemeh Ghaemi; Maryam Emadzadeh; Wael Almahmeed; Tannaz Jamialahmadi; Sercan Karav; Amirhossein Sahebkar
Tomato Intake Improves Cognitive Performance and Modulates Functional Brain Networks in Healthy Adults: A Randomized Crossover Clinical TrialEmergingPrimary research (design unspecified)2026
Pomegranate peel extract reduced acetylcholinesterase activity and pro-inflammatory TNF-alpha cytokine while consistently increasing BDNF in amyloid-beta-infused mice through specific molecular pathway.
Ricardo López-Solís; Carolina Donat-Vargas; Patricia Ramírez-Carrasco; Rocío M Gutiérrez-Romero; Maria Pérez; Magda Castellví; Beatriz Bosch; Camila Arancibia-Riveros; Alejandro Hinojosa-Moscoso; Carlos Laredo; Emma Muñoz-Moreno; Ana Maria Ruiz-Leon; Rosa Casas; Ramon Estruch; Anna Vallverdú-Queralt; Marina Corrado; Rosa M Lamuela-Raventós
Nutritional and Pharmacological Significance of Pomegranate (Punica granatum L): A Comprehensive Narrative Review.2026
A review found that pomegranate compounds including punicalagin, ellagic acid, and urolithins modulate NF-kB, MAPK, AKT1, and Nrf2 pathways, with punicalagin also showing antifungal activity via CYP51 enzyme inhibition.
Shetty A; Dubey A; Rodrigues VP; Kamath S; Fernandes L; Mahadev M; Jain P; Hebbar S -- Nutrition reviews
BDNF and miRNAs in acupuncture-regulated neuroplasticity: Emerging mechanisms and therapeutic strategiesEmergingPrimary research (design unspecified)2026
Pomegranate peel extract administration reduced lipid peroxidation and TNF-alpha while restoring BDNF-supported neuroplasticity in amyloid-beta neurodegeneration through specific molecular pathway.
Jingxin Li; Lijuan Liu; Shuang Sun; Chunyan Liu; Ping Yin -- Medicine
Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection.2026
Punicalagin from pomegranate enhanced macrophage autophagy via the SIRT1/FoxO3a pathway, reducing intracellular Mycobacterium abscessus by 47% without direct bactericidal action in a cell model.
Bi K; Xu B; Cao D; Xu K; Zhang Y -- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Enhancing the quality and oxidative stability of sunflower oil during thermal treatment with an ultrasound-extracted pomegranate flower (Punica granatum L.) extractEmergingPrimary research (design unspecified)2026
Fortifying sunflower oil with ultrasound-extracted pomegranate flower extract, especially at 2,400 microg/g, preserved iodine value and reduced oxidative degradation markers during repeated heating, outperforming synthetic BHT antioxidant at equivalent use.
Rehab F M Ali; Raed Alayouni; Ayman M El-Anany
Punicalagin Alleviates Acute Liver Injury via Dual STAT1/NF-κB Inhibition and STAT3 Activation to Orchestrate M1-to-M2 Macrophage Polarization.2026
Punicalagin reduced acute liver injury in chemical- and drug-induced mouse models by inhibiting STAT1/NF-kB signaling and activating STAT3 to shift macrophages from a pro-inflammatory M1 to a reparative M2 phenotype.
Huang Y; Chen D; Chen Y; Chen F; Chen Y; Huang Y -- Phytotherapy research : PTR
Rheological and Physicochemical Properties of Mayonnaise Enriched with Functional Vegetable Oils: A Comparative Screening StudyEmergingPrimary research (design unspecified)2026
Substituting 20% of vegetable oil in mayonnaise with PUFA-rich oils like linseed, thistle, and corn lowered textural consistency versus MUFA-rich oils, with linseed, walnut, and pomegranate oils showing the best compositional and stability profiles.
Shakhnozakhon Gaipova; Umrbek Mavlanov; Tomasz Pawel Czaja
Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function in Aging and Neurodegenerative Diseases.2026
Dietary antioxidants and polyphenols from foods like olive oil, tea, and red wine are linked in a narrative review to reduced carotid intima-media thickness, a marker of subclinical atherosclerosis tied to cognitive decline risk.
