$59.00
$75.00 save $16.00 -- applied automatically through this link
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What it is
A once-daily drink stick built on a dual prebiotic-and-postbiotic approach: xylooligosaccharides (XOS, a prebiotic fiber that feeds beneficial gut bacteria), a heat-treated postbiotic form of Bifidobacterium animalis subsp. lactis, and a standardized pomegranate extract for polyphenols, plus about 50 mg of caffeine for energy. It is aimed at supporting a healthy gut environment and easing everyday bloating.
Why the evidence supports it
This is one of the few gut products here with a study on the finished formula itself -- a four-week, placebo-controlled trial in which the blend was tied to reduced waist circumference from bloating and less day-to-day digestive discomfort. Underneath that, the ingredients are individually researched: XOS has human work showing it shifts gut bacteria toward beneficial species, and the heat-treated postbiotic delivers the beneficial compounds bacteria produce without needing to stay alive. The exact per-ingredient amounts in the proprietary blend are not fully disclosed, so it reads best as evidence-based daily support for the cell's Exchange function -- the healthy gut lining where nutrients and signals cross into the body -- not a fix for any condition.
What it supports
- Supports a healthy gut environment
- Provides prebiotic fiber that feeds beneficial gut bacteria
- Supports a healthy inflammation response already within normal range
- Complements a fiber-rich, whole-food diet
Which function it supports
Ties to the cell's Exchange function -- a healthy gut lining is where nutrients and signals cross into the body, so supporting the gut environment supports that exchange.
Learn the why behind this pillarHow it relates to your cells and mind
Every product here ties back to a specific job your body does. This one touches the functions below -- follow either link to see the mechanism in full, then dig into the studies.
What it is made of -- and the mechanisms behind it
Each ingredient acts on several of the body's functions. Taken together, this product touches these cell and mind functions -- follow any to see the mechanism in full.
The ingredients
Mechanisms drawn from our ingredient knowledge base (4 profiled ingredients). Structure and function only -- not a treatment claim.
What’s actually in it
Transcribed from the manufacturer’s official Product Information Page, exactly as printed. Ingredient names that link open our research page for that ingredient, with the studies behind it.
| Amount per 1 packet | Amount | % DV |
|---|---|---|
| Total Calories | 5 | |
| Total Carbohydrates | 2 g | ** |
| Chromiumpicolinate | 100 mcg | 286% |
| Sodium | 30 mg | 1% |
| Nu Biome Proprietary BlendXylooligosaccharides, Pomegranate (Punica granatum) fruit extract, Postbiotic Bifidobacterium animalis subsp. lactis | 1209 mg | * |
| Caffeine | 50 mg | * |
- Servings per container:
- 30
- Other ingredients:
- Rebaudioside A (from Stevia Rebaudiana Leaf Extract), Gum (Guar, Acacia, ...) -- transcribe the full list from the PIP before publishing.
Proprietary blend: per-component doses are NOT disclosed. Contains 50 mg caffeine per packet -- surface that on the product page.
Source: official Product Information Page . Amounts are the manufacturer’s, not ours. Structure and function only -- nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease.
The science on the ingredients
These studies are research on the ingredients and mechanisms in this product, not on the finished product itself, and they are shown for education. For this ingredient most of the published work is laboratory or animal research rather than human trials, so read it as biology worth knowing rather than proof of an effect in people. Nothing here is medical advice, and nothing here may be used to diagnose, treat, cure, or prevent any disease. Talk to your own provider about what is right for you.
- Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota
Food Funct · 2014
- Enzymatic production of prebiotic xylooligosaccharides
World Journal of Microbiology and Biotechnology · 2026
This review summarises prebiotic activities attributed to xylooligosaccharides and their reported effects on the gut microbiome, alongside remaining production challenges.
- The prebiotic potential of xylooligosaccharides: status, challenges, and future prospects
Food, Nutrition and Health · 2026
This review covers the status of xylooligosaccharide prebiotics, the discovery of new XOS-utilising gut bacteria, and development of XOS-based synbiotics for human nutraceutical use.
- Production of Xylooligosaccharides (XOSs) with Anti-inflammatory and Prebiotic Activities Using Recombinant Endo-1,4-β-xylanases from <i>Bacillus subtilis</i>
2026
Two recombinant Bacillus subtilis xylanases converted xylan into 53% and 51% xylooligosaccharides, over 90% of which were short chains, and the products showed prebiotic and anti-inflammatory activity in human monocytes.
- Prebiotic xylooligosaccharides ameliorate metabolic dysfunction-associated steatotic liver disease via modulating gut microbiota and metabolites
2026
In mice on a high-fat diet for 16 weeks, xylooligosaccharides at 1.0 g/kg but not 0.38 g/kg lowered serum ALT and triglycerides and reduced hepatic steatosis.
- Xylooligosaccharides ameliorate intestinal barrier injury by inhibiting apoptosis, RhoA/ROCK/MLCK signaling and NKG2DLs in intestinal epithelial cells
2026
Under the study conditions xylooligosaccharides reduced intestinal barrier injury by inhibiting apoptosis, RhoA ROCK MLCK signalling and NKG2D ligands in intestinal epithelial cells.
Pomegranate consumption on blood pressure in adultsEmergingMeta-analysis2024
Pooled systolic and diastolic pressure decreased -- Overlaps heavily with prior review (Pomegranate evidence)
Bahari H et al. -- Phytotherapy Research
Beyond the Gut: Unveiling Butyrate's Global Health Impact Through Gut Health and Dysbiosis-Related Conditions: A Narrative ReviewSystematic review2024
Butyrate, a short-chain fatty acid made by gut bacteria fermenting fiber, is the preferred fuel for colon cells and supports gut barrier integrity.
Arda Erkan Kalkan; Mona N BinMowyna; António Raposo; Md Faruque Ahmad; Faiyaz Ahmed; Abdullah Y Otayf; Conrado Carrascosa; Ariana Saraiva; Sercan Karav -- PubMed Central (PMC)
Efficacy and Safety of Lactobacillus acidophilus LA85 in Preventing Antibiotic-Associated Diarrhea: A Randomized, Placebo-Controlled StudyRandomized controlled trial2025
A specific Lactobacillus strain reduced the incidence of diarrhea associated with antibiotic use in this randomized trial.
Jianguo Zhu; Yukun Sun; Yao Dong; Yunjiao Zhao; Zhonghui Gai; Shuguang Fang -- PubMed Central (PMC)
Effects of Dietary Fiber Supplementation on Gut Microbiota and Bowel Function in Healthy Adults: A Randomized Controlled TrialRandomized controlled trial2025
Fiber supplementation improved bowel regularity and shifted gut bacteria composition in healthy adults over the trial period.
Study authors -- Microorganisms
Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation: randomized clinical trialRandomized controlled trial2024
Resistant starch supplementation increased beneficial short-chain-fatty-acid-producing bacteria and improved stool frequency in adults with chronic constipation.
Sirirat Luk-In; Chaniya Leepiyasakulchai; Chutiphon Saelee; Arisa Keeratichamroen; Nuttarat Srisangwan; Punnee Ponprachanuvut; Kantanit Chammari; Tanittha Chatsuwan; Dhammika Leshan Wannigama; Aye Mya Sithu Shein; Naris Kueakulpattana; Sukrit Srisakul et al. -- Scientific Reports
Swapping White for High-Fibre Bread Increases Faecal Abundance of Short-Chain Fatty Acid-Producing Bacteria and Microbiome Diversity: A Randomized, Controlled, Decentralized TrialRandomized controlled trial2024
A simple swap from white to high-fiber bread increased gut bacterial diversity and short-chain-fatty-acid producing bacteria in a randomized trial.