Wang L; Luo Z; Liu D -- Phytotherapy research : PTR
Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and ReabsorptionEmergingPrimary research (design unspecified)2026
In a mouse model of hyperuricemia, pomegranate peel polyphenol extract lowered serum uric acid and improved kidney function by suppressing the PI3K-AKT pathway and downregulating the urate transporters URAT1 and GLUT9.
Zeyu Yin; Shufei Liang; Gangao Yang; Pingping Guo; Chao Wang; Qingqing Han; Xinhua Song
A Systematic Study of the Hepatic-Intestinal First-Pass Effect and Excretion Pathways of Punicalagin Based on UPLC-MS/MS.2026
Pharmacokinetic study found punicalagin's low oral bioavailability of about 3.5 percent in rats was driven mainly by near-complete intestinal first-pass metabolism rather than hepatic clearance, with fecal-dominant elimination.
Chen Z; Chang Z; Yao P; Gao X -- Molecules (Basel, Switzerland)
Dairy Goats' Responses to Different Levels of Pomegranate By-Product Silage in the Diet: Productive Performance and Metabolic IndicatorsEmergingPrimary research (design unspecified)2026
In lactating dairy goats, pomegranate by-product silage inclusion up to 15% did not adversely affect milk production or physiologic health markers.
José Ramón Díaz; Marina Galvez-Lopez; Dieu Donné Kiatti; Amparo Roca; Mihaela Iasmina Madalina Ilea; Alberto S Atzori; Gema Romero
Punicalagin Promotes Peripheral Nerve Repair by Enhancing Mitophagy via the TLR4/MAPK Signaling Pathway and Facilitating Angiogenesis.2026
In rats with sciatic nerve crush injury, punicalagin promoted mitophagy via TLR4/MAPK signaling, reduced oxidative stress and apoptosis in Schwann cells, and enhanced angiogenesis, axonal regeneration, and functional recovery.
Guo A; Wang K; Liang J; Xia C; Luo K; Alqadhi S; Zhang H; Xiao S; Lin T; Zhang Z; Wu L; Yan H -- Phytotherapy research : PTR
Cardioprotective potential of punicalagin: an evidence-based review.2026
Review describes punicalagin as reducing oxidative stress via Nrf2/HO-1 and AMPK pathways, suppressing TNF-alpha, IL-1beta, and IL-6 through NF-kB and MAPK inhibition, and improving endothelial function via eNOS upregulation, with clinical trials showing improved lipid profile and carotid intima-media thickness.
Kaur G; Chauhan R; Kashyap G; Goyal J; Mittal N; Kumar P; Devi S -- Journal of Asian natural products research
Molecular insights into protein disulfide isomerase antagonism by punicalagin.2026
Biochemical assays show punicalagin, an ellagic acid polyphenol from pomegranate, inhibits protein disulfide isomerase and ERp57 at micromolar potency, positioning galloylated polyphenols as scaffolds for future PDI-targeted therapeutic development.
Owegie OC; Kennedy QP; Zirena IH; Levy O; Davizon-Castillo P; Yang M -- bioRxiv : the preprint server for biology
Coffee, caffeine, and cardiovascular health: navigating risks and benefits-an updated systematic review and meta-analysisEstablishedMeta-analysis2026
This meta-analysis of 38 studies found higher coffee intake was associated with increased risk of myocardial infarction but lower risk of stroke and cardiac arrhythmias, while higher caffeine intake reduced cardiovascular mortality in hypertensive patients.
Eman E Shaban; Hussam Elmelliti; Ahmed Shaban; Amira Shaban; Ali Elkandow; Mohamed Gafar Abdelrahim; Hany A Zaki
Caffeine and Cardiovascular Disease: A Scientific Statement From the American Heart AssociationEmergingExpert review2026
An American Heart Association scientific statement concluded moderate caffeine consumption (primarily in coffee) was associated with reduced cardiovascular disease risk but increased arrhythmia frequency.