Yanan Wang; Brooke Wymond; Himanshu Tandon; Damien P Belobrajdic -- PubMed Central (PMC)
The Impact of Fermented Milk Products Containing Bifidobacterium longum BB536 on the Gut Environment: A Randomized Double-Blind Placebo-Controlled TrialRandomized controlled trial2024
Fermented milk with the probiotic strain B. longum BB536 shifted gut bacteria composition, raising beneficial Faecalibacterium levels within days.
Ryuta Ejima; Riko Mishima; Akira Sen; Kana Yamaguchi; Eri Mitsuyama; Hiroki Kaneko; Madoka Kimura; Satoshi Arai; Natsumi Muto; Akari Hiraku; Kumiko Kato; Yasuyuki Kuwano et al. -- PubMed Central (PMC)
Xylo-oligosaccharides improve functional constipation by targeted enrichment of BifidobacteriumRandomized controlled trial2024
XOS prebiotic supplementation improved constipation scores and enriched beneficial gut bacteria over one month, without reported diarrhea or flatulence.
Yi W et al. -- Food Sci Nutr
A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARIBS): a randomised controlled trialRandomized controlled trial2024
This head-to-head randomized trial compared a low FODMAP diet, a low-carb diet, and standard medication for treating IBS symptoms.
Nybacka S; Törnblom H; Josefsson A; Hreinsson JP; Böhn L; Frändemark Å; Weznaver C; Störsrud S; Simrén M -- PubMed
Consumption of Solnul Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical TrialRandomized controlled trial2023
A resistant starch supplement increased beneficial Bifidobacterium and Akkermansia levels compared with placebo in this randomized trial.
Jason R Bush; Joshua Baisley; Scott V Harding; Michelle J Alfa -- PubMed Central (PMC)
The Efficacy and Safety of Single-Strain Probiotic Formulations Containing Bifidobacterium lactis or Bacillus coagulans in Adult Patients with Irritable Bowel SyndromeClinical trial2023
A three-arm randomized trial found single-strain probiotics improved IBS symptom scores compared with placebo.
Barbara Skrzydło-Radomańska; Beata Prozorow-Król; Anetta Kurzeja-Mirosław; Halina Cichoż-Lach; Katarzyna Laskowska; Emilia Majsiak; Joanna B Bierła; Sowińska Agnieszka; Bożena Cukrowska -- PubMed Central (PMC)
A single-centre double-blind placebo-controlled randomized study of a digestive health supplementTrial registry2024
Registry confirms the completed trial design and prespecified outcomes; no registry results were posted in the captured record
Pharmanex sponsor; investigator details in registry -- ClinicalTrials.gov NCT06680219
Higher total faecal short-chain fatty acid concentrations correlate with increasing proportions of butyrate and decreasing proportions of branched-chain fatty acids across multiple human studiesCohort study2024
Pooling faecal samples from 163 volunteers across 10 studies, higher total short-chain fatty acid levels were linked to a greater share of butyrate and less protein-fermentation byproduct, tied to lower colonic pH.
LaBouyer M; Holtrop G; Horgan G; Gratz SW; Belenguer A; Smith N; Walker AW; Duncan SH; Johnstone AM; Louis P; Flint HJ; Scott KP -- Gut Microbiome (Cambridge)
Differential Gut Microbiome Profiles in Long-Distance Endurance Cyclists and RunnersCohort study2024
Endurance cyclists and runners showed distinct gut bacterial profiles compared with each other and with non-athletes.
Guy Shalmon; Rawan Ibrahim; Ifat Israel-Elgali; Meitar Grad; Rani Shlayem; Guy Shapira; Noam Shomron; Ilan Youngster; Mickey Scheinowitz -- PubMed Central (PMC)
Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in Caenorhabditis elegansEmergingAnimal study2023
Gut-bacteria-fermented urolithin A extended lifespan and improved markers of mitophagy and oxidative stress in a roundworm model, consistent with urolithin A's proposed cellular-cleanup mechanism.
Zhang M, Cui S, Mao B, Zhang Q, Zhao J, Tang X, Chen W -- Journal of Agricultural and Food Chemistry
Prebiotic xylooligosaccharides ameliorate metabolic dysfunction-associated steatotic liver disease via modulating gut microbiota and metabolitesEmerging2026
In mice on a high-fat diet for 16 weeks, xylooligosaccharides at 1.0 g/kg but not 0.38 g/kg lowered serum ALT and triglycerides and reduced hepatic steatosis.
Li Chen; Ti-Dong Shan
Enzymatic production of prebiotic xylooligosaccharidesEmerging2026
This review summarises prebiotic activities attributed to xylooligosaccharides and their reported effects on the gut microbiome, alongside remaining production challenges.
Lucas Filipe Almeida; Lanyu Li; RRP de Vries; Peicheng Sun; Gabriela Piccolo Maitan‐Alfenas -- World Journal of Microbiology and Biotechnology
XOS-based prebiotic complex improves laying performance and attenuates inflammation-driven gut injury and dysbiosis under LPS challengeEmerging2026
In 600 laying hens fed 0 to 0.4% of a xylooligosaccharide complex for 12 weeks, 0.2% improved egg production and feed conversion, and after an LPS challenge preserved ileal villus height.
Uchechukwu Edna Obianwuna; Peiran Xin; Chengfu Xin; Haijun Zhang; Kai Qiu; Jing Wang; Jianmin Zhou; Shugeng Wu
Impact of Xylooligosaccharides Containing Soluble Lignin Fractions from Birch on Prebiotic Activity by In Vitro Fecal Fermentation of Smoking-Linked Dysbiotic Subhealthy Gut MicrobiotaEmerging2026
Two xylo-oligosaccharide samples affected gut microbiota composition, metabolic function and antioxidant capacity, supporting application in functional food development.
Fang L; Lai C; Chen Y; Huang C; Hua Q; Yong Q
Production of Xylooligosaccharides (XOSs) with Anti-inflammatory and Prebiotic Activities Using Recombinant Endo-1,4-β-xylanases from <i>Bacillus subtilis</i>Emerging2026
Two recombinant Bacillus subtilis xylanases converted xylan into 53% and 51% xylooligosaccharides, over 90% of which were short chains, and the products showed prebiotic and anti-inflammatory activity in human monocytes.
Nguyen Cao Cuong; Dietmar Haltrich; Apichat Boontawan; Montarop Yamabhai
The prebiotic potential of xylooligosaccharides: status, challenges, and future prospectsEmerging2026
This review covers the status of xylooligosaccharide prebiotics, the discovery of new XOS-utilising gut bacteria, and development of XOS-based synbiotics for human nutraceutical use.
Xinge Hu; Farhan Anwar Khan; Tom Tabler; Nicole Labbé; Jun Lin -- Food, Nutrition and Health
Genetic and enzymatic basis of xylooligosaccharide metabolism by <i>Bifidobacterium longum</i>Emerging2026
Strain-level variation in bifidobacterial carbohydrate metabolism of xylooligosaccharides was characterised, informing design of targeted prebiotic and synbiotic strategies.
Friess L; McAuliffe FM; Cotter PD; Munoz-Munoz J; Shiver AL; Huang KC; de Jong A; van Sinderen D
Xylo-oligosaccharide supplementation exacerbates colitis susceptibility in mice via taurine depletionEmerging2026
In C57BL/6J mice, 12 weeks of dietary xylo-oligosaccharide supplementation worsened DSS-induced ulcerative colitis severity, reduced gut microbial diversity and taurine levels, while short-term supplementation during colitis induction did not increase severity.
Li Y; Kong H; Li C; Li D; Gu Z; Li Z -- Food research international (Ottawa, Ont.)
Prebiotic xylo-oligosaccharides for alleviation of hepatic steatosis: results from a four-month dietary intervention and determinants of responseEmerging2026
In a 42-adult open-label trial without a separate control group, four months of daily xylo-oligosaccharide supplement lowered visceral and liver fat alongside gut metabolite changes in people with early hepatic steatosis, though non-responders had more advanced disease.