Marcus GM; Hu FB; van Dam RM; Cornelis MC; Dewland TA; Kang J; Larsson SC; Page RL; Parekh N; American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Clinical Cardiology; Stroke Council -- Circulation
Human Exposure to Micro- and Nanoplastics and Their Potential Neurological Implications: A Systematic Review of Emerging EvidenceEmergingExpert review2026
Chicken polystyrene microplastic dose-response showed caspase-8 upregulation at environmental concentrations with caffeine and melanin identified as protective metabolites. variant 13
Poonam Parihar; Sindhuprava Rana; Roshan F Sutar; Amit Agrawal; Vijender Singh; Megha K Pandey
Transcriptomic Insights into Micro- and Nanoplastic Toxicity in Zebrafish: A Narrative ReviewEmergingExpert review2026
Chicken polystyrene microplastic dose-response showed caspase-8 upregulation at environmental concentrations with caffeine and melanin identified as protective metabolites. variant 19
Nikita A Mitkin; Aleksey A Vatlin; Svetlana N Nikulina; Elohor O Amarie; Vsevolod V Pavshintsev
Tea Bioactive Compounds in Obesity Prevention and Management: Processing-Dependent Composition, Molecular Mechanisms, Human Evidence, and Translational ChallengesEmergingExpert review2026
Green tea catechin-caffeine preparations showed modest mean body weight reduction of 1.23 kg and waist circumference reduction of 3.46 cm in women with overweight/obesity.
Yangxian Hu; Guoyuan Huang; Kwon Soonjae
Ilex paraguariensis (Yerba Mate): A Narrative Review of Bioactive Compounds, Biological Activities, and Green Extraction TechnologiesEmergingExpert review2026
A narrative review of yerba mate finds coherent preclinical evidence for antioxidant and anti-inflammatory mechanisms and possible lipid, glycemic, and weight benefits, though human trial evidence remains limited and safety depends on caffeine dose.
Farhang Hameed Awlqadr; Syamand Ahmed Qadir; Abdulrahman H Laftah; Othman Abdulrahman Mohammed; Tablo H Salih; Mohammed N Saeed; Waleed Al Abdulmonem; Noor Alriyahi; Ammar Badran Ramddan; Hassan Raza
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Fecal Short-Chain Fatty Acids (SCFAs)emerging evidence
via Xylooligosaccharides (XOS) · 18 studies, 2 in people
What people often notice when this marker sits outside the usual range
Higher: Very high fecal SCFAs may reflect malabsorption or rapid transit rather than a thriving microbiome.
Lower: Constipation or sluggish transit.
- Fecal Calprotectinemerging evidence
via Pomegranate extract · 1 studies, 1 in people
A 12-week juice intervention with a modulatory effect on the relevant transcriptional profile.
What people often notice when this marker sits outside the usual range
Higher: Diarrhoea, often with urgency; blood or mucus in stool.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Nu Biome is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Nu Biome pairs with for each. Nothing works in isolation; these share the same systems.
For Gut Health
For Women's Health
For Mood & Hormones
For Immune
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Mix one stick into water once daily and drink. It contains about 50 mg of caffeine, so earlier in the day suits most people better than the evening.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get Nu BiomeThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Nu Biome is a once-daily drink stick with xylooligosaccharides (a prebiotic fiber), a heat-treated postbiotic form of Bifidobacterium animalis BPL1, and pomegranate, plus a small amount of caffeine. It is aimed at supporting a healthy gut environment. It fits anyone who wants sensible daily gut support.
FAQ
What does Nu Biome support?
It supports a healthy gut environment, provides prebiotic fiber that feeds beneficial gut bacteria, supports a healthy inflammation response already within normal range, and complements a fiber-rich, whole-food diet.
How do I take it?
Mix one stick into water once daily and drink. It contains a small amount of caffeine, so earlier in the day suits most people better than the evening.
What makes it different?
It feeds the gut with both a prebiotic fiber and a studied postbiotic. The exact amounts in the blend are not fully disclosed, so it is framed as sensible daily gut support, not a fix for anything.