Jukka Hintikka; Perttu Permi; Marko Lehtonen; Sanna Lensu; Anastasiia Driuchina; Mika Jormanainen; Jari A. Laukkanen; Nitin Bayal; Pande Putu Erawijantari; Thomas M. O’Connell; Leo Lahti; Satu Pekkala -- npj Gut and Liver
Balanced by design -- we show supporting and contradicting findings. Search all studies
If you have had labs done
These are lab markers where this product's ingredients have measured evidence in our citation library. This is not a claim that the product will change your results -- the research attaches to the ingredient, and what a marker means depends on the whole picture. Each one links to its full entry, including what typically moves it and how to read it.
- Fecal Short-Chain Fatty Acids (SCFAs)emerging evidence
via Xylooligosaccharides (XOS) · 18 studies, 2 in people
What people often notice when this marker sits outside the usual range
Higher: Very high fecal SCFAs may reflect malabsorption or rapid transit rather than a thriving microbiome.
Lower: Constipation or sluggish transit.
- Fecal Calprotectinemerging evidence
via Pomegranate extract · 1 studies, 1 in people
A 12-week juice intervention with a modulatory effect on the relevant transcriptional profile.
What people often notice when this marker sits outside the usual range
Higher: Diarrhoea, often with urgency; blood or mucus in stool.
Lab results are interpreted by a qualified clinician who knows your history. Nothing here diagnoses anything or replaces that conversation.
No product works in isolation
Every cell function above -- Sense, Exchange, Transform, Build, Maintain, Adapt -- needs the same broad base of optimal micronutrient levels running underneath it, all the time. Nu Biome is not a stand-alone fix; it is one piece that plugs into that larger system. The foundation comes first, and this supports it.
Stacks well with
Pick your goal -- here is what Nu Biome pairs with for each. Nothing works in isolation; these share the same systems.
For Gut Health
For Women's Health
For Mood & Hormones
For Immune
Foundational, or targeted?
Not everything in the shop is meant to be taken forever. Some products here are foundational -- a daily nutrient base built for long-term, ongoing use. Others are targeted -- shorter-term support for a specific season, not a lifelong habit. If you are not sure which one this is, that is a fair question to ask us before you buy.
Learn more, on your terms
Do not take our word for it -- go read. Each topic below opens a pre-loaded search so you can explore the nutrient, the mechanism, or the device for yourself.
Search the full studies libraryHow to use it
Mix one stick into water once daily and drink. It contains about 50 mg of caffeine, so earlier in the day suits most people better than the evening.
Where to get it
Ready when you are. This link takes you to the official, verified source for this product.
Get Nu BiomeThe studies
See the research behind the science we point to.
Explore studiesThe blog
Plain-language reads on how it all fits together.
Read the blogOptimal nutrients are the definition of longevity
Long-term cell function depends on having what it needs, at the level it needs it, for as long as it needs it. That is the whole thesis behind everything we point you to here.
When you buy through our links, we earn a small commission -- and that is what funds all the free education here. It never costs you more. Products are not intended to diagnose, treat, cure, or prevent any disease.
Nu Biome is a once-daily drink stick with xylooligosaccharides (a prebiotic fiber), a heat-treated postbiotic form of Bifidobacterium animalis BPL1, and pomegranate, plus a small amount of caffeine. It is aimed at supporting a healthy gut environment. It fits anyone who wants sensible daily gut support.
FAQ
What does Nu Biome support?
It supports a healthy gut environment, provides prebiotic fiber that feeds beneficial gut bacteria, supports a healthy inflammation response already within normal range, and complements a fiber-rich, whole-food diet.
How do I take it?
Mix one stick into water once daily and drink. It contains a small amount of caffeine, so earlier in the day suits most people better than the evening.
What makes it different?
It feeds the gut with both a prebiotic fiber and a studied postbiotic. The exact amounts in the blend are not fully disclosed, so it is framed as sensible daily gut support, not a fix for anything.